(Q79967745)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17366662%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

title

Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen-induced liver injury (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17366662%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

1 reference

ChEBI release 2020-05-28

ChEBI ID

6402

author name string

Calivarathan Latchoumycandane

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17366662%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

Catherine W Goh

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17366662%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

Michie M K Ong

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17366662%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

Urs A Boelsterli

4

1 reference

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27 December 2019

language of work or name

English

0 references

publication date

1 February 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17366662%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17366662%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

volume

45

1 reference

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27 December 2019

issue

2

1 reference

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27 December 2019

page(s)

412-421

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17366662%20AND%20SRC:MED&resulttype=core&format=json

Drug-induced hepatotoxicity.

27 December 2019

cites work

1 reference

7 January 2021

Acetaminophen-induced hepatotoxicity

1 reference

7 January 2021

Intracellular signaling mechanisms of acetaminophen-induced liver cell death

1 reference

7 January 2021

Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes

1 reference

7 January 2021

Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice

1 reference

7 January 2021

Mode of cell death after acetaminophen overdose in mice: apoptosis or oncotic necrosis?

1 reference

7 January 2021

c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity

1 reference

7 January 2021

Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes: protection by N-acetyl cysteine

1 reference

7 January 2021

Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)

1 reference

7 January 2021

Leflunomide or A77 1726 protect from acetaminophen-induced cell injury through inhibition of JNK-mediated mitochondrial permeability transition in immortalized human hepatocytes

1 reference

7 January 2021

Leflunomide protects from T-cell-mediated liver injury in mice through inhibition of nuclear factor kappaB.

1 reference

7 January 2021

Effect of leflunomide on immunological liver injury in mice

1 reference

7 January 2021

Nimesulide-induced hepatic mitochondrial injury in heterozygous Sod2(+/-) mice

1 reference

7 January 2021

Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity

1 reference

7 January 2021

Role of substance P and the neurokinin 1 receptor in acute pancreatitis and pancreatitis-associated lung injury.

1 reference

7 January 2021

Genomic identification of potential risk factors during acetaminophen-induced liver disease in susceptible and resistant strains of mice

1 reference

7 January 2021

Acetaminophen hepatotoxicity in tumor necrosis factor/lymphotoxin-alpha gene knockout mice

1 reference

7 January 2021

The nitric oxide donor, V-PYRRO/NO, protects against acetaminophen-induced hepatotoxicity in mice

1 reference

7 January 2021

The anti-inflammatory drug, nimesulide (4-nitro-2-phenoxymethane-sulfoanilide), uncouples mitochondria and induces mitochondrial permeability transition in human hepatoma cells: protection by albumin

1 reference

7 January 2021

Role of nitric oxide in acetaminophen-induced hepatotoxicity in the rat

1 reference

7 January 2021

Nitrotyrosine-protein adducts in hepatic centrilobular areas following toxic doses of acetaminophen in mice.

1 reference

7 January 2021

Vascular and hepatocellular peroxynitrite formation during acetaminophen toxicity: role of mitochondrial oxidant stress

1 reference

7 January 2021

Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity

1 reference

7 January 2021

Aurothiomalate and hydroxychloroquine inhibit nitric oxide production in chondrocytes and in human osteoarthritic cartilage

1 reference

7 January 2021

Checkpoints of dueling dimers foil death wishes

1 reference

7 January 2021

BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.

1 reference

7 January 2021

An active metabolite of leflunomide, A77 1726, inhibits the production of serum amyloid A protein in human hepatocytes

1 reference

7 January 2021

Suppressive effect of leflunomide metabolite (A77 1726) on metalloproteinase production in IL-1beta stimulated rheumatoid synovial fibroblasts

1 reference

7 January 2021

Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes

1 reference

7 January 2021

JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species

1 reference

7 January 2021

Oxidant-induced hepatocyte injury from menadione is regulated by ERK and AP-1 signaling

1 reference

7 January 2021

Reactive oxygen species mediate crosstalk between NF-kappaB and JNK.

1 reference

7 January 2021

Novel role for JNK as a stress-activated Bcl2 kinase

1 reference

7 January 2021

JNK- and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells

1 reference

7 January 2021

Reduced hepatotoxicity of acetaminophen in mice lacking inducible nitric oxide synthase: potential role of tumor necrosis factor-alpha and interleukin-10.

1 reference

7 January 2021

Protection against acetaminophen-induced liver injury and lethality by interleukin 10: role of inducible nitric oxide synthase

1 reference

7 January 2021

Effect of a potent iNOS inhibitor (ONO-1714) on acetaminophen-induced hepatotoxicity in the rat.

1 reference

7 January 2021

IFN-gamma + LPS induction of iNOS is modulated by ERK, JNK/SAPK, and p38(mapk) in a mouse macrophage cell line

1 reference

7 January 2021

Inhibition of p38 mitogen-activated protein kinase enhances c-Jun N-terminal kinase activity: implication in inducible nitric oxide synthase expression

1 reference

7 January 2021

Evidence for peroxynitrite as a signaling molecule in flow-dependent activation of c-Jun NH(2)-terminal kinase

1 reference

7 January 2021

Detoxification of reactive oxygen species by a nonpeptidyl mimic of superoxide dismutase cures acetaminophen-induced acute liver failure in the mouse

1 reference

7 January 2021

Identifiers

DOI

10.1002/HEP.21475

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17366662%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

1 reference