(Q36263962)

13 August 2017

1 reference

title

Intracellular signaling mechanisms of acetaminophen-induced liver cell death (English)

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13 August 2017

1 reference

Hartmut Jaeschke

1

1 reference

PubMed ID

16177235

13 August 2017

Mary Lynn Bajt

series ordinal

2

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13 August 2017

21 September 2005

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13 August 2017

Toxicological Sciences

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13 August 2017

89

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13 August 2017

31-41

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13 August 2017

1

1 reference

Scavenging peroxynitrite with glutathione promotes regeneration and enhances survival during acetaminophen-induced liver injury in mice

13 August 2017

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes: protection by N-acetyl cysteine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Acetaminophen induces a caspase-dependent and Bcl-XL sensitive apoptosis in human hepatoma cells and lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Protection against acetaminophen-induced liver injury and lethality by interleukin 10: role of inducible nitric oxide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

BCL-2 family: regulators of cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Hepatobiliary excretion of acetaminophen glutathione conjugate and its derivatives in transport-deficient (TR-) hyperbilirubinemic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Selective protein covalent binding and target organ toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Role of tumor necrosis factor receptor 1 (p55) in hepatocyte proliferation during acetaminophen-induced toxicity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Immediate rise in intracellular calcium and glycogen phosphorylase a activities upon acetaminophen covalent binding leading to hepatotoxicity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Pathophysiological role of poly(ADP-ribose) polymerase (PARP) activation during acetaminophen-induced liver cell necrosis in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Peroxynitrite and drug-dependent toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Involvement of mitochondria in acetaminophen-induced apoptosis and hepatic injury: roles of cytochrome c, Bax, Bid, and caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Detoxification of reactive oxygen species by a nonpeptidyl mimic of superoxide dismutase cures acetaminophen-induced acute liver failure in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Knockout of cellular glutathione peroxidase gene renders mice susceptible to diquat-induced oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Reduced hepatotoxicity of acetaminophen in mice lacking inducible nitric oxide synthase: potential role of tumor necrosis factor-alpha and interleukin-10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

NADPH oxidase-derived oxidant stress is critical for neutrophil cytotoxicity during endotoxemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Mode of cell death after acetaminophen overdose in mice: apoptosis or oncotic necrosis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Inhibition of carbamyl phosphate synthetase-I and glutamine synthetase by hepatotoxic doses of acetaminophen in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Oxidative stress in cell culture: an under-appreciated problem?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Regulated and unregulated mitochondrial permeability transition pores: a new paradigm of pore structure and function?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Portrait of a killer: the mitochondrial apoptosome emerges from the shadows

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Effect of inhibitors of nitric oxide synthase on acetaminophen-induced hepatotoxicity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Nitrotyrosine-protein adducts in hepatic centrilobular areas following toxic doses of acetaminophen in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Mitochondrial permeability transition as a novel principle of hepatorenal toxicity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Role of inflammation in the mechanism of acetaminophen-induced hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Protection against TNF-induced liver parenchymal cell apoptosis during endotoxemia by a novel caspase inhibitor in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Mechanisms of hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Apoptosis and necrosis in liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Interleukin 6 and hepatocyte regeneration in acetaminophen toxicity in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Acetaminophen toxicity in mice lacking NADPH oxidase activity: role of peroxynitrite formation and mitochondrial oxidant stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Effect of N-acetylcysteine on acetaminophen toxicity in mice: relationship to reactive nitrogen and cytokine formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Effect of a potent iNOS inhibitor (ONO-1714) on acetaminophen-induced hepatotoxicity in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Mitochondrial permeability transition: a common pathway to necrosis and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Inhibition of peroxynitrite-induced nitration of tyrosine by glutathione in the presence of carbon dioxide through both radical repair and peroxynitrate formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Role of lipid peroxidation as a mechanism of liver injury after acetaminophen overdose in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Peroxynitrite is a critical mediator of acetaminophen hepatotoxicity in murine livers: protection by glutathione

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Acetaminophen-induced inhibition of Fas receptor-mediated liver cell apoptosis: mitochondrial dysfunction versus glutathione depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Vascular and hepatocellular peroxynitrite formation during acetaminophen toxicity: role of mitochondrial oxidant stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Calpain released from dying hepatocytes mediates progression of acute liver injury induced by model hepatotoxicants

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

The role of calpain in oncotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Glycogen synthase kinase-3 mediates acetaminophen-induced apoptosis in human hepatoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Tissue repair: an important determinant of final outcome of toxicant-induced injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Poly(ADP-ribose) polymerases: managing genome stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Acetaminophen-induced hepatotoxicity in mice lacking inducible nitric oxide synthase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-alpha-induced apoptosis in cultured mouse hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Degradation of chromosomal DNA during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Molecular mechanisms of the hepatotoxicity caused by acetaminophen

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

AASLD position paper: the management of acute liver failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

In vitro effects of acetaminophen metabolites and analogs on the respiration of mouse liver mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Mechanisms of acetaminophen-induced hepatotoxicity: role of oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Expression profiling of acetaminophen liver toxicity in mice using microarray technology

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Genomics and proteomics analysis of acetaminophen toxicity in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Acetaminophen misconceptions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Mechanisms of cytochrome c release by proapoptotic BCL-2 family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Acetaminophen-induced cytotoxicity in cultured mouse hepatocytes: correlation of nuclear Ca2+ accumulation and early DNA fragmentation with cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

The shark bile salt 5 beta-scymnol abates acetaminophen toxicity, but not covalent binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Two distinct pathways leading to nuclear apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Subliminal Fas stimulation increases the hepatotoxicity of acetaminophen and bromobenzene in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Alkylation of the liver plasma membrane and inhibition of the Ca2+ ATPase by acetaminophen

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Endonuclease G: a mitochondrial protein released in apoptosis and involved in caspase-independent DNA degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Proteomic identification of potential susceptibility factors in drug-induced liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

A role of the Ca2+/Mg2+-dependent endonuclease in apoptosis and its inhibition by Poly(ADP-ribose) polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Role of DNAS1L3 in Ca2+- and Mg2+-dependent cleavage of DNA into oligonucleosomal and high molecular mass fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Multiple mechanisms are involved in the biliary excretion of acetaminophen sulfate in the rat: role of Mrp2 and Bcrp1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFI336

21 January 2018

Identifiers

DOI

10.1093/TOXSCI/KFI336

1 reference

13 August 2017

1 reference

PubMed ID

16177235