(Q80543447)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17599073%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

title

Mechanisms of disease: role of chondrocytes in the pathogenesis of osteoarthritis--structure, chaos and senescence (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17599073%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

1 reference

4

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1 January 2020

author name string

Thomas Aigner

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17599073%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Stefan Söder

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17599073%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Pia M Gebhard

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17599073%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Jochen Haag

5

1 reference

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1 January 2020

publication date

1 July 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17599073%20AND%20SRC:MED&resulttype=core&format=json

Nature Clinical Practice Rheumatology

1 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17599073%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

volume

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17599073%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17599073%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

page(s)

391-399

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17599073%20AND%20SRC:MED&resulttype=core&format=json

Aging theories of primary osteoarthritis: from epidemiology to molecular biology.

1 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Insulin-like growth factor (IGF) receptor, IGF-I, interleukin-1 beta (IL-1 beta), and IL-6 mRNA expression in osteoarthritic and normal human cartilage

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Upregulation of insulin-like growth factor I gene expression in the lesions of osteoarthritic human articular cartilage

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Relative messenger RNA expression profiling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

The effects of isolation on chondrocyte gene expression.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Cartilage damaging activities of fibronectin fragments derived from cartilage and synovial fluid

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

A fibronectin fragment induces type II collagen degradation by collagenase through an interleukin-1-mediated pathway

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

The role of collagenolytic matrix metalloproteinases in the loss of articular cartilage in osteoarthritis

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

A contentious issue finds some clarity: on the independent and complementary roles of aggrecanase activity and MMP activity in human joint aggrecanolysis.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

ADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulfate-rich region of aggrecan.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Suppression of cartilage matrix gene expression in upper zone chondrocytes of osteoarthritic cartilage

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Growth plate cartilage as developmental model in osteoarthritis research--potentials and limitations

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Reexpression of type IIA procollagen by adult articular chondrocytes in osteoarthritic cartilage

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Severe disturbance of the distribution and expression of type VI collagen chains in osteoarthritic articular cartilage

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Tenascin is increased in cartilage and synovium from arthritic knees

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Quantification of expression levels of cellular differentiation markers does not support a general shift in the cellular phenotype of osteoarthritic chondrocytes

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Collagen type I antisense and collagen type IIA messenger RNA is expressed in adult murine articular cartilage

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Immunolocalization of type X collagen in normal fetal and adult osteoarthritic cartilage with monoclonal antibodies

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

IL-8/CXCL8 and growth-related oncogene alpha/CXCL1 induce chondrocyte hypertrophic differentiation

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Bone morphogenetic protein-mediating receptor-associated Smads as well as common Smad are expressed in human articular chondrocytes but not up-regulated or down-regulated in osteoarthritic cartilage

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Bone morphogenetic protein and transforming growth factor beta inhibitory Smads 6 and 7 are expressed in human adult normal and osteoarthritic cartilage in vivo and are differentially regulated in vitro by interleukin-1beta.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Mitosis in Human Osteoarthritic Cartilage

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Apoptotic cell death is not a widespread phenomenon in normal aging and osteoarthritis human articular knee cartilage: a study of proliferation, programmed cell death (apoptosis), and viability of chondrocytes in normal and osteoarthritic human knee

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Osteoarthritis chondrocytes die by apoptosis: A possible pathway for osteoarthritis pathology

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Human chondrocyte apoptosis in response to mechanical injury

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Caspase inhibitors reduce severity of cartilage lesions in experimental osteoarthritis

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Reduction in the chondrocyte response to insulin-like growth factor 1 in aging and osteoarthritis: studies in a non-human primate model of naturally occurring disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Freshly isolated osteoarthritic chondrocytes are catabolically more active than normal chondrocytes, but less responsive to catabolic stimulation with interleukin-1beta

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Catabolic stress induces features of chondrocyte senescence through overexpression of caveolin 1: possible involvement of caveolin 1-induced down-regulation of articular chondrocytes in the pathogenesis of osteoarthritis.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Accumulation of advanced glycation end products as a molecular mechanism for aging as a risk factor in osteoarthritis

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Activation of receptor for advanced glycation end products in osteoarthritis leads to increased stimulation of chondrocytes and synoviocytes

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Effects of oxidative damage and telomerase activity on human articular cartilage chondrocyte senescence

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Chondroptosis: a variant of apoptotic cell death in chondrocytes?

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Down-regulation of the GTPase RhoB might be involved in the pre-apoptotic phenotype of osteoarthritic chondrocytes

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Anabolic and catabolic gene expression pattern analysis in normal versus osteoarthritic cartilage using complementary DNA-array technology

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Rho GTPases and the actin cytoskeleton

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

RhoB is required to mediate apoptosis in neoplastically transformed cells after DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Actin' up: RhoB in cancer and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

New thoughts on the pathophysiology of osteoarthritis: one more step toward new therapeutic targets

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Most recent developments in strategies to reduce the progression of structural changes in osteoarthritis: today and tomorrow

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Prospects for disease modification in osteoarthritis.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0534

7 January 2021

Identifiers

DOI

10.1038/NCPRHEUM0534

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17599073%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

1 reference