(Q80725712)

English

The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection

scientific article published on 01 August 2007

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17670976%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17670976%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

neurodegeneration

1 reference

based on heuristic

inferred from title

Giuseppe Battaglia

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17670976%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Ferdinando Nicoletti

8

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17670976%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Valeria Maria Gloria Bruno

9

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17670976%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

author name string

Corrado Corti

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17670976%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Gemma Molinaro

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17670976%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Barbara Riozzi

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17670976%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Anna Pittaluga

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17670976%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Mauro Corsi

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17670976%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Manolo Mugnaini

7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17670976%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

publication date

1 August 2007

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17670976%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17670976%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

27

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17670976%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

31

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17670976%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

8297-8308

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17670976%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Neuroprotection by metabotropic glutamate receptor glutamate receptor agonists: LY354740, LY379268 and LY389795.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of A(1) adenosine or mGlu3 metabotropic glutamate receptors enhances the release of nerve growth factor and S-100beta protein from cultured astrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LY379268, a potent and selective Group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal, cerebral ischaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological agents acting at subtypes of metabotropic glutamate receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective activation of group II mGluRs with LY354740 does not prevent neuronal excitotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Transforming Growth Factor-β Antagonist Unmasks the Neuroprotective Role of This Endogenous Cytokine in Excitotoxic and Ischemic Brain Injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective actions of novel and potent ligands of group I and group II metabotropic glutamate receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective activation of mGlu4 metabotropic glutamate receptors is protective against excitotoxic neuronal death

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective blockade of metabotropic glutamate receptor subtype 5 is neuroprotective

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Group II metabotropic glutamate receptor activation protects striatal dopaminergic nerve terminals against MPP+-induced neurotoxicity along with brain-derived neurotrophic factor induction

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design of NAALADase inhibitors: a novel neuroprotective strategy

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective blockade of type-1 metabotropic glutamate receptors induces neuroprotection by enhancing gabaergic transmission

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotection mediated by glial group-II metabotropic glutamate receptors requires the activation of the MAP kinase and the phosphatidylinositol-3-kinase pathways.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabotropic glutamate receptor subtypes as targets for neuroprotective drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upregulation of [3H]methyllycaconitine binding sites following continuous infusion of nicotine, without changes of alpha7 or alpha6 subunit mRNA: an autoradiography and in situ hybridization study in rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective role of group-II metabotropic glutamate receptors against nigro-striatal degeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-acetylaspartylglutamate acts as an agonist upon homomeric NMDA receptor (NMDAR1) expressed in Xenopus oocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-acetylaspartylglutamate and β-NAAG protect against injury induced by NMDA and hypoxia in primary spinal cord cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein measurement with the Folin phenol reagent

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NAAG fails to antagonize synaptic and extrasynaptic NMDA receptors in cerebellar granule neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Risk factors for dopaminergic neuron loss in human alpha-synuclein transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological manipulation of mGlu2 receptors influences cognitive performance in the rodent

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NAAG reduces NMDA receptor current in CA1 hippocampal pyramidal neurons of acute slices and dissociated neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anxiolytic-like activity of the mGLU2/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) decreases synaptic excitation in rat striatal slices through a presynaptic action

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of mGlu2 or mGlu3 receptor deletions on mGlu2/3 receptor agonist (LY354740)-induced brain c-Fos expression: specific roles for mGlu2 in the amygdala and subcortical nuclei, and mGlu3 in the hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection of substantia nigra from MPP+ neurotoxicity by N-methyl-D-aspartate antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted replacement of the homeobox gene Hox-3.1 by the Escherichia coli lacZ in mouse chimeric embryos

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Permeation and block of N-methyl-D-aspartic acid receptor channels by divalent cations in mouse cultured central neurones

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A rapid method for isolation of synaptosomes on Percoll gradients

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High concentrations of N-acetylaspartylglutamate (NAAG) selectively activate NMDA receptors on mouse spinal cord neurons in cell culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabotropic glutamate receptor-mediated presynaptic depression at corticostriatal synapses involves mGLuR2 or 3

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The metabotropic glutamate receptors: structure and functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-acetylaspartylglutamate inhibits forskolin-stimulated cyclic AMP levels via a metabotropic glutamate receptor in cultured cerebellar granule cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transforming growth factor-beta protects human neurons against beta-amyloid-induced injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabotropic glutamate receptors negatively coupled to adenylate cyclase inhibit N-methyl-D-aspartate receptor activity and prevent neurotoxicity in mesencephalic neurons in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of metabotropic glutamate receptors protects cultured neurons against apoptosis induced by beta-amyloid peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of metabotropic glutamate receptors prevents neuronal apoptosis in culture.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of neuronal Bcl2 protein expression and calcium homeostasis by transforming growth factor type beta confers wide-ranging protection on rat hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Attenuation of excitatory amino acid toxicity by metabotropic glutamate receptor agonists and aniracetam in primary cultures of cerebellar granule cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of class II or III metabotropic glutamate receptors protects cultured cortical neurons against excitotoxic degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The inhibitory mGluR agonist, S-4-carboxy-3-hydroxy-phenylglycine selectively attenuates NMDA neurotoxicity and oxygen-glucose deprivation-induced neuronal death

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effect of transforming growth factor-beta 1 on beta-amyloid neurotoxicity in rat hippocampal neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a potent and selective antagonist of type 2 metabotropic glutamate receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

gp120-induced neurotoxicity in hippocampal pyramidal neuron cultures: protective action of TGF-beta1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Opposite effects of TGF-beta 1 on rapidly- and slowly-triggered excitotoxic injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TGF-beta 1 protects hippocampal neurons against degeneration caused by transient global ischemia. Dose-response relationship and potential neuroprotective mechanisms.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neuroprotective activity of group-II metabotropic glutamate receptors requires new protein synthesis and involves a glial-neuronal signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Positive and negative coupling of the metabotropic glutamate receptors to a G protein-activated K+ channel, GIRK, in Xenopus oocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo inhibition of veratridine-evoked release of striatal excitatory amino acids by the group II metabotropic glutamate receptor agonist LY354740 in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Type 2 metabotropic glutamate (mGlu) receptors tonically inhibit transmitter release in rat caudate nucleus: in vivo studies with (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a new potent and selective antagonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TGF-beta1 prevents gp120-induced impairment of Ca2+ homeostasis and rescues cortical neurons from apoptotic death

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transforming growth factor-beta protects human hNT cells from degeneration induced by beta-amyloid peptide: involvement of the TGF-beta type II receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-acetylaspartylglutamate (NAAG) protects against rat striatal quinolinic acid lesions in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transforming growth factor-betas in neurodegenerative disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of MPTP toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective activity of N-acetylaspartylglutamate in cultured cortical cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The metabotropic glutamate receptor mGlu5 controls the onset of developmental apoptosis in cultured cerebellar neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective activation of group-II metabotropic glutamate receptors is protective against excitotoxic neuronal death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotection by glial metabotropic glutamate receptors is mediated by transforming growth factor-beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/17670976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.1889-07.2007

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17670976%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17670976%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17670976%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q80725712&oldid=2165702778"