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IL-12 up-regulates T-bet independently of IFN-gamma in human CD4+ T cells
scientific article published on 01 November 2005
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1 reference
stated in
Europe PubMed Central
PubMed publication ID
16220539
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16220539%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 January 2020
title
IL-12 up-regulates T-bet independently of IFN-gamma in human CD4+ T cells
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
16220539
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16220539%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 January 2020
author
Riikka Lund
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
16220539
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16220539%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 January 2020
Minna K Kyläniemi
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3
1 reference
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Europe PubMed Central
PubMed publication ID
16220539
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16220539%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 January 2020
Riitta Lahesmaa
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7
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Riitta Lahesmaa
1 reference
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Europe PubMed Central
PubMed publication ID
16220539
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16220539%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 January 2020
Emmi K Ylikoski
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1
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Emmi Ylikoski
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Europe PubMed Central
PubMed publication ID
16220539
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16220539%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 January 2020
author name string
Sanna Filén
series ordinal
4
1 reference
stated in
Europe PubMed Central
PubMed publication ID
16220539
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16220539%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 January 2020
Maritta Kilpeläinen
series ordinal
5
1 reference
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Europe PubMed Central
PubMed publication ID
16220539
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16220539%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 January 2020
Johannes Savolainen
series ordinal
6
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Europe PubMed Central
PubMed publication ID
16220539
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16220539%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 January 2020
publication date
1 November 2005
1 reference
stated in
Europe PubMed Central
PubMed publication ID
16220539
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16220539%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 January 2020
published in
European Journal of Immunology
1 reference
stated in
Europe PubMed Central
PubMed publication ID
16220539
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16220539%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 January 2020
volume
35
1 reference
stated in
Europe PubMed Central
PubMed publication ID
16220539
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16220539%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 January 2020
issue
11
1 reference
stated in
Europe PubMed Central
PubMed publication ID
16220539
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16220539%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 January 2020
page(s)
3297-3306
1 reference
stated in
Europe PubMed Central
PubMed publication ID
16220539
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16220539%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 January 2020
cites work
An interleukin-4-induced transcription factor: IL-4 Stat
1 reference
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Crossref
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7 January 2021
based on heuristic
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Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages
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7 January 2021
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Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4
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Crossref
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7 January 2021
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Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
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https://api.crossref.org/works/10.1002%2FEJI.200526101
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7 January 2021
based on heuristic
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Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.
1 reference
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reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
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7 January 2021
based on heuristic
inferred from DOI database lookup
Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
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7 January 2021
based on heuristic
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Essential role of Stat6 in IL-4 signalling
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
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7 January 2021
based on heuristic
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Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
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Crossref
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https://api.crossref.org/works/10.1002%2FEJI.200526101
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7 January 2021
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Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
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7 January 2021
based on heuristic
inferred from DOI database lookup
Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
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7 January 2021
based on heuristic
inferred from DOI database lookup
Role of T-bet in commitment of TH1 cells before IL-12-dependent selection.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
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7 January 2021
based on heuristic
inferred from DOI database lookup
A novel transcription factor, T-bet, directs Th1 lineage commitment
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Peroxisome proliferator-activated receptor alpha negatively regulates T-bet transcription through suppression of p38 mitogen-activated protein kinase activation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
retrieved
7 January 2021
based on heuristic
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IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cutting Edge: Role of IL-27/WSX-1 Signaling for Induction of T-Bet Through Activation of STAT1 During Initial Th1 Commitment
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
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7 January 2021
based on heuristic
inferred from DOI database lookup
IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
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7 January 2021
based on heuristic
inferred from DOI database lookup
IL-27 and IFN-αSignal via Stat1 and Stat3 and Induce T-Bet and IL-12Rβ2 in Naive T Cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
GATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL-12Rbeta2 chain or T-bet
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sustained T-bet expression confers polarized human TH2 cells with TH1-like cytokine production and migratory capacities☆
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sustained IL-12 signaling is required for Th1 development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transforming growth factor-beta in T-cell biology
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cutting edge: TGF-beta inhibits Th type 2 development through inhibition of GATA-3 expression.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TGF-β1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Kinetics of GATA-3 gene expression in early polarizing and committed human T cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Developmental commitment to the Th2 lineage by extinction of IL-12 signaling.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of novel genes regulated by IL-12, IL-4, or TGF-beta during the early polarization of CD4+ lymphocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Silencing T-bet defines a critical role in the differentiation of autoreactive T lymphocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Early target genes of IL-12 and STAT4 signaling in th cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interferon alpha increases the frequency of interferon gamma-producing human CD4+ T cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differentiation and stability of T helper 1 and 2 cells derived from naive human neonatal CD4+ T cells, analyzed at the single-cell level
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Signaling lymphocytic activation molecule (SLAM) is differentially expressed in human Th1 and Th2 cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification and validation of endogenous reference genes for expression profiling of T helper cell differentiation by quantitative real-time RT-PCR
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.200526101
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1002/EJI.200526101
1 reference
stated in
Europe PubMed Central
PubMed publication ID
16220539
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16220539%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 January 2020
PubMed publication ID
16220539
1 reference
stated in
Europe PubMed Central
PubMed publication ID
16220539
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16220539%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 January 2020
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