(Q81398981)

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Transcriptional responses to ionizing radiation reveal that p53R2 protects against radiation-induced mutagenesis in human lymphoblastoid cells

scientific article published on 01 January 2006

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scholarly article

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Europe PubMed Central

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8 January 2020

Transcriptional responses to ionizing radiation reveal that p53R2 protects against radiation-induced mutagenesis in human lymphoblastoid cells (English)

1 reference

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8 January 2020

1

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8 January 2020

author name string

Chen X

2

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8 January 2020

Chandramouli GV

3

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8 January 2020

Chen Y

4

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8 January 2020

Yan H

5

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8 January 2020

Zhao S

6

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8 January 2020

Keng P

7

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8 January 2020

Liber HL

8

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8 January 2020

Coleman CN

9

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8 January 2020

Mitchell JB

10

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8 January 2020

Chuang EY

11

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8 January 2020

publication date

1 January 2006

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8 January 2020

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8 January 2020

25

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8 January 2020

622-632

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8 January 2020

4

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8 January 2020

https://scigraph.springernature.com/pub.10.1038/sj.onc.1209082

0 references

Identification of potential mRNA biomarkers in peripheral blood lymphocytes for human exposure to ionizing radiation.

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Involvement of TP53 in apoptosis induced in human lymphoblastoid cells by fast neutrons.

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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Repair of double-strand breaks by homologous recombination in mismatch repair-defective mammalian cells

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The Saccharomyces cerevisiae Msh2 mismatch repair protein localizes to recombination intermediates in vivo.

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The DDB2 nucleotide excision repair gene product p48 enhances global genomic repair in p53 deficient human fibroblasts

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Quantitative assay for mutation in diploid human lymphoblasts using microtiter plates

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Unlike tenascin-X, tenascin-C is highly up-regulated in pig cutaneous and underlying muscle tissue developing fibrosis after necrosis induced by very high-dose gamma radiation

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Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells

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Impaired function of p53R2 in Rrm2b-null mice causes severe renal failure through attenuation of dNTP pools

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Regulation of p53 in response to DNA damage

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Stable suppression of the R2 subunit of ribonucleotide reductase by R2-targeted short interference RNA sensitizes p53(-/-) HCT-116 colon cancer cells to DNA-damaging agents and ribonucleotide reductase inhibitors

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Absence of radiation-induced G1 arrest in two closely related human lymphoblast cell lines that differ in p53 status

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p53 sends nucleotides to repair DNA.

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A ribonucleotide reductase gene is a transcriptional target of p53 and p73

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Enhancement of radiosensitivity by proteasome inhibition: implications for a role of NF-kappaB.

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Quantitative monitoring of gene expression patterns with a complementary DNA microarray

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Isolation of a human lymphoblastoid line heterozygous at the thymidine kinase locus: Possibility for a rapid human cell mutation assay

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DNA adducts and chronic degenerative disease. Pathogenetic relevance and implications in preventive medicine.

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A multistep damage recognition mechanism for global genomic nucleotide excision repair

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p53 Binds and activates the xeroderma pigmentosum DDB2 gene in humans but not mice.

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A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

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Induction of p53 and Bax during TGF-beta 1 initiated apoptosis in rat liver epithelial cells

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CREB-binding protein is a nuclear integrator of nuclear factor-kappaB and p53 signaling

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TGF-beta signaling: positive and negative effects on tumorigenesis

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NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

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Transcriptional cross talk between NF-kappaB and p53.

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Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT

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Coordinate modulation of Sp1, NF-kappa B, and p53 in confluent human malignant melanoma cells after ionizing radiation.

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The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase

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Abrogation of p53 function by HPV16 E6 gene delays apoptosis and enhances mutagenesis but does not alter radiosensitivity in TK6 human lymphoblast cells

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