(Q82205802)

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Drug induced shortening of the QT/QTc interval: an emerging safety issue warranting further modelling and evaluation in drug research and development?

scientific article published on 17 September 2008

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scholarly article

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15 January 2020

Drug induced shortening of the QT/QTc interval: an emerging safety issue warranting further modelling and evaluation in drug research and development? (English)

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15 January 2020

author name string

Mark Holbrook

1

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15 January 2020

Marek Malik

2

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15 January 2020

Rashmi R Shah

3

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15 January 2020

Jean-Pierre Valentin

4

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publication date

17 September 2008

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15 January 2020

Journal of Pharmacological and Toxicological Methods

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15 January 2020

59

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15 January 2020

21-28

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15 January 2020

1

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15 January 2020

QT interval prolongation in acute myocardial infarction

1 reference

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Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death

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Mutation in the KCNQ1 gene leading to the short QT-interval syndrome.

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A common polymorphism in KCNH2 (HERG) hastens cardiac repolarization

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Short QT syndrome: mechanisms, diagnosis and treatment

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Long and short QT syndrome

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Short QT syndrome. Genotype-phenotype correlations

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Sudden death associated with short-QT syndrome linked to mutations in HERG.

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The short QT syndrome as a paradigm to understand the role of potassium channels in ventricular fibrillation

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Quinidine-induced action potential prolongation, early afterdepolarizations, and triggered activity in canine Purkinje fibers. Effects of stimulation rate, potassium, and magnesium

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Amplified transmural dispersion of repolarization as the basis for arrhythmogenesis in a canine ventricular-wedge model of short-QT syndrome

1 reference

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7 January 2021

Electrocardiographic biomarkers of ventricular repolarisation in a single family of short QT syndrome and the role of the Bazett correction formula.

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7 January 2021

Drug-induced torsades de pointes and implications for drug development.

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7 January 2021

Short QT syndrome: pharmacological treatment

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7 January 2021

Is acquired short QT due to digitalis intoxication responsible for malignant ventricular arrhythmias?

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7 January 2021

Digoxin in the management of cardiovascular disorders

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7 January 2021

Short QT syndrome: clinical findings and diagnostic-therapeutic implications

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7 January 2021

Idiopathic short QT interval: a new clinical syndrome?

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7 January 2021

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7 January 2021

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Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643).

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Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623 [N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N'-(3'-trifluoromethylphenyl)urea].

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Inducibility of life-threatening ventricular arrhythmias is related to maximum left ventricular thickness and clinical markers of sudden cardiac death in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha-t

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Amiodarone-associated proarrhythmic effects. A review with special reference to torsade de pointes tachycardia

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Relative contributions of TRIaD and QT to proarrhythmia

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QT and TdP. QT: an unreliable predictor of proarrhythmia

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Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic

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Discovery of a small molecule activator of the human ether-a-go-go-related gene (HERG) cardiac K+ channel

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7 January 2021

Atypical ventricular tachycardia (torsade de pointes) induced by amiodarone: arrhythmia previously induced by quinidine and disopyramide

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Nonclinical proarrhythmia models: predicting Torsades de Pointes

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Predicting drug-induced changes in QT interval and arrhythmias: QT-shortening drugs point to gaps in the ICHS7B Guidelines

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Q-aTc interval as a clinical indicator of hypercalcemia

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Cellular basis for arrhythmogenesis in an experimental model of the SQT1 form of the short QT syndrome

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A novel form of short QT syndrome (SQT3) is caused by a mutation in the KCNJ2 gene

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Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

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7 January 2021

Identifiers

10.1016/J.VASCN.2008.09.001

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Europe PubMed Central

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15 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18834945%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

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