(Q82385512)

English

Sildenafil treatment attenuates lung and kidney injury due to overproduction of oxidant activity in a rat model of sepsis: a biochemical and histopathological study

scientific article published on 01 December 2011

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scholarly article

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Europe PubMed Central

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16 January 2020

Sildenafil treatment attenuates lung and kidney injury due to overproduction of oxidant activity in a rat model of sepsis: a biochemical and histopathological study (English)

1 reference

Europe PubMed Central

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16 January 2020

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1 reference

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author name string

E Cadirci

1

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16 January 2020

Z Halici

2

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16 January 2020

F Odabasoglu

3

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16 January 2020

A Albayrak

4

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16 January 2020

E Karakus

5

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16 January 2020

D Unal

6

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16 January 2020

F Atalay

7

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16 January 2020

I Ferah

8

1 reference

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16 January 2020

B Unal

9

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16 January 2020

publication date

1 December 2011

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16 January 2020

Clinical and Experimental Immunology

1 reference

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16 January 2020

166

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16 January 2020

3

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16 January 2020

374-384

1 reference

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16 January 2020

PDE5A inhibition attenuates bleomycin-induced pulmonary fibrosis and pulmonary hypertension through inhibition of ROS generation and RhoA/Rho kinase activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of hepatic CYP inhibitors on the metabolism of sildenafil and formation of its metabolite, N-desmethylsildenafil, in rats in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathogenetic mechanisms of septic shock

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for carrier-mediated transport of glutathione across the blood-brain barrier in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress in skeletal muscle during sepsis in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of prostaglandin E1 (PGE1) and sildenafil on serotonin metabolism and some oxidative damage markers in rat prostate gland and brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of sildenafil on oxidative and inflammatory injuries of the kidney in streptozotocin-induced diabetic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma lipid peroxides and antioxidants in human septic shock

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A simple method for clinical assay of superoxide dismutase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokine modulation in sepsis and septic shock

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of montelukast on antioxidant enzymes and proinflammatory cytokines on the heart, liver, lungs, and kidneys in a rat model of cecal ligation and puncture-induced sepsis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative parameters and mortality in sepsis induced by cecal ligation and perforation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Strain-specific differences in perivascular inflammation in lungs in two murine models of allergic airway inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Free radicals and antioxidants in sepsis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Appearance of antidepressant-like effect by sildenafil in rats after central muscarinic receptor blockade: evidence from behavioural and neuro-receptor studies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of free radicals in sepsis development

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactive nitrogen species and tyrosine nitration in the respiratory tract: epiphenomena or a pathobiologic mechanism of disease?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of oxygen free radicals in shock

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute renal failure and sepsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of sildenafil in renal ischemia/reperfusion injury in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The new vitamin E derivative, ETS-GS, protects against cecal ligation and puncture-induced systemic inflammation in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cysteine metabolism and whole blood glutathione synthesis in septic pediatric patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effects of n-acetylcysteine on lung injury and red blood cell modification induced by carrageenan in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of sildenafil on cisplatin nephrotoxicity in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlation of plasma and tissue oxidative stresses in intra-abdominal sepsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Experimental therapeutic strategies for severe sepsis: mediators and mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphodiesterase-5 inhibition by sildenafil citrate in a rat model of bleomycin-induced lung fibrosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathological aspects of apoptosis in severe sepsis and shock?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sildenafil induces delayed preconditioning through inducible nitric oxide synthase-dependent pathway in mouse heart.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BAY 41-2272 inhibits the development of chronic hypoxic pulmonary hypertension in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measurement of Cutaneous Inflammation: Estimation of Neutrophil Content with an Enzyme Marker

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactive oxygen species in acute lung injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of pulmonary arterial hypertension

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sildenafil citrate and sildenafil nitrate (NCX 911) are potent inhibitors of superoxide formation and gp91phox expression in porcine pulmonary artery endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pathophysiology and treatment of sepsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prominent expression of phosphodiesterase 5 in striated muscle of the rat urethra and levator ani.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Statins: panacea for sepsis?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pathophysiology of septic shock

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of diabetes and/or polymicrobial sepsis on the status of antioxidant enzymes and pro-inflammatory cytokines on heart, liver, and lung of ovariectomized rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antidepressant-like properties of phosphodiesterase type 5 inhibitors and cholinergic dependency in a genetic rat model of depression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resistance to acute septic peritonitis in poly(ADP-ribose) polymerase-1-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early treatment with cGMP phosphodiesterase inhibitor ameliorates progression of renal damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of preoperative internal and external biliary drainage on mortality of jaundiced rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Time course of oxidative stress during open-heart surgery

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphodiesterase type 5 as a pharmacologic target in erectile dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Definition of sepsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sildenafil improves alveolar growth and pulmonary hypertension in hyperoxia-induced lung injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathophysiology of sepsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipid peroxide formation and membrane damage in endotoxin-poisoned mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-lipoic acid as a potential target for the treatment of lung injury caused by cecal ligation and puncture-induced sepsis model in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokine serum level during severe sepsis in human IL-6 as a marker of severity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of polymicrobial sepsis with diabetes mellitus on kidney tissues in ovariectomized rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of glutathione and N-acetylcysteine on lipoperoxidative damage in patients with early septic shock

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trauma: the role of the innate immune system

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Depletion of liver glutathione potentiates the oxidative stress and decreases nitric oxide synthesis in a rat endotoxin shock model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Does N-acetyl-L-cysteine influence cytokine response during early human septic shock?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidants, transcription factors, and intestinal inflammation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative variables in the rat brain after sepsis induced by cecal ligation and perforation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cecal ligation and puncture as a model of sepsis in the rat: influence of the puncture size on mortality, bacteremia, endotoxemia and tumor necrosis factor alpha levels.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo antioxidant treatment suppresses nuclear factor-kappa B activation and neutrophilic lung inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of sildenafil on maternal hemodynamics and fetal growth in normal rat pregnancy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1365-2249.2011.04483.X

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22059996%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22059996%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

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