(Q82485618)

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A phase I study of ispinesib, a kinesin spindle protein inhibitor, administered weekly for three consecutive weeks of a 28-day cycle in patients with solid tumors

scientific article published on 13 January 2010

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scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20069338%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

A phase I study of ispinesib, a kinesin spindle protein inhibitor, administered weekly for three consecutive weeks of a 28-day cycle in patients with solid tumors (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20069338%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

author name string

Howard A Burris

1

1 reference

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16 January 2020

Suzanne F Jones

2

1 reference

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16 January 2020

Daphne D Williams

3

1 reference

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16 January 2020

Steven J Kathman

4

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16 January 2020

Jeffrey P Hodge

5

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16 January 2020

Lini Pandite

6

1 reference

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16 January 2020

Peter T C Ho

7

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16 January 2020

Scott A Boerner

8

1 reference

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16 January 2020

Patricia Lorusso

9

1 reference

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16 January 2020

publication date

13 January 2010

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16 January 2020

Investigational New Drugs

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16 January 2020

29

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16 January 2020

3

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16 January 2020

467-472

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16 January 2020

https://scigraph.springernature.com/pub.10.1007/s10637-009-9374-x

0 references

Development of new cancer therapeutic agents targeting mitosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20069338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor activity of a kinesin inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/20069338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitotic kinesin inhibitors induce mitotic arrest and cell death in Taxol-resistant and -sensitive cancer cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20069338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An inhibitor of the kinesin spindle protein activates the intrinsic apoptotic pathway independently of p53 and de novo protein synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20069338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phase II study of ispinesib (SB-715992) in patients with metastatic or recurrent malignant melanoma: a National Cancer Institute of Canada Clinical Trials Group trial.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20069338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitotic kinesins: prospects for antimitotic drug discovery.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20069338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks

1 reference

https://pubmed.ncbi.nlm.nih.gov/20069338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Past and future of the mitotic spindle as an oncology target

1 reference

https://pubmed.ncbi.nlm.nih.gov/20069338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20069338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phase I trial of ispinesib, a kinesin spindle protein inhibitor, with docetaxel in patients with advanced solid tumours

1 reference

https://pubmed.ncbi.nlm.nih.gov/20069338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A bipolar kinesin

1 reference

https://pubmed.ncbi.nlm.nih.gov/20069338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/20069338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage

1 reference

https://pubmed.ncbi.nlm.nih.gov/20069338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of inhibition of human KSP by ispinesib

1 reference

https://pubmed.ncbi.nlm.nih.gov/20069338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II study of ispinesib in recurrent or metastatic squamous cell carcinoma of the head and neck

1 reference

https://pubmed.ncbi.nlm.nih.gov/20069338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of kinesin Eg5: antiproliferative activity of monastrol analogues against human glioblastoma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20069338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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