(Q82854230)

English

Discovery of 4-(4-(2-((5-Hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)amino)ethyl)piperazin-1-yl)quinolin-8-ol and its analogues as highly potent dopamine D2/D3 agonists and as iron chelator: in vivo activity indicates potential application in

scientific article published on 01 March 2010

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scholarly article

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Europe PubMed Central

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18 January 2020

Discovery of 4-(4-(2-((5-Hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)amino)ethyl)piperazin-1-yl)quinolin-8-ol and its analogues as highly potent dopamine D2/D3 agonists and as iron chelator: in vivo activity indicates potential application in symptomatic and neuroprotective therapy for Parkinson's disease (English)

1 reference

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18 January 2020

4

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18 January 2020

author name string

Balaram Ghosh

1

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18 January 2020

Tamara Antonio

2

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18 January 2020

Maarten E A Reith

3

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18 January 2020

publication date

1 March 2010

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18 January 2020

Journal of Medicinal Chemistry

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18 January 2020

53

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18 January 2020

2114-2125

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18 January 2020

5

1 reference

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18 January 2020

3,4-Dihydroxyphenylalanine and 5-hydroxytryptophan as reserpine antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and biological characterization of novel hybrid 7-[[2-(4-phenyl-piperazin-1-yl)-ethyl]-propyl-amino]-5,6,7,8-tetrahydro-naphthalen-2-ol and their heterocyclic bioisosteric analogues for dopamine D2 and D3 receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress promotes mutant huntingtin aggregation and mutant huntingtin-dependent cell death by mimicking proteasomal malfunction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction between iron(II) and hydroxamic acids: oxidation of iron(II) to iron(III) by desferrioxamine B under anaerobic conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sumanirole, a highly dopamine D2-selective receptor agonist: in vitro and in vivo pharmacological characterization and efficacy in animal models of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel bifunctional drugs targeting monoamine oxidase inhibition and iron chelation as an approach to neuroprotection in Parkinson's disease and other neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of iron in neurodegeneration: prospects for pharmacotherapy of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lead discovery and optimization of T-type calcium channel blockers

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ironing out Parkinson's disease: is therapeutic treatment with iron chelators a real possibility?

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydroxyquinolines as iron chelators

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of (S)-N6-(2-(4-(isoquinolin-1-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]-thiazole-2,6-diamine and its analogue as a D3 receptor preferring agonist: potent in vivo activity in Parkinson's disease animal models

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Further structure-activity relationships study of hybrid 7-{[2-(4-phenylpiperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol analogues: identification of a high-affinity D3-preferring agonist with potent in vivo activity with [...]

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The deoxyribose method: a simple "test-tube" assay for determination of rate constants for reactions of hydroxyl radicals

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

6-hydroxy-dopamine induced degeneration of central monoamine neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

S32504, a novel naphtoxazine agonist at dopamine D3/D2 receptors: II. Actions in rodent, primate, and cellular models of antiparkinsonian activity in comparison to ropinirole

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular pathophysiology of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: identification of highly potent and selective agonists for dopamine D3 receptor with potent in vivo activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of up-regulation of ferritin is associated with sustained iron regulatory protein-1 binding activity in the substantia nigra of patients with Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuromelanin induces oxidative stress in mitochondria through release of iron: mechanism behind the inhibition of 26S proteasome

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design, synthesis, and evaluation of novel bifunctional iron-chelators as potential agents for neuroprotection in Alzheimer's, Parkinson's, and other neurodegenerative diseases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotection by iron chelator against proteasome inhibitor-induced nigral degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxinobactin, a siderophore analogue to enterobactin involving 8-hydroxyquinoline subunits: synthesis and iron binding ability

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular Pathways of Neurodegeneration in Parkinson's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-synuclein in Lewy bodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Iron and Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain iron pathways and their relevance to Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

alpha-Synuclein implicated in Parkinson's disease catalyses the formation of hydrogen peroxide in vitro.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropathology of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neuropathologic basis of different clinical subgroups of Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recent advances in the genetics and pathogenesis of Parkinson disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spectrophotometric determination of serum iron at the submicrogram level with a new reagent (ferrozine)

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy

1 reference

https://pubmed.ncbi.nlm.nih.gov/20146482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM901618D

1 reference

Europe PubMed Central

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18 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20146482%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20146482%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

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