(Q82860891)

English

Aplidin induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 phosphatase downregulation

scientific article published on 17 March 2006

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scholarly article

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18 January 2020

Aplidin induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 phosphatase downregulation (English)

1 reference

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18 January 2020

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5

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18 January 2020

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18 January 2020

author name string

González-Santiago L

1

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18 January 2020

Suárez Y

2

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18 January 2020

Zarich N

3

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18 January 2020

Muñoz-Alonso MJ

4

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18 January 2020

Martínez T

6

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18 January 2020

Iradi A

8

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18 January 2020

Sáez-Tormo G

9

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18 January 2020

Maier JV

10

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18 January 2020

Moorthy A

11

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18 January 2020

Rojas JM

13

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18 January 2020

publication date

17 March 2006

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18 January 2020

Cell Death & Differentiation

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18 January 2020

13

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18 January 2020

1968-1981

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18 January 2020

11

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18 January 2020

https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401898

0 references

Structure--activity relationships of the didemnins.

1 reference

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7 January 2021

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In vitro activity of aplidine, a new marine-derived anti-cancer compound, on freshly explanted clonogenic human tumour cells and haematopoietic precursor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

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Aplidin induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

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Cell cycle phase perturbations and apoptosis in tumour cells induced by aplidine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

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Aplidin induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C delta

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

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JNK activation is critical for Aplidin-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

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Aplidine, a new anticancer agent of marine origin, inhibits vascular endothelial growth factor (VEGF) secretion and blocks VEGF-VEGFR-1 (flt-1) autocrine loop in human leukemia cells MOLT-4.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

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Antiangiogenic activity of aplidine, a new agent of marine origin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

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Effect of Aplidin in acute lymphoblastic leukaemia cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

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Neurotoxicity from glutathione depletion is dependent on extracellular trace copper

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

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Toxicity of glutathione depletion in mesencephalic cultures: a role for arachidonic acid and its lipoxygenase metabolites

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

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Regulation of JNK signaling by GSTp

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

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Reactive oxygen species mediate cytokine activation of c-Jun NH2-terminal kinases

1 reference

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7 January 2021

based on heuristic

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c-Jun NH2-terminal kinase-mediated activation of interleukin-1beta converting enzyme/CED-3-like protease during anticancer drug-induced apoptosis

1 reference

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7 January 2021

based on heuristic

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Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

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c-Jun N-terminal kinase activation by hydrogen peroxide in endothelial cells involves SRC-dependent epidermal growth factor receptor transactivation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

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The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

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Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

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Activation of RhoA and SAPK/JNK signalling pathways by the RhoA-specific exchange factor mNET1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

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Glutathione: toxicological implications

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

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Non-oxidative loss of glutathione in apoptosis via GSH extrusion.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

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Rescue of cells from apoptosis by inhibition of active GSH extrusion.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

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Rapid and specific efflux of reduced glutathione during apoptosis induced by anti-Fas/APO-1 antibody

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

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High-affinity transport of glutathione is part of a multicomponent system essential for mitochondrial function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

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Structure and regulation of MAPK phosphatases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

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Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

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Evidence that mitogen-activated protein kinase phosphatase-1 induction by proteasome inhibitors plays an antiapoptotic role

1 reference

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7 January 2021

based on heuristic

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Prologation of c-Jun N-terminal kinase is associated with cell death induced by tumor necrosis factor alpha in human chondrocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

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Inhibition of MKP-1 expression potentiates JNK related apoptosis in renal cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

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Overexpression of mitogen-activated protein kinase phosphatases MKP1, MKP2 in human breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

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Efficiency of homocysteine plus copper in inducing apoptosis is inversely proportional to gamma-glutamyl transpeptidase activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

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Oxytosis: A novel form of programmed cell death

1 reference

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inferred from DOI database lookup

The regulation of reactive oxygen species production during programmed cell death

1 reference

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7 January 2021

based on heuristic

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Role of glutathione in the induction of apoptosis and c-fos and c-jun mRNAs by oxidative stress in tumor cells.

1 reference

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Identification and quantitation of glutathione in hepatic protein mixed disulfides and its relationship to glutathione disulfide

1 reference

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Blood glutathione as an index of radiation-induced oxidative stress in mice and humans

1 reference

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based on heuristic

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A fluorometric method for determination of oxidized and reduced glutathione in tissues

1 reference

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HSos1 contains a new amino-terminal regulatory motif with specific binding affinity for its pleckstrin homology domain

1 reference

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Identifiers

10.1038/SJ.CDD.4401898

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18 January 2020

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18 January 2020

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