(Q83011317)

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The peroxisome proliferator-activated receptor (PPAR) β/δ agonist GW501516 inhibits IL-6-induced signal transducer and activator of transcription 3 (STAT3) activation and insulin resistance in human liver cells

scientific article published on 17 December 2011

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22179221%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

The peroxisome proliferator-activated receptor (PPAR) β/δ agonist GW501516 inhibits IL-6-induced signal transducer and activator of transcription 3 (STAT3) activation and insulin resistance in human liver cells (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22179221%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

insulin resistance

1 reference

based on heuristic

inferred from title

2

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22179221%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

author name string

L Serrano-Marco

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22179221%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

I El Kochairi

3

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22179221%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

X Palomer

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22179221%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

L Michalik

5

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Europe PubMed Central

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18 January 2020

W Wahli

6

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22179221%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

M Vázquez-Carrera

7

1 reference

Europe PubMed Central

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18 January 2020

publication date

17 December 2011

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22179221%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22179221%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

55

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Europe PubMed Central

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18 January 2020

3

1 reference

Europe PubMed Central

PubMed publication ID

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18 January 2020

743-751

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22179221%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Role of AMP kinase and PPARdelta in the regulation of lipid and glucose metabolism in human skeletal muscle.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Circulating interleukin 6 levels, blood pressure, and insulin sensitivity in apparently healthy men and women.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic and endocrine actions of interleukin-1. Effects on insulin-resistant animals.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Emerging roles of PPARs in inflammation and immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AMP-activated protein kinase signaling in metabolic regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Palmitate-mediated downregulation of peroxisome proliferator-activated receptor-gamma coactivator 1alpha in skeletal muscle cells involves MEK1/2 and nuclear factor-kappaB activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Obesity and insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Attenuation of leptin and insulin signaling by SOCS proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired expression of NADH dehydrogenase subunit 1 and PPARgamma coactivator-1 in skeletal muscle of ZDF rats: restoration by troglitazone

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-6 signal transduction and its physiological roles: the signal orchestration model

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-6 induces cellular insulin resistance in hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nutrient stress activates inflammation and reduces glucose metabolism by suppressing AMP-activated protein kinase in the heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of peroxisome proliferator-activated receptor-β/-δ (PPAR-β/-δ) ameliorates insulin signaling and reduces SOCS3 levels by inhibiting STAT3 in interleukin-6-stimulated adipocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Berberine suppresses neuroinflammatory responses through AMP-activated protein kinase activation in BV-2 microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A unified nomenclature system for the nuclear receptor superfamily

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of STATs in transcriptional control and their impact on cellular function

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The PPARβ/δ activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-Lipin 1-PPARα pathway leading to increased fatty acid oxidation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-6 and tumor necrosis factor-alpha are not increased in patients with Type 2 diabetes: evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SOCS: physiological suppressors of cytokine signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AMP-activated protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of transcription 3 (STAT3).

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative RT-PCR: pitfalls and potential

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Requirement of serine phosphorylation for formation of STAT-promoter complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-6 and insulin sensitivity: friend or foe?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPAR delta: a dagger in the heart of the metabolic syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The PPARdelta agonist GW501516 suppresses interleukin-6-mediated hepatocyte acute phase reaction via STAT3 inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serine phosphorylation of STATs

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitory crosstalk between ERK and AMPK in the growth and proliferation of cardiac fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor beta/delta

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-6 depletion selectively improves hepatic insulin action in obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of interleukin-6-induced hepatic insulin resistance by mammalian target of rapamycin through the STAT3-SOCS3 pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Principles of interleukin (IL)-6-type cytokine signalling and its regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dose-dependent effects of recombinant human interleukin-6 on glucose regulation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SOCS-3 is an insulin-induced negative regulator of insulin signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/22179221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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