(Q83282038)

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Characterization of the functional epitope on the urokinase receptor. Complete alanine scanning mutagenesis supplemented by chemical cross-linking

scientific article published on 03 May 2006

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20 January 2020

Characterization of the functional epitope on the urokinase receptor. Complete alanine scanning mutagenesis supplemented by chemical cross-linking (English)

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20 January 2020

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Thomas J.D. Jørgensen

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20 January 2020

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20 January 2020

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Henrik Gårdsvoll

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20 January 2020

Bernard Gilquin

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20 January 2020

Marie Hélène Le Du

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20 January 2020

Andre Ménèz

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3 May 2006

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20 January 2020

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13

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Journal of Biological Chemistry

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20 January 2020

19260-19272

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20 January 2020

Collagen dissolution by keratinocytes requires cell surface plasminogen activation and matrix metalloproteinase activity

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Convergence of the adhesive and fibrinolytic systems: recognition of urokinase by integrin alpha Mbeta 2 as well as by the urokinase receptor regulates cell adhesion and migration

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Regulation of integrin function by the urokinase receptor

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Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding.

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EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma

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The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R.

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Plasma Urokinase Receptor Levels in Patients With Colorectal Cancer: Relationship to Prognosis

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21 January 2018

The urokinase receptor as a potential target in cancer therapy.

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Urokinase-type plasminogen activator (uPA) and its receptor (uPAR): development of antagonists of uPA/uPAR interaction and their effects in vitro and in vivo

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21 January 2018

Inhibitors of the proteolytic activity of urokinase type plasminogen activator

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21 January 2018

Targeting urokinase-type plasminogen activator receptor on human glioblastoma tumors with diphtheria toxin fusion protein DTAT.

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High-affinity urokinase receptor antagonists identified with bacteriophage peptide display

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Peptide-derived antagonists of the urokinase receptor. affinity maturation by combinatorial chemistry, identification of functional epitopes, and inhibitory effect on cancer cell intravasation

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21 January 2018

Synthesis, solution structure, and biological evaluation of urokinase type plasminogen activator (uPA)-derived receptor binding domain mimetics

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21 January 2018

Inhibition of invasion, angiogenesis, tumor growth, and metastasis by adenovirus-mediated transfer of antisense uPAR and MMP-9 in non-small cell lung cancer cells.

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21 January 2018

RNA interference-directed knockdown of urokinase plasminogen activator and urokinase plasminogen activator receptor inhibits prostate cancer cell invasion, survival, and tumorigenicity in vivo

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21 January 2018

Potent antitumor activity of a urokinase-activated engineered anthrax toxin

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21 January 2018

Chemical modification of the urokinase-type plasminogen activator and its receptor using tetranitromethane. Evidence for the involvement of specific tyrosine residues in both molecules during receptor-ligand interaction

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21 January 2018

Mapping part of the functional epitope for ligand binding on the receptor for urokinase-type plasminogen activator by site-directed mutagenesis

1 reference

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21 January 2018

A region in domain II of the urokinase receptor required for urokinase binding

1 reference

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21 January 2018

Structure-function relationships in the interaction between the urokinase-type plasminogen activator and its receptor

1 reference

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21 January 2018

Dynamics of urokinase receptor interaction with Peptide antagonists studied by amide hydrogen exchange and mass spectrometry

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21 January 2018

Ligand binding regions in the receptor for urokinase-type plasminogen activator

1 reference

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21 January 2018

Sequences within domain II of the urokinase receptor critical for differential ligand recognition

1 reference

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21 January 2018

Removal of domain D2 or D3 of the human urokinase receptor does not affect ligand affinity

1 reference

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21 January 2018

Ligand interaction between urokinase-type plasminogen activator and its receptor probed with 8-anilino-1-naphthalenesulfonate. Evidence for a hydrophobic binding site exposed only on the intact receptor

1 reference

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21 January 2018

Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide

1 reference

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21 January 2018

Characterization of low-glycosylated forms of soluble human urokinase receptor expressed in Drosophila Schneider 2 cells after deletion of glycosylation-sites.

1 reference

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21 January 2018

A novel MALDI LIFT-TOF/TOF mass spectrometer for proteomics

1 reference

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21 January 2018

Quantitation of the receptor for urokinase plasminogen activator by enzyme-linked immunosorbent assay

1 reference

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21 January 2018

Amino acid analysis: determination of cysteine plus half-cystine in proteins after hydrochloric acid hydrolysis with a disulfide compound as additive

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Kinetic analysis of monoclonal antibody-antigen interactions with a new biosensor based analytical system

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Identification of cross-linked peptides for protein interaction studies using mass spectrometry and 18O labeling

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21 January 2018

Modeling the structure of agitoxin in complex with the Shaker K+ channel: a computational approach based on experimental distance restraints extracted from thermodynamic mutant cycles

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All-atom empirical potential for molecular modeling and dynamics studies of proteins

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21 January 2018

Solution structure of the amino-terminal fragment of urokinase-type plasminogen activator

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Structure-function relationships in the receptor for urokinase-type plasminogen activator. Comparison to other members of the Ly-6 family and snake venom alpha-neurotoxins

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21 January 2018

Comparison of a structural and a functional epitope

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Induced fit of an epitope peptide to a monoclonal antibody probed with a novel parallel surface plasmon resonance assay

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Chemical cross-linking and mass spectrometry for mapping three-dimensional structures of proteins and protein complexes

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Chemical cross-linking and mass spectrometry for protein structural modeling.

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Systematic mutational analysis of the receptor-binding region of the human urokinase-type plasminogen activator.

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Domain interplay in the urokinase receptor. Requirement for the third domain in high affinity ligand binding and demonstration of ligand contact sites in distinct receptor domains.

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A hot spot of binding energy in a hormone-receptor interface

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Analysis of the ternary complex formation of human urokinase with the separated two domains of its receptor

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Photoaffinity labeling of the human receptor for urokinase-type plasminogen activator using a decapeptide antagonist. Evidence for a composite ligand-binding site and a short interdomain separation

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21 January 2018

Structure of human urokinase plasminogen activator in complex with its receptor

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Identifiers

10.1074/JBC.M513583200

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16672229%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16672229%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

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