(Q83385514)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21300029%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

title

A comprehensive understanding of thioTEPA metabolism in the mouse using UPLC-ESI-QTOFMS-based metabolomics (English)

1 reference

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21 January 2020

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2

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21 January 2020

Jeff Idle

6

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21 January 2020

author name string

Fei Li

1

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21 January 2020

Constance C Höfer

3

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21 January 2020

Kristopher W Krausz

4

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21 January 2020

Frank J Gonzalez

5

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21 January 2020

publication date

12 February 2011

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21 January 2020

published in

Biochemical Pharmacology

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21 January 2020

volume

81

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21 January 2020

issue

8

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21 January 2020

page(s)

1043-1053

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Degradation study of thiotepa in aqueous solutions.

21 January 2020

cites work

1 reference

12 December 2020

A search for new metabolites of N,N',N''-triethylenethiophosphoramide

1 reference

12 December 2020

The degradation of N,N',N"-triethylenephosphoramide in aqueous solutions: a qualitative and kinetic study

1 reference

12 December 2020

Chemistry, pharmacology and pharmacokinetics of N,N',N" -triethylenethiophosphoramide (ThioTEPA)

1 reference

12 December 2020

Urinary excretion of thioTEPA and its metabolites in patients treated with high-dose cyclophosphamide, thioTEPA and carboplatin

1 reference

12 December 2020

Insights into the mechanisms of ifosfamide encephalopathy: drug metabolites have agonistic effects on alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors and induce cellular acidification in mouse cortical neurons

1 reference

12 December 2020

Cytochrome P450 isozymes 3A4 and 2B6 are involved in the in vitro human metabolism of thiotepa to TEPA.

1 reference

12 December 2020

Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYP2D6.

1 reference

12 December 2020

Acute encephalopathy due to thiamine deficiency with hyperammonemia in a chronic hemodialysis patient: a case report

1 reference

12 December 2020

Understanding 'Global' Systems Biology: Metabonomics and the Continuum of Metabolism

1 reference

12 December 2020

Breast cancer; a new approach to therapy.

1 reference

12 December 2020

Alkylation of DNA with aziridine produced during the hydrolysis of N,N',N''-triethylenethiophosphoramide

1 reference

12 December 2020

Cerebral formation in situ of S-carboxymethylcysteine after ifosfamide administration to mice: a further clue to the mechanism of ifosfamide encephalopathy

1 reference

12 December 2020

Identification of thiodiglycolic acid, thiodiglycolic acid sulfoxide, and (3-carboxymethylthio)lactic acid as major human biotransformation products of S-carboxymethyl-L-cysteine

1 reference

12 December 2020

Severe encephalopathy after high-dose chemotherapy with autologous stem cell support for brain tumours

1 reference

12 December 2020

A metabolomic approach to the metabolism of the areca nut alkaloids arecoline and arecaidine in the mouse

1 reference

12 December 2020

Pancreatic encephalopathy and Wernicke encephalopathy in association with acute pancreatitis: a clinical study

1 reference

12 December 2020

Long-term pharmacokinetics of thio-TEPA, TEPA and total alkylating activity following i. v. bolus administration of thio-TEPA in ovarian cancer patients

1 reference

12 December 2020

N,N',N''-triethylenethiophosphoramide (thio-TEPA) oxygenation by constitutive hepatic P450 enzymes and modulation of drug metabolism and clearance in vivo by P450-inducing agents

1 reference

12 December 2020

Phase I/pharmacokinetic reevaluation of thioTEPA

1 reference

12 December 2020

Interaction of N,N',N''-triethylenethiophosphoramide and N,N',N''-triethylenephosphoramide with cellular DNA

1 reference

12 December 2020

Role of thiamine in managing ifosfamide-induced encephalopathy.

1 reference

12 December 2020

1 reference

12 December 2020

Direct observation of the alkylation products of deoxyguanosine and DNA by fast atom bombardment mass spectrometry

1 reference

12 December 2020

Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice

1 reference

12 December 2020

A metabolomic perspective of melatonin metabolism in the mouse

1 reference

12 December 2020

Effects of thiamine and benfotiamine on intracellular glucose metabolism and relevance in the prevention of diabetic complications

1 reference

12 December 2020

Wernicke's encephalopathy and pancreatic encephalopathy after necrotic-hemorrhagic pancreatitis. A case report.

1 reference

12 December 2020

Xenobiotic metabolism: a view through the metabolometer

1 reference

12 December 2020

Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC-ESI-QTOFMS-based metabolomics.

1 reference

12 December 2020

Acetyl-CoA deficit in brain mitochondria in experimental thiamine deficiency encephalopathy

1 reference

12 December 2020

Biotransformation of N,N',N''-triethylenethiophosphoramide: oxidative desulfuration to yield N,N',N''-triethylenephosphoramide associated with suicide inactivation of a phenobarbital-inducible hepatic P-450 monooxygenase

1 reference

12 December 2020

High-dose N,N',N"-triethylenethiophosphoramide (thiotepa) with autologous bone marrow transplantation: phase I studies.

1 reference

12 December 2020

Human plasma pharmacokinetics and urinary excretion of thiotepa and its metabolites

1 reference

12 December 2020

Liquid chromatography-thermospray mass spectrometry of DNA adducts formed with mitomycin C, porfiromycin and thiotepa

1 reference

12 December 2020

Combination of N,N',N"-triethylenethiophosphoramide and cyclophosphamide in vitro and in vivo

1 reference

12 December 2020

Thiotepa in the treatment of advanced breast cancer

1 reference

12 December 2020

Encephalopathy of thiamine deficiency: studies of intracerebral mechanisms

1 reference

12 December 2020

Effects of pH and temperature on the stability and decomposition of N,N'N"-triethylenethiophosphoramide in urine and buffer

1 reference

12 December 2020

The role of human glutathione S-transferase isoenzymes in the formation of glutathione conjugates of the alkylating cytostatic drug thiotepa.

1 reference

12 December 2020

Thiodiglycolic acid is excreted by humans receiving ifosfamide and inhibits mitochondrial function in rats.

1 reference

12 December 2020

Rapidly cycled courses of high-dose alkylating agents supported by filgrastim and peripheral blood progenitor cells in patients with metastatic breast cancer

1 reference

12 December 2020

High-dose thiotepa and etoposide-based regimens with autologous hematopoietic support for high-risk or recurrent CNS tumors in children and adults.

1 reference

12 December 2020

10.1016/J.BCP.2011.01.024

Identifiers

DOI

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21 January 2020

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21 January 2020

PubMed publication ID

21300029

1 reference