(Q36497616)

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Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice (English)

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Chi Chen

1

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Kristopher W Krausz

2

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Jeffrey R Idle

3

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Frank J Gonzalez

4

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

language of work or name

0 references

publication date

19 December 2007

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

283

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

8

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

4543-4559

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

LC-MS-based metabolomics in drug metabolism

1 reference

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30 September 2017

A comprehensive investigation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) metabolism in the mouse using a multivariate data analysis approach

1 reference

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30 September 2017

A metabolomic approach to the metabolism of the areca nut alkaloids arecoline and arecaidine in the mouse

1 reference

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30 September 2017

Urinary metabolite profiling reveals CYP1A2-mediated metabolism of NSC686288 (aminoflavone).

1 reference

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30 September 2017

Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268247

30 September 2017

Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268247

30 September 2017

Acetaminophen-induced hepatotoxicity: role of metabolic activation, reactive oxygen/nitrogen species, and mitochondrial permeability transition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268247

30 September 2017

Cyp1a2 protects against reactive oxygen production in mouse liver microsomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268247

30 September 2017

Metabonomics: a platform for studying drug toxicity and gene function

1 reference

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30 September 2017

Nephrotoxicity after acute severe acetaminophen poisoning in adolescents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268247

30 September 2017

Inhibition of neuronal nitric oxide synthase by 6-nitrocatecholamines, putative reaction products of nitric oxide with catecholamines under oxidative stress conditions

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268247

30 September 2017

https://pubmed.ncbi.nlm.nih.gov/18093979

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Melanins, melanogenesis and melanocytes: looking at their functional significance from the chemist's viewpoint

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268247

30 September 2017

N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268247

30 September 2017

The regulation of hepatic glutathione

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268247

30 September 2017

Origin and turnover of mitochondrial glutathione

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268247

30 September 2017

Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268247

30 September 2017

Purification and characterization of cysteine conjugate transaminases from rat liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268247

30 September 2017

Evolutionary and biosynthetic aspects of aspartate aminotransferase isoenzymes and other aminotransferases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268247

30 September 2017

Oxidative and reductive metabolism by cytochrome P450 2E1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268247

30 September 2017

Cytochrome P-4502E1: its physiological and pathological role

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268247

30 September 2017

Urinary excretion of acetaminophen and its metabolites as studied by proton NMR spectroscopy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268247

28 June 2018

Acetaminophen-induced hepatic necrosis. V. Correlation of hepatic necrosis, covalent binding and glutathione depletion in hamsters.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268247

28 June 2018

Cytochrome P-450 isozyme selectivity in the oxidation of acetaminophen.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268247

28 June 2018

Distribution and metabolism of the natural anticarcinogen phenethyl isothiocyanate in A/J mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268247

28 June 2018

Comparative cytotoxic effects of acetaminophen (N-acetyl-p-aminophenol), a non-hepatotoxic regioisomer acetyl-m-aminophenol and their postulated reactive hydroquinone and quinone metabolites in monolayer cultures of mouse hepatocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268247

28 June 2018

The cyp2e1-humanized transgenic mouse: role of cyp2e1 in acetaminophen hepatotoxicity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706299200

21 January 2018

Integrated application of transcriptomics and metabonomics yields new insight into the toxicity due to paracetamol in the mouse

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706299200

21 January 2018

An integrated metabonomic investigation of acetaminophen toxicity in the mouse using NMR spectroscopy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706299200

21 January 2018

Serum transaminase elevations as indicators of hepatic injury following the administration of drugs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706299200

21 January 2018

Alcohol-mediated increases in acetaminophen hepatotoxicity: role of CYP2E and CYP3A.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706299200

21 January 2018

Enhanced acetaminophen toxicity by activation of the pregnane X receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706299200

21 January 2018

Peroxynitrite is a critical mediator of acetaminophen hepatotoxicity in murine livers: protection by glutathione

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706299200

21 January 2018

Mechanisms of acetaminophen-induced hepatotoxicity: role of oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706299200

21 January 2018

Detoxification of reactive oxygen species by a nonpeptidyl mimic of superoxide dismutase cures acetaminophen-induced acute liver failure in the mouse

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706299200

21 January 2018

Contribution of acetaminophen-cysteine to acetaminophen nephrotoxicity in CD-1 mice: I. Enhancement of acetaminophen nephrotoxicity by acetaminophen-cysteine

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706299200

21 January 2018

Understanding 'Global' Systems Biology: Metabonomics and the Continuum of Metabolism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706299200

21 January 2018

Identification of acetaminophen polymerization products catalyzed by horseradish peroxidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268247

21 September 2018

Metabolite profiling: from diagnostics to systems biology

1 reference

https://pubmed.ncbi.nlm.nih.gov/18093979

12 December 2020

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inferred from PubMed ID database lookup

On the stoichiometry of the oxidase and monooxygenase reactions catalyzed by liver microsomal cytochrome P-450. Products of oxygen reduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/18093979

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The formation and toxicity of catechol metabolites of acetaminophen in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18093979

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The 1- and 2-electron oxidation of acetaminophen catalyzed by prostaglandin H synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18093979

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P-450 (P-450IIE1)

1 reference

https://pubmed.ncbi.nlm.nih.gov/18093979

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2

1 reference

https://pubmed.ncbi.nlm.nih.gov/18093979

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative cyclization, 1,4-benzothiazine formation and dimerization of 2-bromo-3-(glutathion-S-yl)hydroquinone

1 reference

https://pubmed.ncbi.nlm.nih.gov/18093979

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/18093979

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of CYP2E1 and CYP1A2 activity as a function of acetaminophen dose: relation to toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18093979

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical localization of acetaminophen in target tissues of the CD-1 mouse: correspondence of covalent binding with toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18093979

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of CYP2E1 in the hepatotoxicity of acetaminophen

1 reference

https://pubmed.ncbi.nlm.nih.gov/18093979

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of multiple forms of inducible cytochromes P450 in rat liver mitochondria: immunological characteristics and patterns of xenobiotic substrate metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/18093979

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidation of acetaminophen to its toxic quinone imine and nontoxic catechol metabolites by baculovirus-expressed and purified human cytochromes P450 2E1 and 2A6

1 reference

https://pubmed.ncbi.nlm.nih.gov/18093979

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18093979

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1(-/-) mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18093979

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M706299200

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

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