(Q31097755)

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A comprehensive investigation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) metabolism in the mouse using a multivariate data analysis approach

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scholarly article

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Europe PubMed Central

PMC publication ID

13 October 2017

A comprehensive investigation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) metabolism in the mouse using a multivariate data analysis approach (English)

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Europe PubMed Central

PMC publication ID

13 October 2017

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multivariate statistics

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inferred from title

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Chi Chen

1

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author name string

Xiaochao Ma

2

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Europe PubMed Central

PMC publication ID

13 October 2017

Michael A Malfatti

3

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Europe PubMed Central

PMC publication ID

13 October 2017

Kristopher W Krausz

4

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Shioko Kimura

5

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Europe PubMed Central

PMC publication ID

13 October 2017

James S Felton

6

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Europe PubMed Central

PMC publication ID

13 October 2017

Jeffrey R Idle

7

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Europe PubMed Central

PMC publication ID

13 October 2017

Frank J Gonzalez

8

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Europe PubMed Central

PMC publication ID

13 October 2017

publication date

6 February 2007

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Europe PubMed Central

PMC publication ID

13 October 2017

Chemical Research in Toxicology

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Europe PubMed Central

PMC publication ID

13 October 2017

20

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Europe PubMed Central

PMC publication ID

13 October 2017

3

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

531-542

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Mouse lung CYP1A1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Role of gene knockout and transgenic mice in the study of xenobiotic metabolism

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Heterocyclic aromatic amine metabolism, DNA adduct formation, mutagenesis, and carcinogenesis

1 reference

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N-glucuronidation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and N_hydroxy-PhIP by specific human UDP-glucuronosyltransferases

1 reference

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Interspecies differences in metabolism of heterocyclic aromatic amines by rat and human P450 1A2

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Cytochrome P450 CYP1B1 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomas

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Metabolism of food-derived heterocyclic amines in nonhuman primates.

1 reference

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21 June 2018

Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat.

1 reference

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Glucuronidation of N-hydroxy heterocyclic amines by human and rat liver microsomes.

1 reference

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Neonatal lethality associated with respiratory distress in mice lacking cytochrome P450 1A2

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Monoclonal antibodies to rat liver cytochrome P-450 2c/RLM5 that regiospecifically inhibit steroid metabolism.

1 reference

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21 June 2018

Differential rates of metabolic activation and detoxication of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by different cytochrome P450 enzymes

1 reference

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21 June 2018

Presence of carcinogenic heterocyclic amines in urine of healthy volunteers eating normal diet, but not of inpatients receiving parenteral alimentation.

1 reference

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Induction of lymphoma in CDF1 mice by the food mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

1 reference

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Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice humanized for CYP1A1 and CYP1A2.

1 reference

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The impact of glucuronidation on the bioactivation and DNA adduction of the cooked-food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in vivo

1 reference

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4-aminobiphenyl-induced liver and urinary bladder DNA adduct formation in Cyp1a2(-/-) and Cyp1a2(+/+) mice

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Carcinogenesis of the food mutagen PhIP in mice is independent of CYP1A2.

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Contribution of individual cytochrome P450 isozymes to the O-demethylation of the psychotropic beta-carboline alkaloids harmaline and harmine.

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2-Amino-1-methyl-6-(5-hydroxy-)phenylimidazo[4,5-b]pyridine (5-OH-PhIP), a biomarker for the genotoxic dose of the heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).

1 reference

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Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rat and human hepatocytes

1 reference

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1 reference

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1 reference

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1 reference

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In vitro formation and degradation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) protein adducts.

1 reference

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1 reference

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https://pubmed.ncbi.nlm.nih.gov/17279779

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inferred from PubMed ID database lookup

32P Postlabelling analysis of urinary mutagens from smokers of black tobacco implicates 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) as a major DNA-damaging agent

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279779

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The direct glucuronidation of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) by human and rabbit liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279779

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inferred from PubMed ID database lookup

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10.1021/TX600320W

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

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