(Q83415937)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22321701%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

title

In silico methods combined with expert knowledge rule out mutagenic potential of pharmaceutical impurities: an industry survey (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22321701%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

1 reference

Krista L Dobo

1

1 reference

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22 January 2020

Nigel Greene

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22321701%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Charlotta Fred

3

1 reference

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22 January 2020

Susanne Glowienke

4

1 reference

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22 January 2020

James S Harvey

5

1 reference

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22 January 2020

Catrin Hasselgren

6

1 reference

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22 January 2020

Robert Jolly

7

1 reference

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22 January 2020

Michelle O Kenyon

8

1 reference

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22 January 2020

Jennifer B Munzner

9

1 reference

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22 January 2020

Wolfgang Muster

10

1 reference

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22 January 2020

Robin Neft

11

1 reference

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22 January 2020

M Vijayaraj Reddy

12

1 reference

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22 January 2020

Angela T White

13

1 reference

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22 January 2020

Sandy Weiner

14

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22 January 2020

publication date

31 January 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22321701%20AND%20SRC:MED&resulttype=core&format=json

Regulatory Toxicology and Pharmacology

22 January 2020

published in

1 reference

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22 January 2020

volume

62

1 reference

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22 January 2020

issue

3

1 reference

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22 January 2020

page(s)

449-455

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22321701%20AND%20SRC:MED&resulttype=core&format=json

Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U.S. NTP

22 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2012.01.007

The application of structure-based assessment to support safety and chemistry diligence to manage genotoxic impurities in active pharmaceutical ingredients during drug development.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2012.01.007

Knowledge-based expert systems for toxicity and metabolism prediction: DEREK, StAR and METEOR.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2012.01.007

Computer systems for the prediction of toxicity: an update

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2012.01.007

Benchmark data set for in silico prediction of Ames mutagenicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2012.01.007

Comparative evaluation of in silico systems for ames test mutagenicity prediction: scope and limitations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2012.01.007

A new highly specific method for predicting the carcinogenic potential of pharmaceuticals in rodents using enhanced MCASE QSAR-ES software

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2012.01.007

Combined Use of MC4PC, MDL-QSAR, BioEpisteme, Leadscope PDM, and Derek for Windows Software to Achieve High-Performance, High-Confidence, Mode of Action-Based Predictions of Chemical Carcinogenesis in Rodents.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2012.01.007

A rationale for determining, testing, and controlling specific impurities in pharmaceuticals that possess potential for genotoxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2012.01.007

The computational prediction of genotoxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2012.01.007

Integration of computational analysis as a sentinel tool in toxicological assessments

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2012.01.007

Computer prediction of possible toxic action from chemical structure: an update on the DEREK system.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2012.01.007

Evaluating the ability of CASE, an artificial intelligence structure-activity relational system, to predict structural alerts for genotoxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2012.01.007

Structural relationships between mutagenicity, maximum tolerated dose, and carcinogenicity in rodents.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2012.01.007

Benchmark performance of MultiCASE Inc. software in Ames mutagenicity set.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2012.01.007

Computer Prediction of Possible Toxic Action from Chemical Structure; The DEREK System

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2012.01.007

An update on the genotoxicity and carcinogenicity of marketed pharmaceuticals with reference to in silico predictivity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2012.01.007

Assessment of the sensitivity of the computational programs DEREK, TOPKAT, and MCASE in the prediction of the genotoxicity of pharmaceutical molecules.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2012.01.007

A multiple in silico program approach for the prediction of mutagenicity from chemical structure.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2012.01.007

10.1016/J.YRTPH.2012.01.007

7 January 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22321701%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

1 reference