(Q83437651)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19266525%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

title

Pharmacological promiscuity: dependence on compound properties and target specificity in a set of recent Roche compounds (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19266525%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

author name string

Jens-Uwe Peters

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19266525%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Patrick Schnider

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19266525%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Patrizio Mattei

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19266525%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Manfred Kansy

4

1 reference

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22 January 2020

publication date

1 April 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19266525%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

number of pages

7

1 reference

inferred from page(s)

published in

ChemMedChem

1 reference

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22 January 2020

volume

4

1 reference

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22 January 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19266525%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

page(s)

680-686

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19266525%20AND%20SRC:MED&resulttype=core&format=json

Duloxetine: a new selective and dual-acting antidepressant

22 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800411

7 January 2021

Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800411

7 January 2021

"Promiscuous" anticancer drugs that hit multiple targets may thwart resistance.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800411

7 January 2021

Appetite-suppressant drugs and the risk of primary pulmonary hypertension. International Primary Pulmonary Hypertension Study Group

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800411

7 January 2021

Fatal pulmonary hypertension associated with short-term use of fenfluramine and phentermine

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800411

7 January 2021

The fenfluramine metabolite (+)-norfenfluramine is vasoactive

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800411

7 January 2021

Valvular heart disease associated with fenfluramine-phentermine

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800411

7 January 2021

Keynote review: in vitro safety pharmacology profiling: an essential tool for successful drug development

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800411

7 January 2021

Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800411

7 January 2021

Modeling promiscuity based on in vitro safety pharmacology profiling data

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800411

7 January 2021

https://api.crossref.org/works/10.1002%2FCMDC.200800411

1 reference

7 January 2021

Data completeness—the Achilles heel of drug-target networks

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800411

7 January 2021

Can we rationally design promiscuous drugs?

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800411

7 January 2021

The influence of drug-like concepts on decision-making in medicinal chemistry

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800411

7 January 2021

Pyridyl-phenyl ether monoamine reuptake inhibitors: Impact of lipophilicity on dual SNRI pharmacology and off-target promiscuity

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800411

7 January 2021

A virtual screening method for prediction of the HERG potassium channel liability of compound libraries

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800411

7 January 2021

Are hERG channel inhibition and QT interval prolongation all there is in drug-induced torsadogenesis? A review of emerging trends

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800411

7 January 2021

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800411

7 January 2021

Metabolic screening in vitro: metabolic stability, CYP inhibition and induction

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800411

7 January 2021

Inhibition and induction of cytochrome P450 and the clinical implications

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800411

7 January 2021

Development of a virtual screening method for identification of "frequent hitters" in compound libraries

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800411

7 January 2021

Information decay in molecular docking screens against holo, apo, and modeled conformations of enzymes

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800411

7 January 2021

A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800411

7 January 2021

Molecular complexity and its impact on the probability of finding leads for drug discovery

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800411

7 January 2021

A ligand-based approach to mining the chemogenomic space of drugs

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800411

7 January 2021

Biological assay challenges from compound solubility: strategies for bioassay optimization

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800411

7 January 2021

New and Original pKaPrediction Method Using Grid Molecular Interaction Fields

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800411

7 January 2021

Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800411

7 January 2021

Multiwavelength spectrophotometric determination of acid dissociation constants of ionizable drugs

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800411

7 January 2021

Identifiers

DOI

10.1002/CMDC.200800411

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19266525%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

1 reference