(Q28222762)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17477341%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

title

Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure (English)

1 reference

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30 December 2019

1 reference

2

1 reference

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30 December 2019

Jeremy L. Jenkins

9

1 reference

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30 December 2019

1

Andreas Bender

1 reference

30 December 2019

Meir Glick

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17477341%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

John W Davies

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17477341%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

Kamal Azzaoui

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17477341%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

Jacques Hamon

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17477341%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

Laszlo Urban

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17477341%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

Steven Whitebread

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17477341%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

language of work or name

English

0 references

publication date

1 June 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17477341%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17477341%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

volume

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17477341%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17477341%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

page(s)

861-873

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17477341%20AND%20SRC:MED&resulttype=core&format=json

Can the pharmaceutical industry reduce attrition rates?

30 December 2019

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Timing of new black box warnings and withdrawals for prescription medications

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Exercise and diet reduce risk of diabetes, US study shows

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7 January 2021

Lessons from the withdrawal of rofecoxib

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7 January 2021

An EU perspective on the use of in vitro methods in regulatory pharmaceutical toxicology

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The role of pharmacological profiling in safety assessment

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Origins, practices and future of safety pharmacology

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Keynote review: in vitro safety pharmacology profiling: an essential tool for successful drug development

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7 January 2021

The application of in vitro methods to safety pharmacology

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7 January 2021

A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

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7 January 2021

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

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7 January 2021

A virtual screening method for prediction of the HERG potassium channel liability of compound libraries

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7 January 2021

Are hERG channel inhibition and QT interval prolongation all there is in drug-induced torsadogenesis? A review of emerging trends

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7 January 2021

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

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7 January 2021

Predicting undesirable drug interactions with promiscuous proteins in silico

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7 January 2021

A pharmacophore for human pregnane X receptor ligands

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7 January 2021

Modeling promiscuity based on in vitro safety pharmacology profiling data

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7 January 2021

Information decay in molecular docking screens against holo, apo, and modeled conformations of enzymes

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7 January 2021

A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

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7 January 2021

Development of a virtual screening method for identification of "frequent hitters" in compound libraries

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7 January 2021

The efficiency of multi-target drugs: the network approach might help drug design

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7 January 2021

Designed multiple ligands. An emerging drug discovery paradigm

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7 January 2021

Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches

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7 January 2021

GPCR antitarget modeling: pharmacophore models for biogenic amine binding GPCRs to avoid GPCR-mediated side effects

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7 January 2021

Progress toward virtual screening for drug side effects.

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7 January 2021

Biospectra analysis: model proteome characterizations for linking molecular structure and biological response

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7 January 2021

Analysis of drug-induced effect patterns to link structure and side effects of medicines

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7 January 2021

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7 January 2021

Prediction of biological targets for compounds using multiple-category Bayesian models trained on chemogenomics databases.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700026

7 January 2021

Bridging chemical and biological space: "target fishing" using 2D and 3D molecular descriptors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700026

7 January 2021

Upper gastrointestinal bleeding associated with antiplatelet drugs

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700026

7 January 2021

Acetylsalicylic acid does not alter the mechanoelectrical transduction of mammalian outer hair cells in vitro

1 reference

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7 January 2021

1 reference

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7 January 2021

H1-antihistamines: inverse agonism, anti-inflammatory actions and cardiac effects

1 reference

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7 January 2021

"Bayes affinity fingerprints" improve retrieval rates in virtual screening and define orthogonal bioactivity space: when are multitarget drugs a feasible concept?

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7 January 2021

Opioids for chronic noncancer pain: a meta-analysis of effectiveness and side effects.

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7 January 2021

Muscarinic Receptor Agonists and Antagonists.

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7 January 2021

Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition.

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7 January 2021

Inhibition of cyclooxygenase-2 reduces the protective effect of hepatocyte growth factor in experimental pancreatitis

1 reference

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7 January 2021

The antipsychotic drug chlorpromazine inhibits HERG potassium channels

1 reference

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7 January 2021

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7 January 2021

Global mapping of pharmacological space

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7 January 2021

Identifiers

DOI

10.1002/CMDC.200700026

2 references

Consolidated OpenCitations Corpus – April 2017

889051

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17477341%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

889051

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

2 references

889051