(Q83710108)

English

Sustained expression of circulating human alpha-1 antitrypsin reduces inflammation, increases CD4+FoxP3+ Treg cell population and prevents signs of experimental autoimmune encephalomyelitis in mice

scientific article published on 25 March 2011

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scholarly article

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Europe PubMed Central

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26 January 2020

Sustained expression of circulating human alpha-1 antitrypsin reduces inflammation, increases CD4+FoxP3+ Treg cell population and prevents signs of experimental autoimmune encephalomyelitis in mice (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21437674%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

experimental autoimmune encephalomyelitis

1 reference

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7

object named as

Halina Offner

1 reference

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26 January 2020

author name string

Sandhya Subramanian

1

1 reference

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26 January 2020

Galit Shahaf

2

1 reference

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26 January 2020

Eyal Ozeri

3

1 reference

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26 January 2020

Lisa M Miller

4

1 reference

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26 January 2020

Arthur A Vandenbark

5

1 reference

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26 January 2020

Eli C Lewis

6

1 reference

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26 January 2020

publication date

25 March 2011

1 reference

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26 January 2020

Metabolic Brain Disease

1 reference

Europe PubMed Central

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26 January 2020

26

1 reference

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26 January 2020

2

1 reference

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26 January 2020

107-113

1 reference

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26 January 2020

https://scigraph.springernature.com/pub.10.1007/s11011-011-9239-9

0 references

Serum alpha 1-protease inhibitor in diabetes mellitus: reduced concentration and impaired activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

alpha1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exacerbation of type II collagen-induced arthritis in apolipoprotein E-deficient mice in association with the expansion of Th1 and Th17 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CCR6 regulates EAE pathogenesis by controlling regulatory CD4+ T-cell recruitment to target tissues.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired activity of serum alpha-1-antitrypsin in diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha1-antitrypsin monotherapy prolongs islet allograft survival in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Virtues and pitfalls of EAE for the development of therapies for multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IgA-alpha-1-antitrypsin complex in systemic lupus erythematosus: preliminary report

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term augmentation therapy with alpha-1 antitrypsin in an MZ-AAT severe persistent asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic efficacy of α-1 antitrypsin augmentation therapy on the loss of lung tissue: an integrated analysis of 2 randomised clinical trials using computed tomography densitometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes of neutrophil elastase and alpha 1-antitrypsin in systemic lupus erythematosus

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

α-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The prevalence and clinical significance of alpha 1-antitrypsin deficiency (PiZ) and ANCA specificities (proteinase 3, BPI) in patients with ulcerative colitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha1-antitrypsin protects beta-cells from apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between α1-antitrypsin inactivation and tumor necrosis factor α concentration in the synovial fluid of patients with rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T-cell-specific deletion of STIM1 and STIM2 protects mice from EAE by impairing the effector functions of Th1 and Th17 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-1-antitrypsin is an endogenous inhibitor of proinflammatory cytokine production in whole blood

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Th17/Treg imbalance and cytokine environment in peripheral blood of patients with rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systemic inflammation in chronic obstructive pulmonary disease and asthma: Similarities and differences

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cutting edge: estrogen drives expansion of the CD4+CD25+ regulatory T cell compartment

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Docosahexaenoic acid prevents dendritic cell maturation, inhibits antigen-specific Th1/Th17 differentiation and suppresses experimental autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pulmonary epithelial expression of human alpha1-antitrypsin in transgenic mice results in delivery of alpha1-antitrypsin protein to the interstitium

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CCR6 marks regulatory T cells as a colon-tropic, IL-10-producing phenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amelioration of experimental autoimmune encephalomyelitis by β-elemene treatment is associated with Th17 and Treg cell balance

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Th17 central memory T cells are reduced by FTY720 in patients with multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

alpha1-Antitrypsin deficiency, chronic obstructive pulmonary disease and the serpinopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

α 1-antitrypsin enhances insulin secretion and prevents cytokine-mediated apoptosis in pancreatic β-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute cigarette smoke-induced connective tissue breakdown is mediated by neutrophils and prevented by alpha1-antitrypsin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor delta agonists inhibit T helper type 1 (Th1) and Th17 responses in experimental allergic encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CCR6 regulates the migration of inflammatory and regulatory T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased IL-17 production by peripheral T helper cells after tumour necrosis factor blockade in rheumatoid arthritis is accompanied by inhibition of migration-associated chemokine receptor expression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

alpha1-Antitrypsin regulates CD14 expression and soluble CD14 levels in human monocytes in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiinflammatory properties of hepatic acute phase proteins: preferential induction of interleukin 1 (IL-1) receptor antagonist over IL-1 beta synthesis by human peripheral blood mononuclear cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complex extra-intestinal complications of ulcerative colitis in a patient with alpha1-antitrypsin deficiency.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha1-antitrypsin deficiency and inflammatory bowel diseases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alteration of plasma proteinase-antiproteinase system in type 1 diabetic patients. Influence of sex and relationship with metabolic control

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IDO upregulates regulatory T cells via tryptophan catabolite and suppresses encephalitogenic T cell responses in experimental autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of proteinase 3 by [alpha]1-antitrypsin in vitro predicts very fast inhibition in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The IL-17 pathway as a major therapeutic target in autoimmune diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum protease inhibitor concentrations and total antitrypsin activity in diabetic and non-diabetic children during adolescence.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combination of alpha-1 antitrypsin and doxycycline suppresses collagen-induced arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aerosolized prolastin suppresses bacterial proliferation in a model of chronic Pseudomonas aeruginosa lung infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NLRP3 plays a critical role in the development of experimental autoimmune encephalomyelitis by mediating Th1 and Th17 responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New Findings in PiZZ alpha1-antitrypsin deficiency-related panniculitis. Demonstration of skin polymers and high dosing requirements of intravenous augmentation therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum trypsin inhibitory capacity in normal pregnancy and gestational diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

alpha1-Antitrypsin inhibits the lethal response to TNF in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-1 regulates the inflammatory process leading to autoimmune demyelination

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intradermal alpha1-antitrypsin therapy avoids fatal anaphylaxis, prevents type 1 diabetes and reverses hyperglycaemia in the NOD mouse model of the disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21437674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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