(Q83948736)

English

Partial rescue of in vivo insulin signalling in skeletal muscle by impaired insulin clearance in heterozygous carriers of a mutation in the insulin receptor gene

scientific article published on 08 June 2006

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16761106%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

Partial rescue of in vivo insulin signalling in skeletal muscle by impaired insulin clearance in heterozygous carriers of a mutation in the insulin receptor gene (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16761106%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

1 reference

based on heuristic

inferred from title

Jørgen Wojtaszewski

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16761106%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16761106%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

Henrik Vestergaard

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16761106%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

author name string

K Højlund

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16761106%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

B F Hansen

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16761106%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

H Beck-Nielsen

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16761106%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

publication date

8 June 2006

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16761106%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16761106%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

49

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16761106%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

8

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16761106%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

1827-1837

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16761106%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

https://scigraph.springernature.com/pub.10.1007/s00125-006-0312-6

0 references

Down-regulation of cell surface insulin receptor and insulin receptor substrate-1 phosphorylation by inhibitor of 90-kDa heat-shock protein family: endoplasmic reticulum retention of monomeric insulin receptor precursor with calnexin in adrenal chro

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of Akt kinase activity by binding to Hsp90

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of genetic versus environmental factors on the control of muscle glycogen synthase activation in twins

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lilly Lecture: molecular mechanisms of insulin resistance. Lessons from patients with mutations in the insulin-receptor gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced glycogen synthase activity in skeletal muscle from obese patients with and without type 2 (non-insulin-dependent) diabetes mellitus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of insulin/IGF-I hybrid receptors is increased in skeletal muscle of patients with chronic primary hyperinsulinemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteome analysis reveals phosphorylation of ATP synthase beta -subunit in human skeletal muscle and proteins with potential roles in type 2 diabetes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased phosphorylation of skeletal muscle glycogen synthase at NH2-terminal sites during physiological hyperinsulinemia in type 2 diabetes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevalence of mutations in the insulin receptor gene in subjects with features of the type A syndrome of insulin resistance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergistic activation of endothelial nitric-oxide synthase (eNOS) by HSP90 and Akt: calcium-independent eNOS activation involves formation of an HSP90-Akt-CaM-bound eNOS complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cultured muscle cells from insulin-resistant type 2 diabetes patients have impaired insulin, but normal 5-amino-4-imidazolecarboxamide riboside-stimulated, glucose uptake

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of heat shock protein 90 in the degradation of mutant insulin receptors by the proteasome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased expression of insulin/insulin-like growth factor-I hybrid receptors in skeletal muscle of noninsulin-dependent diabetes mellitus subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycogen synthase and phosphofructokinase protein and mRNA levels in skeletal muscle from insulin-resistant patients with non-insulin-dependent diabetes mellitus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ceramide content is increased in skeletal muscle from obese insulin-resistant humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New insights into the role and mechanism of glycogen synthase activation by insulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reference intervals for glucose, beta-cell polypeptides, and counterregulatory factors during prolonged fasting

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of exercise on insulin action in human skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PDK1, one of the missing links in insulin signal transduction?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel syndrome of autosomal-dominant hyperinsulinemic hypoglycemia linked to a mutation in the human insulin receptor gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Naturally occurring amino acid substitutions at Arg1174 in the human insulin receptor result in differential effects on receptor biosynthesis and hybrid formation, leading to discordant clinical phenotypes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional properties of a heterozygous mutation (Arg1174-->Gln) in the tyrosine kinase domain of the insulin receptor from a type A insulin resistant patient

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two naturally occurring mutant insulin receptors phosphorylate insulin receptor substrate-1 (IRS-1) but fail to mediate the biological effects of insulin. Evidence that IRS-1 phosphorylation is not sufficient for normal insulin action

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin receptor knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 is defective in muscle in type 2 diabetes and impaired glucose tolerance: amelioration by rosiglitazone and exercise

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The primary defect in glycogen synthase activity is not based on increased glycogen synthase kinase-3alpha activity in diabetic myotubes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Implications of compound heterozygous insulin receptor mutations in congenital muscle fibre type disproportion myopathy for the receptor kinase activation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin signaling in human skeletal muscle: time course and effect of exercise

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin resistance of glycogen synthase mediated by o-linked N-acetylglucosamine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular glucose oxidation and glycogen synthase activity are reduced in non-insulin-dependent (type II) diabetes independent of impaired glucose uptake

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two Naturally Occurring Insulin Receptor Tyrosine Kinase Domain Mutants Provide Evidence That Phosphoinositide 3-Kinase Activation Alone Is Not Sufficient for the Mediation of Insulin’s Metabolic and Mitogenic Effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16761106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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