(Q84120968)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20424620%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

review article

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title

Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker's yeast? (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20424620%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

main subject

Saccharomyces cerevisiae

object named as

Saccharomyces cerevisiae

1 reference

1 reference

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20424620%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

2

Susan Lindquist

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20424620%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

publication date

28 April 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20424620%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Neuroscience

1 February 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20424620%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

volume

11

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20424620%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

issue

6

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20424620%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

page(s)

436-449

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20424620%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nrn2809

1 February 2020

exact match

0 references

cites work

Yeast as a model for human disease

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alpha-Synuclein fission yeast model: concentration-dependent aggregation without plasma membrane localization or toxicity

31 March 2020

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S. pombe btn1, the orthologue of the Batten disease gene CLN3, is required for vacuole protein sorting of Cpy1p and Golgi exit of Vps10p

31 March 2020

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Yeast as a model organism

31 March 2020

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Yeast genes and human disease

31 March 2020

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Human genetic diseases: a cross-talk between man and yeast

31 March 2020

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Investigating protein conformation-based inheritance and disease in yeast

31 March 2020

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Unraveling infectious structures, strain variants and species barriers for the yeast prion [PSI+].

31 March 2020

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Mitochondrial fragmentation in neurodegeneration

31 March 2020

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Rothman and Schekman SNAREd by Lasker for trafficking

31 March 2020

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Synaptotagmin controls and modulates synaptic-vesicle fusion in a Ca(2+)-dependent manner

31 March 2020

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Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

31 March 2020

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Endoplasmic reticulum stress in disorders of myelinating cells.

31 March 2020

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Endoplasmic reticulum protein quality control in neurodegenerative disease: the good, the bad and the therapy

31 March 2020

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Cell cycle regulation in the postmitotic neuron: oxymoron or new biology?

31 March 2020

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31 March 2020

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Mitochondrial death pathways in yeast and mammalian cells

31 March 2020

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The pleiotropic effects of heterologous Bax expression in yeast.

31 March 2020

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Dynamics and diversity in autophagy mechanisms: lessons from yeast

31 March 2020

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Autophagy in the Pathogenesis of Disease

31 March 2020

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Yeast: an experimental organism for modern biology

31 March 2020

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Getting started with yeast

31 March 2020

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Endoplasmic reticulum stress and the making of a professional secretory cell

31 March 2020

1 reference

The yeast connection to Friedreich ataxia.

31 March 2020

1 reference

Trinucleotide Repeat Disorders

31 March 2020

1 reference

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

31 March 2020

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Altered transcription in yeast expressing expanded polyglutamine

31 March 2020

1 reference

Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins

31 March 2020

1 reference

Huntington toxicity in yeast model depends on polyglutamine aggregation mediated by a prion-like protein Rnq1

31 March 2020

1 reference

Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

31 March 2020

1 reference

A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease

31 March 2020

1 reference

Expression of an expanded polyglutamine domain in yeast causes death with apoptotic markers

31 March 2020

1 reference

Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity

31 March 2020

1 reference

Alpha-synuclein alters proteasome function, protein synthesis, and stationary phase viability.

31 March 2020

1 reference

Alpha-synuclein targets the plasma membrane via the secretory pathway and induces toxicity in yeast

31 March 2020

1 reference

Heat shock prevents alpha-synuclein-induced apoptosis in a yeast model of Parkinson's disease

31 March 2020

1 reference

Yeast cells provide insight into alpha-synuclein biology and pathobiology

31 March 2020

1 reference

alpha-Synuclein budding yeast model: toxicity enhanced by impaired proteasome and oxidative stress

31 March 2020

1 reference

Protein folding diseases and neurodegeneration: lessons learned from yeast

31 March 2020

1 reference

Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models

31 March 2020

1 reference

Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models

31 March 2020

1 reference

A small-molecule therapeutic lead for Huntington's disease: preclinical pharmacology and efficacy of C2-8 in the R6/2 transgenic mouse

31 March 2020

1 reference

Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation

31 March 2020

1 reference

A network of protein interactions determines polyglutamine toxicity

31 March 2020

1 reference

Flanking sequences profoundly alter polyglutamine toxicity in yeast

31 March 2020

1 reference

Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

31 March 2020

1 reference

Searching for a relationship between manganese and welding and Parkinson's disease

31 March 2020

1 reference

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

31 March 2020

1 reference

Cd2+, Mn2+, Ni2+ and Se2+ toxicity to Saccharomyces cerevisiae lacking YPK9p the orthologue of human ATP13A2

31 March 2020

1 reference

Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity

31 March 2020

1 reference

Statin use and the risk of Parkinson disease

31 March 2020

1 reference

A systematic library for comprehensive overexpression screens in Saccharomyces cerevisiae

31 March 2020

1 reference

Exploring the metabolic and genetic control of gene expression on a genomic scale

31 March 2020

1 reference

A suite of Gateway cloning vectors for high-throughput genetic analysis in Saccharomyces cerevisiae

31 March 2020

1 reference

Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry

31 March 2020

1 reference

The emergence of yeast lipidomics

31 March 2020

1 reference

Yeast chemical genomics and drug discovery: an update

31 March 2020

1 reference

Exploring the Mode-of-Action of Bioactive Compounds by Chemical-Genetic Profiling in Yeast

31 March 2020

1 reference

The chemical genomic portrait of yeast: uncovering a phenotype for all genes

31 March 2020

1 reference

Yeast as a drug discovery platform in Huntington's and Parkinson's diseases

31 March 2020

1 reference

Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein

31 March 2020

1 reference

A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo

31 March 2020

1 reference

Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models

31 March 2020

1 reference

Drosophila in the study of neurodegenerative disease

31 March 2020

1 reference

The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions

31 March 2020

1 reference

Overexpression of yeast hsp104 reduces polyglutamine aggregation and prolongs survival of a transgenic mouse model of Huntington's disease

31 March 2020

1 reference

Rrs1 is involved in endoplasmic reticulum stress response in Huntington disease

31 March 2020

1 reference

Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disorders

31 March 2020

1 reference

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

31 March 2020

1 reference

Amyloid deposits: protection against toxic protein species?

31 March 2020

1 reference

The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis

31 March 2020

1 reference

Alpha-synuclein-induced aggregation of cytoplasmic vesicles in Saccharomyces cerevisiae

31 March 2020

1 reference

YGR198w (YPP1) targets A30P alpha-synuclein to the vacuole for degradation

31 March 2020

1 reference

A yeast-based model of alpha-synucleinopathy identifies compounds with therapeutic potential

31 March 2020

1 reference

Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis

31 March 2020

1 reference

Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis

31 March 2020

1 reference

Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein

31 March 2020

1 reference

Action of BTN1, the yeast orthologue of the gene mutated in Batten disease

31 March 2020

1 reference

Ncr1p, the yeast ortholog of mammalian Niemann Pick C1 protein, is dispensable for endocytic transport

31 March 2020

1 reference

Neurodegeneration mutations in dynactin impair dynein-dependent nuclear migration.

31 March 2020

1 reference

Hereditary spastic paraplegia: mitochondrial metalloproteases of yeast

31 March 2020

1 reference

A Saccharomyces cerevisiae homolog of the human adrenoleukodystrophy transporter is a heterodimer of two half ATP-binding cassette transporters

31 March 2020

1 reference

Searching for the most effective screening system to identify cell-active inhibitors of beta-secretase

31 March 2020

1 reference

Modulation of Abeta42 low-n oligomerization using a novel yeast reporter system

31 March 2020

1 reference

Development of a novel yeast cell-based system for studying the aggregation of Alzheimer's disease-associated Abeta peptides in vivo.

31 March 2020

1 reference

Alzheimer's Abeta fused to green fluorescent protein induces growth stress and a heat shock response.

31 March 2020

1 reference

A new method to measure cellular toxicity of non-fibrillar and fibrillar Alzheimer's Abeta using yeast.

31 March 2020

1 reference

A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity

31 March 2020

1 reference

Cellular tolerance of prion protein PrP in yeast involves proteolysis and the unfolded protein response

31 March 2020

1 reference

De novo generation of a PrPSc-like conformation in living cells.

31 March 2020

1 reference

Prion protein repeat expansion results in increased aggregation and reveals phenotypic variability.

31 March 2020

1 reference