(Q84232214)

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HMG-CoA reductase inhibitor simvastatin suppresses Toll-like receptor 2 ligand-induced activation of nuclear factor kappa B by preventing RhoA activation in monocytes from rheumatoid arthritis patients

scientific article published on 15 May 2010

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20473500%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

HMG-CoA reductase inhibitor simvastatin suppresses Toll-like receptor 2 ligand-induced activation of nuclear factor kappa B by preventing RhoA activation in monocytes from rheumatoid arthritis patients (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20473500%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

rheumatoid arthritis

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Haobo Lin

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20473500%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

Youjun Xiao

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20473500%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

Guoqiang Chen

3

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20473500%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

Di Fu

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20473500%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

Yujin Ye

5

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Europe PubMed Central

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2 February 2020

Liuqin Liang

6

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20473500%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

Jinjin Fan

7

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20473500%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

Xiuyan Yang

8

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20473500%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

Lin Sun

9

1 reference

Europe PubMed Central

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2 February 2020

Hanshi Xu

10

1 reference

Europe PubMed Central

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2 February 2020

publication date

15 May 2010

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20473500%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

Rheumatology International

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20473500%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

31

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Europe PubMed Central

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2 February 2020

11

1 reference

Europe PubMed Central

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2 February 2020

1451-1458

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20473500%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

Regulation of the mevalonate pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel anti-inflammatory role for simvastatin in inflammatory arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rho and Rac take center stage

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mononuclear phagocytes and rheumatoid synovitis. Mastermind or workhorse in arthritis?

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-malarial agent artesunate inhibits TNF-alpha-induced production of proinflammatory cytokines via inhibition of NF-kappaB and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AP-1 and NF-kappaB regulation in rheumatoid arthritis and murine collagen-induced arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essential role of T cell NF-kappa B activation in collagen-induced arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trial of Atorvastatin in Rheumatoid Arthritis (TARA): double-blind, randomised placebo-controlled trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rho GTPases and signaling networks

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of Toll-like receptor signalling in the pathogenesis of arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of a sensitive multi-well colorimetric assay for active NFkappaB

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of Toll-like receptor 2 on CD16+ blood monocytes and synovial tissue macrophages in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macrophages and their products in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis of rheumatoid synovial cells by statins through the blocking of protein geranylgeranylation: a potential therapeutic approach to rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein lipidation in cell signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NF-kappaB activation provides the potential link between inflammation and hyperplasia in the arthritic joint

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small GTP-binding protein Rho-mediated signaling promotes proliferation of rheumatoid synovial fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cutting edge: induced expression of a RhoA-specific guanine nucleotide exchange factor, p190RhoGEF, following CD40 stimulation and WEHI 231 B cell activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-inflammatory and immunomodulatory effects of statins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced "inside-out" signaling to extracellular matrix by preventing RhoA activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RhoA-mediated, tumor necrosis factor alpha-induced activation of NF-kappaB in rheumatoid synoviocytes: inhibitory effect of simvastatin

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signaling from Ras to Rac and beyond: not just a matter of GEFs

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The toll-like receptor-nuclear factor kappaB pathway in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Statins decrease Toll-like receptor 4 expression and downstream signaling in human CD14+ monocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LPS induction of gene expression in human monocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/ p21 signaling pathway: Implications for diabetic nephropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-inflammatory and analgesic effects of atorvastatin in a rat model of adjuvant-induced arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation, immunity, and HMG-CoA reductase inhibitors: statins as antiinflammatory agents?

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The low molecular weight GTPase RhoA and atypical protein kinase Czeta are required for TLR2-mediated gene transcription

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapy with statins in patients with refractory rheumatic diseases: a preliminary study

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T lymphocytes as targets of statins: molecular mechanisms and therapeutic perspectives

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitor of nuclear factor kappaB kinase beta is a key regulator of synovial inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RhoA GTPase activation by TLR2 and TLR3 ligands: connecting via Src to NF-kappa B

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rho signals to cell growth and apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear factor-kappa B in rheumatoid synovium. Localization of p50 and p65

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal transduction networks in rheumatoid arthritis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased macrophage activation mediated through toll-like receptors in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simvastatin modulates angiotensin II signaling pathway by preventing Rac1-mediated upregulation of p27.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of Angiotensin-converting enzyme inhibition and statin treatment on inflammatory markers and endothelial functions in patients with longterm rheumatoid arthritis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20473500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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