(Q84938053)

English

Structure-guided design of an invariant natural killer T cell agonist for optimum protection from type 1 diabetes in non-obese diabetic mice

scientific article published on 01 October 2011

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scholarly article

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12 February 2020

Structure-guided design of an invariant natural killer T cell agonist for optimum protection from type 1 diabetes in non-obese diabetic mice (English)

1 reference

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12 February 2020

author name string

H J Blumenfeld

1

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12 February 2020

R Tohn

2

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12 February 2020

S M M Haeryfar

3

1 reference

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12 February 2020

Y Liu

4

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12 February 2020

P B Savage

5

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12 February 2020

T L Delovitch

6

1 reference

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12 February 2020

publication date

1 October 2011

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12 February 2020

Clinical and Experimental Immunology

1 reference

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12 February 2020

166

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12 February 2020

1

1 reference

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12 February 2020

121-133

1 reference

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12 February 2020

Invariant natural killer T cells: innate-like T cells with potent immunomodulatory activities

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of Th17 cells regulates autoimmune diabetes in NOD mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Linking inflammation to natural killer T cell activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The roles of 3' and 4' hydroxy groups in alpha-galactosylceramide stimulation of invariant natural killer T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Invariant NKT cells preferentially modulate the function of CD8 alpha+ dendritic cell subset in inducing type 1 immunity against infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD169(+) macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthetic iNKT cell-agonists as vaccine adjuvants--finding the balance

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immune cell crosstalk in type 1 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An alpha-galactosylceramide C20:2 N-acyl variant enhances anti-inflammatory and regulatory T cell-independent responses that prevent type 1 diabetes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design of a potent CD1d-binding NKT cell ligand as a vaccine adjuvant

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subcutaneous insulin B:9-23/IFA immunisation induces Tregs that control late-stage prediabetes in NOD mice through IL-10 and IFNgamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Natural killer cells from children with type 1 diabetes have defects in NKG2D-dependent function and signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of a shorter duration in the state of anergy by an invariant natural killer T cell agonist enhances its efficiency of protection from type 1 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NKT cell exacerbation of liver metastases arising from melanomas transplanted into either the eyes or spleens of mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of decidual Valpha14 NKT cells in abortion

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of hepatic NKT cells and subsequent liver injury following administration of α-galactosylceramide

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Circulating V(alpha24+) Vbeta11+ NKT cell numbers are decreased in a wide variety of diseases that are characterized by autoreactive tissue damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD1-restricted NK T cells protect nonobese diabetic mice from developing diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The natural killer T-cell ligand α-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of natural killer T cells by alpha-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Testing the NKT cell hypothesis of human IDDM pathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human peripheral blood Valpha24+ Vbeta11+ NKT cells expand following administration of alpha-galactosylceramide-pulsed dendritic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Janus-like role of regulatory iNKT cells in autoimmune disease and tumour immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The NKT cell system: bridging innate and acquired immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Superior protection against malaria and melanoma metastases by a C-glycoside analogue of the natural killer T cell ligand alpha-Galactosylceramide

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic activation of Vα24+Vβ11+ NKT cells in human subjects results in highly coordinated secondary activation of acquired and innate immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD1d-dependent activation of NKT cells aggravates atherosclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Natural killer T cells contribute to airway eosinophilic inflammation induced by ragweed through enhanced IL-4 and eotaxin production

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-4 but not interleukin-10 protects against spontaneous and recurrent type 1 diabetes by activated CD1d-restricted invariant natural killer T-cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of lipid chain lengths in alpha-galactosylceramides on cytokine release by natural killer T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective reduction of V alpha 14+ NK T cells associated with disease development in autoimmune-prone mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early quantitative and functional deficiency of NK1+-like thymocytes in the NOD mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthetic glycolipid OCH prevents insulitis and diabetes in NOD mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

alpha-Galactosylceramide therapy for autoimmune diseases: prospects and obstacles

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activated NKT cells inhibit autoimmune diabetes through tolerogenic recruitment of dendritic cells to pancreatic lymph nodes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of CD1d-restricted NKT cell responses by using N-acyl variants of alpha-galactosylceramides

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recognition of bacterial glycosphingolipids by natural killer T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sustained expansion of NKT cells and antigen-specific T cells after injection of alpha-galactosyl-ceramide loaded mature dendritic cells in cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The crystal structure of human CD1d with and without alpha-galactosylceramide

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycolipid antigen induces long-term natural killer T cell anergy in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design of natural killer T cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1d

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improved outcomes in NOD mice treated with a novel Th2 cytokine-biasing NKT cell activator

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The biology of NKT cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PD-1 and PD-1 ligands: from discovery to clinical application

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The countervailing actions of myeloid and plasmacytoid dendritic cells control autoimmune diabetes in the nonobese diabetic mouse.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PD-1 and its ligands in tolerance and immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ligand-dependent induction of noninflammatory dendritic cells by anergic invariant NKT cells minimizes autoimmune inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phase I-II study of alpha-galactosylceramide-pulsed IL-2/GM-CSF-cultured peripheral blood mononuclear cells in patients with advanced and recurrent non-small cell lung cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PD-1/PD-L blockade prevents anergy induction and enhances the anti-tumor activities of glycolipid-activated invariant NKT cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NKT cell-plasmacytoid dendritic cell cooperation via OX40 controls viral infection in a tissue-specific manner.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Natural lipid ligands associated with human CD1d targeted to different subcellular compartments

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recognition of lyso-phospholipids by human natural killer T lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21910729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1365-2249.2011.04454.X

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21910729%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

0 references

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21910729%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

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