(Q85029032)

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Delayed administration of parecoxib, a specific COX-2 inhibitor, attenuated postischemic neuronal apoptosis by phosphorylation Akt and GSK-3β

scientific article published on 30 September 2011

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21964800%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Delayed administration of parecoxib, a specific COX-2 inhibitor, attenuated postischemic neuronal apoptosis by phosphorylation Akt and GSK-3β (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21964800%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

author name string

Zhi Ye

1

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13 February 2020

Na Wang

2

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13 February 2020

Pingping Xia

3

1 reference

Europe PubMed Central

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13 February 2020

E Wang

4

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Europe PubMed Central

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13 February 2020

Yajing Yuan

5

1 reference

Europe PubMed Central

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13 February 2020

Qulian Guo

6

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13 February 2020

publication date

30 September 2011

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Europe PubMed Central

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13 February 2020

Neurochemical Research

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21964800%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

37

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Europe PubMed Central

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13 February 2020

2

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Europe PubMed Central

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13 February 2020

321-329

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21964800%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Misoprostol, an anti-ulcer agent and PGE2 receptor agonist, protects against cerebral ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of the relative contribution of COX-1 and COX-2 isoforms to ischemia-induced oxidative damage and neurodegeneration following transient global cerebral ischemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of cyclooxygenase-2 mRNA in gerbil hippocampal neurons after transient forebrain ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycogen synthase kinase 3: a key regulator of cellular fate.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Middle cerebral artery occlusion in the rat by intraluminal suture. Neurological and pathological evaluation of an improved model

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Programmed cell death in cerebral ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased neuronal injury in transgenic mice with neuronal overexpression of human cyclooxygenase-2 is reversed by hypothermia and rofecoxib treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of Akt/GSK-3beta signaling pathway is involved in intermedin(1-53) protection against myocardial apoptosis induced by ischemia/reperfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Excitotoxic mechanisms in stroke: an update of concepts and treatment strategies

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parecoxib inhibits apoptosis in acute myocardial infarction due to permanent coronary ligation but not due to ischemia-reperfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Urinary tract obstruction induces transient accumulation of COX-2-derived prostanoids in kidney tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostaglandin E2 EP1 receptors: downstream effectors of COX-2 neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal overexpression of cyclooxygenase-2 increases cerebral infarction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclooxygenase inhibition in ischemic brain injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation in stroke: the good, the bad, and the unknown

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The inflammatory response in stroke

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A unified model for apical caspase activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IGF-I neuroprotection in the immature brain after hypoxia-ischemia, involvement of Akt and GSK3beta?

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression and cellular localization of cyclooxygenases and prostaglandin E synthases in the hemorrhagic brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of phosphoinositide-3-kinase/Akt pathway in propofol-induced postconditioning against focal cerebral ischemia-reperfusion injury in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estradiol protects against oxygen and glucose deprivation in rat hippocampal organotypic cultures and activates Akt and inactivates GSK-3beta.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence of phosphorylation of Akt and neuronal survival after transient focal cerebral ischemia in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isoflurane preconditioning increases B-cell lymphoma-2 expression and reduces cytochrome c release from the mitochondria in the ischemic penumbra of rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PI3K inhibition in neonatal rat brain slices during and after hypoxia reduces phospho-Akt and increases cytosolic cytochrome c and apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Celecoxib induces functional recovery after intracerebral hemorrhage with reduction of brain edema and perihematomal cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure, regulation and function of PKB/AKT--a major therapeutic target

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Post-ischemic inflammation: molecular mechanisms and therapeutic implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt contributes to neuroprotection by hypothermia against cerebral ischemia in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Central nervous system concentrations of cyclooxygenase-2 inhibitors in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiological and pathological changes in glucose regulate brain Akt and glycogen synthase kinase-3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nimesulide as a promising neuroprotectant in brain ischemia: new experimental evidences

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of genetic deficiency of cyclooxygenase-1 or cyclooxygenase-2 on functional and histological outcomes following traumatic brain injury in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improvement of cardiac function with parecoxib, a cyclo-oxygenase-2 inhibitor, in a rat model of ischemic heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parecoxib is neuroprotective in spontaneously hypertensive rats after transient middle cerebral artery occlusion: a divided treatment response?

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclooxygenase-2-specific inhibitor improves functional outcomes, provides neuroprotection, and reduces inflammation in a rat model of traumatic brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: their role and involvement in neurological disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of COX-2 inhibitor meloxicam against traumatic brain injury-induced biochemical, histopathological changes and blood-brain barrier permeability

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

alpha-Amino-3-hydroxy-5-methyl-4-isoxazole propionate attenuates glutamate-induced caspase-3 cleavage via regulation of glycogen synthase kinase 3beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Volatile anesthetic preconditioning attenuates myocardial apoptosis in rabbits after regional ischemia and reperfusion via Akt signaling and modulation of Bcl-2 family proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of cycloxygenase-2 in the rodent kidney following ischaemia/reperfusion injury in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Delayed effect of administration of COX-2 inhibitor in mice with acute cerebral ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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