(Q34806489)

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Cyclooxygenase-2-specific inhibitor improves functional outcomes, provides neuroprotection, and reduces inflammation in a rat model of traumatic brain injury

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Europe PubMed Central

PubMed publication ID

4 August 2017

Cyclooxygenase-2-specific inhibitor improves functional outcomes, provides neuroprotection, and reduces inflammation in a rat model of traumatic brain injury (English)

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

traumatic brain injury

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author name string

Jonas J Gopez

1

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Hongfei Yue

2

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Ram Vasudevan

3

1 reference

Europe PubMed Central

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4 August 2017

Amir S Malik

4

1 reference

Europe PubMed Central

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4 August 2017

Lester N Fogelsanger

5

1 reference

Europe PubMed Central

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4 August 2017

Shawn Lewis

6

1 reference

Europe PubMed Central

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4 August 2017

David Panikashvili

7

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Esther Shohami

8

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Susan A Jansen

9

1 reference

Europe PubMed Central

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4 August 2017

Raj K Narayan

10

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Europe PubMed Central

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4 August 2017

Kenneth I Strauss

11

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4 August 2017

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publication date

1 March 2005

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Europe PubMed Central

PubMed publication ID

4 August 2017

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Europe PubMed Central

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4 August 2017

56

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Europe PubMed Central

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4 August 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

590-604

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Effect of intravenous corticosteroids on death within 14 days in 10008 adults with clinically significant head injury (MRC CRASH trial): randomised placebo-controlled trial

1 reference

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8 July 2018

A novel dehydroepiandrosterone analog improves functional recovery in a rat traumatic brain injury model.

1 reference

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8 July 2018

Regulation of cyclooxygenase-2 expression by iloprost in human vascular smooth muscle cells. Role of transcription factors CREB and ICER.

1 reference

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8 July 2018

Cyclooxygenase-2 inhibition protects cultured cerebellar granule neurons from glutamate-mediated cell death

1 reference

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8 July 2018

Clinical trials in head injury

1 reference

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8 July 2018

Cyclooxygenase inhibition as a strategy to ameliorate brain injury.

1 reference

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8 July 2018

An endogenous cannabinoid (2-AG) is neuroprotective after brain injury

1 reference

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8 July 2018

The selective cyclooxygenase-2 inhibitor rofecoxib reduces kainate-induced cell death in the rat hippocampus

1 reference

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8 July 2018

Anti-inflammatory effects of prostaglandin E2 in the central nervous system in response to brain injury and circulating lipopolysaccharide

1 reference

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8 July 2018

Prolonged cyclooxygenase-2 induction in neurons and glia following traumatic brain injury in the rat.

1 reference

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8 July 2018

Oxygenation of the endocannabinoid, 2-arachidonylglycerol, to glyceryl prostaglandins by cyclooxygenase-2.

1 reference

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8 July 2018

Prostaglandin E(2) upregulates cyclooxygenase-2 expression in lipopolysaccharide-stimulated RAW 264.7 macrophages

1 reference

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8 July 2018

Potentiation of excitotoxicity in transgenic mice overexpressing neuronal cyclooxygenase-2

1 reference

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8 July 2018

Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids.

1 reference

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8 July 2018

Differential acute and chronic responses of tumor necrosis factor-deficient mice to experimental brain injury

1 reference

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8 July 2018

Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles

1 reference

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8 July 2018

Why have recent trials of neuroprotective agents in head injury failed to show convincing efficacy? A pragmatic analysis and theoretical considerations

1 reference

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8 July 2018

Cyclooxygenase-2: molecular biology, pharmacology, and neurobiology

1 reference

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8 July 2018

Suppression of inducible cyclooxygenase 2 gene transcription by aspirin and sodium salicylate

1 reference

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8 July 2018

Role of cyclooxygenase 2 in acute spinal cord injury

1 reference

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8 July 2018

Cyclooxygenase-2 inhibition prevents delayed death of CA1 hippocampal neurons following global ischemia

1 reference

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8 July 2018

Increase in surface expression of ICAM-1, VCAM-1 and E-selectin in human cerebromicrovascular endothelial cells subjected to ischemia-like insults

1 reference

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8 July 2018

Differential intracellular sorting of immediate early gene mRNAs depends on signals in the mRNA sequence.

1 reference

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8 July 2018

Corticosteroids in acute traumatic brain injury: systematic review of randomised controlled trials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

8 July 2018

Whole body metabolic responses to brain trauma in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

8 July 2018

A selective inhibitor of cyclooxygenase-2 reverses endotoxin-induced pyretic responses in non-human primates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

8 July 2018

5-HPETE is a potent inhibitor of neuronal Na+, K(+)-ATPase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

8 July 2018

Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor

1 reference

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8 July 2018

Long-term elevation of cyclooxygenase-2, but not lipoxygenase, in regions synaptically distant from spreading depression

1 reference

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8 July 2018

Cyclo-oxygenase-2 messenger RNA induction in focal cerebral ischemia.

1 reference

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8 July 2018

Sustained induction of prostaglandin endoperoxide synthase-2 by seizures in hippocampus. Inhibition by a platelet-activating factor antagonist

1 reference

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8 July 2018

COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

8 July 2018

Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

8 July 2018

Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

8 July 2018

Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: inhibition by nonsteroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

8 July 2018

Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

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Neurochemical sequelae of traumatic brain injury: therapeutic implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

8 July 2018

Involvement of reactive oxygen intermediates in cyclooxygenase-2 expression induced by interleukin-1, tumor necrosis factor-alpha, and lipopolysaccharide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

8 July 2018

Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

8 July 2018

Studies on the induction of cyclooxygenase isozymes by various prostaglandins in mouse osteoblastic cell line with reference to signal transduction pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

8 July 2018

Regional distribution of prostaglandins D2, E2, and F2 alpha and related enzymes in postmortem human brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

8 July 2018

Experimental traumatic brain injury elevates brain prostaglandin E2 and thromboxane B2 levels in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

8 July 2018

Traumatic brain injury in the rat: characterization of a lateral fluid-percussion model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

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Increased plasma PGE2, 6-keto-PGF1 alpha, and 12-HETE levels following experimental concussive brain injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

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Temporal and pharmacological division of fibroblast cyclooxygenase expression into transcriptional and translational phases

1 reference

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8 July 2018

The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes

1 reference

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8 July 2018

A controlled cortical impact model of traumatic brain injury in the rat

1 reference

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8 July 2018

Role of Prostaglandins in Delayed Cerebral Ischemia after Subarachnoid Hemorrhage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

8 July 2018

Glucocorticoids Regulate the Synthesis of Glial Fibrillary Acidic Protein in Intact and Adrenalectomized Rats but Do Not Affect Its Expression Following Brain Injury

1 reference

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8 July 2018

Ischemic brain damage: focus on lipids and lipid mediators

1 reference

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8 July 2018

Cognitive deficits following traumatic brain injury produced by controlled cortical impact

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

8 July 2018

Endogenous glucocorticoids regulate an inducible cyclooxygenase enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

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Isolation and structure of a brain constituent that binds to the cannabinoid receptor

1 reference

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8 July 2018

Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

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Determination of bioactive eicosanoids in brain tissue by a sensitive reversed-phase liquid chromatographic method with fluorescence detection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

26 October 2018

The selective cyclooxygenase-2 inhibitor rofecoxib suppresses brain inflammation and protects cholinergic neurons from excitotoxic degeneration in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

26 October 2018

Inhibition of cyclooxygenase 2 by nimesulide improves cognitive outcome more than motor outcome following diffuse traumatic brain injury in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

26 October 2018

Neuroprotective efficacy of nimesulide against hippocampal neuronal damage following transient forebrain ischemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

26 October 2018

Role of Caspase 3 in neuronal apoptosis after acute brain injury.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

26 October 2018

Upregulation of the Fas receptor death-inducing signaling complex after traumatic brain injury in mice and humans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

26 October 2018

Increased levels of the pro-inflammatory prostaglandin PGE2 in CSF from ALS patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

26 October 2018

The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

26 October 2018

Induction of the complement component C1qB in brain of transgenic mice with neuronal overexpression of human cyclooxygenase-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

26 October 2018

12-hydroxyeicosatetrenoate (12-HETE) attenuates AMPA receptor-mediated neurotoxicity: evidence for a G-protein-coupled HETE receptor.

1 reference

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26 October 2018

Prostaglandin E(2) induces caspase-dependent apoptosis in rat cortical cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

26 October 2018

Caspase-3 activity is present in cerebrospinal fluid from patients with traumatic brain injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

26 October 2018

Accumulation of non-erythroid alpha II-spectrin and calpain-cleaved alpha II-spectrin breakdown products in cerebrospinal fluid after traumatic brain injury in rats.

1 reference

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26 October 2018

Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid 2-arachidonylglycerol

1 reference

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26 October 2018

Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction

1 reference

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26 October 2018

Injury-induced apoptosis of neurons in adult brain is mediated by p53-dependent and p53-independent pathways and requires Bax.

1 reference

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26 October 2018

Regional expression and role of cyclooxygenase-2 following experimental traumatic brain injury.

1 reference

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26 October 2018

Determination and clinical significance of plasma levels of prostaglandins in patients with acute brain injury

1 reference

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26 October 2018

Localization and distribution of cyclooxygenase-2 in brain tissue by immunohistochemistry

1 reference

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26 October 2018

Opioids, NSAIDs and 5-lipoxygenase inhibitors act synergistically in brain via arachidonic acid metabolism

1 reference

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26 October 2018

Arachidonic acid as a messenger for the expression of long-term potentiation

1 reference

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26 October 2018

Inhibition of antagonist and agonist binding to the human brain muscarinic receptor by arachidonic acid.

1 reference

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26 October 2018

Experimental brain injury induces regionally distinct apoptosis during the acute and delayed post-traumatic period.

1 reference

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26 October 2018

Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia.

1 reference

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26 October 2018

Circadian expression of pineal 5-lipoxygenase mRNA.

1 reference

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26 October 2018

The relationship of soluble adhesion molecule concentrations in systemic and jugular venous serum to injury severity and outcome after traumatic brain injury.

1 reference

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26 October 2018

Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

26 October 2018

Regulatory role of prostaglandin E2 in induction of cyclo-oxygenase-2 by a thromboxane A2 analogue (U46619) and basic fibroblast growth factor in porcine aortic smooth-muscle cells

1 reference

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26 October 2018

Evidence for an intramedullary prostaglandin-dependent mechanism in the activation of stress-related neuroendocrine circuitry by intravenous interleukin-1.

1 reference

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26 October 2018

The induction of ICAM-1 in human cerebromicrovascular endothelial cells (HCEC) by ischemia-like conditions promotes enhanced neutrophil/HCEC adhesion.

1 reference

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26 October 2018

Transcranial cytokine gradients in patients requiring intensive care after acute brain injury.

1 reference

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26 October 2018

Maturational regulation and regional induction of cyclooxygenase-2 in rat brain: implications for Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

26 October 2018

Induction of cyclooxygenase-2 following anoxic stress in piglet cerebral arteries.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

26 October 2018

Expression of cyclo-oxygenase 2 in rat brain following kainate treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

26 October 2018

Use of indomethacin in brain-injured patients with cerebral perfusion pressure impairment: preliminary report.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

26 October 2018

Evidence of apoptotic cell death after experimental traumatic brain injury in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

26 October 2018

Cyclooxygenase products of arachidonic acid metabolism in cat cerebral cortex after experimental concussive brain injury.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1513642

26 October 2018

Stretch injury causes calpain and caspase-3 activation and necrotic and apoptotic cell death in septo-hippocampal cell cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/15730585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclooxygenase-2 contributes to N-methyl-D-aspartate-mediated neuronal cell death in primary cortical cell culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/15730585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of fibroblast cyclooxygenase synthesis by interleukin-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/15730585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclooxygenase-2 induction in cerebral cortex: an intracellular response to synaptic excitation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15730585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dexamethasone and Indomethacin Do Not Affect Brain Edema following Head Injury in Rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15730585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

COX-2 and cytosolic PLA2 mediate IL-1beta-induced cAMP production in human vascular smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15730585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A human whole blood assay for clinical evaluation of biochemical efficacy of cyclooxygenase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15730585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15730585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostaglandins suppress an outward potassium current in embryonic rat sensory neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/15730585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Head injury induces increased prostaglandin synthesis in rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/15730585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endocannabinoids

1 reference

https://pubmed.ncbi.nlm.nih.gov/15730585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostaglandin E(2) regulation of cyclooxygenase expression in keratinocytes is mediated via cyclic nucleotide-linked prostaglandin receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15730585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Temporal profile and cell subtype distribution of activated caspase-3 following experimental traumatic brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/15730585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Towards a better aspirin

1 reference

https://pubmed.ncbi.nlm.nih.gov/15730585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1227/01.NEU.0000154060.14900.8F

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

ResearchGate publication ID

0 references

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