(Q85214451)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23076158%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

title

Phospholipase signalling networks in cancer (English)

1 reference

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15 February 2020

9

1 reference

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15 February 2020

8

Pann-Ghill Suh

1 reference

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15 February 2020

4

Jaewang Ghim

1 reference

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15 February 2020

3

Jin-Hyeok Jang

1 reference

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15 February 2020

7

Daehee Hwang

1 reference

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15 February 2020

author name string

Jong Bae Park

1

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15 February 2020

Chang Sup Lee

2

1 reference

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15 February 2020

Youn-Jae Kim

5

1 reference

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15 February 2020

Sungyoung You

6

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15 February 2020

publication date

18 October 2012

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15 February 2020

published in

Nature Reviews Cancer

1 reference

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15 February 2020

volume

12

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15 February 2020

issue

11

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15 February 2020

page(s)

782-792

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https://scigraph.springernature.com/pub.10.1038/nrc3379

15 February 2020

exact match

0 references

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Membrane lipids: where they are and how they behave

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The membrane and lipids as integral participants in signal transduction: lipid signal transduction for the non-lipid biochemist

31 March 2020

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Signal transduction through lipid second messengers

31 March 2020

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Lipid signalling in disease.

31 March 2020

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Phospholipases and their industrial applications.

31 March 2020

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Recent progress on phospholipases: different sources, assay methods, industrial potential and pathogenicity

31 March 2020

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Structure and function of extracellular phospholipase A1 belonging to the pancreatic lipase gene family

31 March 2020

1 reference

Recent progress in phospholipase A₂ research: from cells to animals to humans

31 March 2020

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Signaling functions of phosphatidic acid.

31 March 2020

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Regulatory mechanism and physiological role of cytosolic phospholipase A2

31 March 2020

1 reference

Selective interaction of the C2 domains of phospholipase C-beta1 and -beta2 with activated Galphaq subunits: an alternative function for C2-signaling modules

31 March 2020

1 reference

The pleckstrin homology domain of phospholipase C-beta(2) links the binding of gbetagamma to activation of the catalytic core

31 March 2020

1 reference

Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting.

31 March 2020

1 reference

Phospholipase D regulation and localisation is dependent upon a phosphatidylinositol 4,5-biphosphate-specific PH domain

31 March 2020

1 reference

Hierarchy of membrane-targeting signals of phospholipase D1 involving lipid modification of a pleckstrin homology domain

31 March 2020

1 reference

Structural analysis of human phospholipase D1.

31 March 2020

1 reference

Molecular analysis of mammalian phospholipase D2.

31 March 2020

1 reference

Regulation of phospholipase D1 subcellular cycling through coordination of multiple membrane association motifs.

31 March 2020

1 reference

Mechanism of membrane binding of the phospholipase D1 PX domain

31 March 2020

1 reference

Phosphatidylinositol (3,4,5)-trisphosphate specifically interacts with the phox homology domain of phospholipase D1 and stimulates its activity

31 March 2020

1 reference

The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis.

31 March 2020

1 reference

Phospholipase D2 induces stress fiber formation through mediating nucleotide exchange for RhoA.

31 March 2020

1 reference

The exquisite regulation of PLD2 by a wealth of interacting proteins: S6K, Grb2, Sos, WASp and Rac2 (and a surprise discovery: PLD2 is a GEF).

31 March 2020

1 reference

Phospholipase D signaling: orchestration by PIP2 and small GTPases

31 March 2020

1 reference

Localization of VEGFR-2 and PLD2 in endothelial caveolae is involved in VEGF-induced phosphorylation of MEK and ERK.

31 March 2020

1 reference

Phospholipase A(2): new lessons from endothelial cells

31 March 2020

1 reference

Regulation of phosphoinositide-specific phospholipase C

31 March 2020

1 reference

The roles of phospholipase D in EGFR signaling

31 March 2020

1 reference

Phospholipase C-gamma1 in tumor progression.

31 March 2020

1 reference

Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development

31 March 2020

1 reference

Direct interaction of SOS1 Ras exchange protein with the SH3 domain of phospholipase C-gamma1

31 March 2020

1 reference

Phospholipase C(epsilon): a novel Ras effector

31 March 2020

1 reference

Structural and mechanistic insights into ras association domains of phospholipase C epsilon

31 March 2020

1 reference

A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway

31 March 2020

1 reference

Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development

31 March 2020

1 reference

Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis

31 March 2020

1 reference

Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5.

31 March 2020

1 reference

Phosphoinositide-phospholipase C beta1 mono-allelic deletion is associated with myelodysplastic syndromes evolution into acute myeloid leukemia.

31 March 2020

1 reference

Characterization of a novel tumor-suppressor gene PLC delta 1 at 3p22 in esophageal squamous cell carcinoma

31 March 2020

1 reference

Phospholipase Cdelta1 is required for skin stem cell lineage commitment

31 March 2020

1 reference

Multiple sources of sn-1,2-diacylglycerol in platelet-derived-growth-factor-stimulated Swiss 3T3 fibroblasts. Evidence for activation of phosphoinositidase C and phosphatidylcholine-specific phospholipase D.

31 March 2020

1 reference

Induction of phosphatidic acid by fibroblast growth factor in cultured baby hamster kidney fibroblasts.

31 March 2020

1 reference

Ral and Rho-dependent activation of phospholipase D in v-Raf-transformed cells

31 March 2020

1 reference

v-Src increases diacylglycerol levels via a type D phospholipase-mediated hydrolysis of phosphatidylcholine

31 March 2020

1 reference

Phospholipase D and RalA cooperate with the epidermal growth factor receptor to transform 3Y1 rat fibroblasts

31 March 2020

1 reference

Transformation of cells overexpressing a tyrosine kinase by phospholipase D1 and D2.

31 March 2020

1 reference

Phospholipase D and its product, phosphatidic acid, mediate agonist-dependent raf-1 translocation to the plasma membrane and the activation of the mitogen-activated protein kinase pathway

31 March 2020

1 reference

Phosphatidic acid-mediated mitogenic activation of mTOR signaling

31 March 2020

1 reference

Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin

31 March 2020

1 reference

mTOR, translation initiation and cancer

31 March 2020

1 reference

The genomic landscapes of human breast and colorectal cancers

31 March 2020

1 reference

Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology

31 March 2020

1 reference

Prostaglandins and leukotrienes: advances in eicosanoid biology

31 March 2020

1 reference

Deletion of cytosolic phospholipase A(2) suppresses Apc(Min)-induced tumorigenesis

31 March 2020

1 reference

Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)

31 March 2020

1 reference

Decreased lung tumorigenesis in mice genetically deficient in cytosolic phospholipase A2.

31 March 2020

1 reference

The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia

31 March 2020

1 reference

Expression analysis of the group IIA secretory phospholipase A(2) in mice with differential susceptibility to azoxymethane-induced colon tumorigenesis.

31 March 2020

1 reference

The emerging role of lysophosphatidic acid in cancer

31 March 2020

1 reference

Prostaglandins and cancer

31 March 2020

1 reference

Lysophospholipids activate ovarian and breast cancer cells

31 March 2020

1 reference

Lysophospholipid growth factors in the initiation, progression, metastases, and management of ovarian cancer.

31 March 2020

1 reference

Abnormal serum lysophospholipids in multiple myeloma patients

31 March 2020

1 reference

Lysophosphatidic acid, a novel lipid growth factor for human thyroid cells: over-expression of the high-affinity receptor edg4 in differentiated thyroid cancer

31 March 2020

1 reference

Rac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiam1

31 March 2020

1 reference

31 March 2020

Eicosanoids and cancer

1 reference

Inflammation meets cancer, with NF-κB as the matchmaker

31 March 2020

1 reference

Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship?.

31 March 2020

1 reference

Transcription factors control invasion: AP-1 the first among equals

31 March 2020

1 reference

Oxidative stress, inflammation, and cancer: how are they linked?

31 March 2020

1 reference

Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation

31 March 2020

1 reference

The cofilin pathway in breast cancer invasion and metastasis

31 March 2020

1 reference

Role of phospholipase Cgamma1 in cell spreading requires association with a beta-Pix/GIT1-containing complex, leading to activation of Cdc42 and Rac1.

31 March 2020

1 reference

Phospholipase Cgamma1 is required for metastasis development and progression

31 March 2020

1 reference

Phospholipase C-β2 promotes mitosis and migration of human breast cancer-derived cells

31 March 2020

1 reference

Phospholipase D2 stimulates cell protrusion in v-Src-transformed cells

31 March 2020

1 reference

Phospholipase D activity regulates integrin-mediated cell spreading and migration by inducing GTP-Rac translocation to the plasma membrane

31 March 2020

1 reference

Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation

31 March 2020

1 reference

Phorbol ester up-regulates phospholipase D1 but not phospholipase D2 expression through a PKC/Ras/ERK/NFkappaB-dependent pathway and enhances matrix metalloproteinase-9 secretion in colon cancer cells

31 March 2020

1 reference

Overexpression of phospholipase D enhances matrix metalloproteinase-2 expression and glioma cell invasion via protein kinase C and protein kinase A/NF-kappaB/Sp1-mediated signaling pathways

31 March 2020

1 reference

Phospholipase D couples survival and migration signals in stress response of human cancer cells

31 March 2020

1 reference

Effects of active and inactive phospholipase D2 on signal transduction, adhesion, migration, invasion, and metastasis in EL4 lymphoma cells

31 March 2020

1 reference

phospholipase C gamma-1 is required downstream of vascular endothelial growth factor during arterial development

31 March 2020

1 reference

Absence of erythrogenesis and vasculogenesis in Plcg1-deficient mice

31 March 2020

1 reference

A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells

31 March 2020

1 reference

Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice

31 March 2020

1 reference

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

31 March 2020

1 reference

Distinct role of PLCbeta3 in VEGF-mediated directional migration and vascular sprouting

31 March 2020

1 reference

Phospholipase C-delta1 and -delta3 are essential in the trophoblast for placental development

31 March 2020

1 reference

Phospholipase D1 is required for angiogenesis of intersegmental blood vessels in zebrafish

31 March 2020

1 reference

The sphingosine-1-phosphate receptors S1P1, S1P2, and S1P3 function coordinately during embryonic angiogenesis

31 March 2020

1 reference

Sphingosine kinase 1 is an intracellular effector of phosphatidic acid

31 March 2020

1 reference

CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer

31 March 2020

1 reference

Cytosolic phospholipase A2-alpha mediates endothelial cell proliferation and is inactivated by association with the Golgi apparatus.

31 March 2020

1 reference

Activation of cytosolic phospholipase A2-{alpha} as a novel mechanism regulating endothelial cell cycle progression and angiogenesis

31 March 2020

1 reference

Cytosolic phospholipase A2 regulates viability of irradiated vascular endothelium

31 March 2020

1 reference

Cytosolic Phospholipase A2 and Cancer: A Role in Tumor Angiogenesis

31 March 2020

1 reference

Cytosolic Phospholipase A2 and Lysophospholipids in Tumor Angiogenesis

31 March 2020

1 reference

Cellular function of calcium-independent phospholipase A2.

31 March 2020

1 reference

Involvement of cytosolic phospholipase A(2), calcium independent phospholipase A(2) and plasmalogen selective phospholipase A(2) in neurodegenerative and neuropsychiatric conditions

31 March 2020

1 reference

Cyclooxygenase-2 inhibition prevents colorectal cancer: from the bench to the bed side

31 March 2020

1 reference

Progress in COX-2 inhibitors: a journey so far.

31 March 2020

1 reference

Varespladib (A-002), a secretory phospholipase A2 inhibitor, reduces atherosclerosis and aneurysm formation in ApoE-/- mice

31 March 2020

1 reference

5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis

31 March 2020

1 reference

Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness

31 March 2020

1 reference

Phospholipase C is a key enzyme regulating intracellular calcium and modulating the phosphoinositide balance

31 March 2020

1 reference

Role of the CDC25 homology domain of phospholipase Cepsilon in amplification of Rap1-dependent signaling

31 March 2020

1 reference

Phospholipase D: a lipid centric review

31 March 2020

1 reference

Expression of a novel murine phospholipase D homolog coincides with late neuronal development in the forebrain

31 March 2020

1 reference

Phospholipase D family member 4, a transmembrane glycoprotein with no phospholipase D activity, expression in spleen and early postnatal microglia

31 March 2020

1 reference

A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis

31 March 2020

1 reference

PLD$ is involved in phagocytosis of microglia: expression and localization changes of PLD4 are correlated with activation state of microglia

31 March 2020

1 reference

Phosphorylation and activation of phospholipase D1 by protein kinase C in vivo: determination of multiple phosphorylation sites

31 March 2020

1 reference

Characterization of two alternately spliced forms of phospholipase D1. Activation of the purified enzymes by phosphatidylinositol 4,5-bisphosphate, ADP-ribosylation factor, and Rho family monomeric GTP-binding proteins and protein kinase C-alpha

31 March 2020

1 reference

Two pathways for lysophosphatidic acid production

31 March 2020

1 reference

The Mom1AKR intestinal tumor resistance region consists of Pla2g2a and a locus distal to D4Mit64

31 March 2020

1 reference

Cytoplasmic phospholipase A2 deletion enhances colon tumorigenesis

31 March 2020

1 reference

Platelet-activating factor and metastasis: calcium-independent phospholipase A2β deficiency protects against breast cancer metastasis to the lung

31 March 2020

1 reference

Group VIA phospholipase A2 in both host and tumor cells is involved in ovarian cancer development

31 March 2020

1 reference

PLC gamma contributes to metastasis of in situ-occurring mammary and prostate tumors

31 March 2020

1 reference

Essential role of phospholipase C gamma 2 in early B-cell development and Myc-mediated lymphomagenesis.

31 March 2020

1 reference

Enhancement of ultraviolet B-induced skin tumor development in phospholipase Cε -knockout mice is associated with decreased cell death

31 March 2020

1 reference

Broad, ectopic expression of the sperm protein PLCZ1 induces parthenogenesis and ovarian tumours in mice

31 March 2020

1 reference

Expression of group-II phospholipase A2 in malignant and non-malignant human gastric mucosa

31 March 2020

1 reference

Overexpression of group II phospholipase A2 in human breast cancer tissues is closely associated with their malignant potency

31 March 2020

1 reference

PLA2 (group IIA phospholipase A2) as a prognostic determinant in stage II colorectal carcinoma

31 March 2020

1 reference

Inhibition of gastric cancer invasion and metastasis by PLA2G2A, a novel beta-catenin/TCF target gene

31 March 2020

1 reference

Expression of group IIA secretory phospholipase A2 is elevated in prostatic intraepithelial neoplasia and adenocarcinoma

31 March 2020

1 reference

Cytoplasmic phospholipase A2 levels correlate with apoptosis in human colon tumorigenesis

31 March 2020

1 reference

Identification of novel oligodendroglioma-associated candidate tumor suppressor genes in 1p36 and 19q13 using microarray-based expression profiling.

31 March 2020

1 reference

Elevated content of phospholipase C-gamma 1 in colorectal cancer tissues.

31 March 2020

1 reference

Elevated content of the tyrosine kinase substrate phospholipase C-gamma 1 in primary human breast carcinomas

31 March 2020

1 reference

Phospholipase C delta 1 is a novel 3p22.3 tumor suppressor involved in cytoskeleton organization, with its epigenetic silencing correlated with high-stage gastric cancer.

31 March 2020

1 reference

Overexpression of phospholipase D1 in human breast cancer tissues

31 March 2020

1 reference

Increased activity and intranuclear expression of phospholipase D2 in human renal cancer

31 March 2020

1 reference

Cell membrane lipid composition and distribution: implications for cell function and lessons learned from photoreceptors and platelets

31 March 2020

1 reference

12 December 2020

Epidermal growth factor receptor-stimulated activation of phospholipase Cgamma-1 promotes invasion of head and neck squamous cell carcinoma

1 reference

12 December 2020

Activation of type D phospholipase by serum stimulation and ras-induced transformation in NIH3T3 cells

1 reference

12 December 2020

PLC-beta2 is highly expressed in breast cancer and is associated with a poor outcome: a study on tissue microarrays

1 reference

12 December 2020

Expression of group IIa secretory phospholipase A2 increases with prostate tumor grade.

1 reference

12 December 2020

Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos.

1 reference

12 December 2020

Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer

1 reference

12 December 2020

Lysophosphatidic acid induces urokinase secretion by ovarian cancer cells

1 reference

12 December 2020

Prostaglandin E2 induces vascular endothelial growth factor and basic fibroblast growth factor mRNA expression in cultured rat Müller cells.

1 reference

12 December 2020

Expression of phospholipase D2 in human colorectal carcinoma

1 reference

12 December 2020

Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis

1 reference

12 December 2020

Epidermal growth factor induces the production of biologically distinguishable diglyceride species from phosphatidylinositol and phosphatidylcholine via the independent activation of type C and type D phospholipases.

1 reference

12 December 2020

Eicosanoids and cancer

1 reference

12 December 2020

Multiple roles of phosphoinositide-specific phospholipase C isozymes

1 reference

12 December 2020

Expression of phospholipase C-gamma 1 and its transcriptional regulators in breast cancer tissues

1 reference

12 December 2020

Vascular endothelial growth factor stimulates protein kinase C-dependent phospholipase D activity in endothelial cells

1 reference

12 December 2020