(Q85406998)

English

Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 as monotherapy in patients with hypercholesterolaemia (MENDEL): a randomised, double-blind, placebo-controlled, phase 2 study

scientific article published on 06 November 2012

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17 February 2020

Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 as monotherapy in patients with hypercholesterolaemia (MENDEL): a randomised, double-blind, placebo-controlled, phase 2 study (English)

1 reference

Europe PubMed Central

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17 February 2020

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monoclonal antibody

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author name string

Michael J Koren

1

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Europe PubMed Central

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17 February 2020

Rob Scott

2

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17 February 2020

Jae B Kim

3

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17 February 2020

Beat Knusel

4

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17 February 2020

Thomas Liu

5

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17 February 2020

Lei Lei

6

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17 February 2020

Michael Bolognese

7

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Europe PubMed Central

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17 February 2020

Scott M Wasserman

8

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17 February 2020

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publication date

6 November 2012

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17 February 2020

1 reference

Europe PubMed Central

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17 February 2020

380

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17 February 2020

9858

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17 February 2020

1995-2006

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17 February 2020

ESC/EAS Guidelines for the management of dyslipidaemias: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS).

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2961771-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2961771-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2961771-1

7 January 2021

based on heuristic

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Canadian Cardiovascular Society position statement--recommendations for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2961771-1

7 January 2021

based on heuristic

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Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2961771-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients--the PRIMO study

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2961771-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2961771-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2961771-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular biology of PCSK9: its role in LDL metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2961771-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Genetic and metabolic determinants of plasma PCSK9 levels

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2961771-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2961771-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2961771-1

7 January 2021

based on heuristic

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Narrative review: statin-related myopathy

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2961771-1

7 January 2021

based on heuristic

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An assessment of statin safety by hepatologists

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2961771-1

7 January 2021

based on heuristic

inferred from DOI database lookup

ACC/AHA/NHLBI Clinical Advisory on the Use and Safety of Statins

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2961771-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Compliance with fluvastatin treatment characterization of the noncompliant population within a population of 3845 patients with hyperlipidemia. CREOLE Study Team

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2961771-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Statin-related adverse events: a meta-analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2961771-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of fibrates in cardiovascular disease prevention, the ACCORD-Lipid perspective

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2961771-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of ezetimibe in patients who cannot tolerate statins or cannot get to the low density lipoprotein cholesterol target despite taking a statin.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2961771-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Outcomes in 45 patients with statin-associated myopathy

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2961771-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Safety and efficacy of long-term co-administration of fenofibrate and ezetimibe in patients with mixed hyperlipidemia

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2961771-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Safety and efficacy of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease, SAR236553/REGN727, in patients with primary hypercholesterolemia receiving ongoing stable atorvastatin therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2961771-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of a monoclonal antibody to PCSK9, REGN727/SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy: a phase 2 randomised con

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2961771-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0140-6736(12)61771-1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23141812%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23141812%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

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