(Q85590862)

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NMDA Receptors and Oxidative Stress Induced by the Major Metabolites Accumulating in HMG Lyase Deficiency Mediate Hypophosphorylation of Cytoskeletal Proteins in Brain From Adolescent Rats: Potential Mechanisms Contributing to the Neuropathology of

scientific article published on 15 July 2015

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19 February 2020

NMDA Receptors and Oxidative Stress Induced by the Major Metabolites Accumulating in HMG Lyase Deficiency Mediate Hypophosphorylation of Cytoskeletal Proteins in Brain From Adolescent Rats: Potential Mechanisms Contributing to the Neuropathology of This Disease (English)

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19 February 2020

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Moacir Wajner

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19 February 2020

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Carolina Gonçalves Fernandes

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19 February 2020

Paula Pierozan

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19 February 2020

Gilberto Machado Soares

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19 February 2020

Fernanda Ferreira

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19 February 2020

Ângela Zanatta

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19 February 2020

Alexandre Umpierrez Amaral

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19 February 2020

Clarissa Günther Borges

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19 February 2020

Regina Pessoa-Pureur

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19 February 2020

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15 July 2015

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19 February 2020

Neurotoxicity Research

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19 February 2020

28

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19 February 2020

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19 February 2020

239-252

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19 February 2020

https://scigraph.springernature.com/pub.10.1007/s12640-015-9542-z

0 references

Effect of propionic and methylmalonic acids on the in vitro phosphorylation of intermediate filaments from cerebral cortex of rats during development

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

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Neuronal intermediate filaments and neurodegenerative disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of NOS1AP action on NMDA receptor-nNOS signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NMDA receptor-mediated excitotoxicity depends on the coactivation of synaptic and extrasynaptic receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methylmalonate inhibits succinate-supported oxygen consumption by interfering with mitochondrial succinate uptake

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Propylthiouracil-induced congenital hypothyroidism upregulates vimentin phosphorylation and depletes antioxidant defenses in immature rat testis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of the GluN2A and GluN2B subunits in synaptic and extrasynaptic N-methyl-D-aspartate receptor function and neuronal excitotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Study of proline-directed protein kinases involved in phosphorylation of the heavy neurofilament subunit.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extinction of remotely acquired fear depends on an inhibitory NR2B/PKA pathway in the retrosplenial cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute intrastriatal injection of quinolinic acid provokes long-lasting misregulation of the cytoskeleton in the striatum, cerebral cortex and hippocampus of young rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methylglyoxal-induced cytotoxicity in neonatal rat brain: a role for oxidative stress and MAP kinases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Safranine as a probe of the mitochondrial membrane potential

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytoskeleton of cortical astrocytes as a target to proline through oxidative stress mechanisms.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical physiology and mechanism of dizocilpine (MK-801): electron transfer, radicals, redox metabolites and bioactivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Redox homeostasis is compromised in vivo by the metabolites accumulating in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency in rat cerebral cortex and liver.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vimentin phosphorylation as a target of cell signaling mechanisms induced by 1alpha,25-dihydroxyvitamin D3 in immature rat testes

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation protects neurofilaments against proteolysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of cytochrome c oxidase activity in rat cerebral cortex and human skeletal muscle by D-2-hydroxyglutaric acid in vitro.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-beta peptide 1-42 causes microtubule deregulation through N-methyl-D-aspartate receptors in mature hippocampal cultures.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of oxidative stress by the metabolites accumulating in 3-methylglutaconic aciduria in cerebral cortex of young rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo experimental evidence that the major metabolites accumulating in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency induce oxidative stress in striatum of developing rats: a potential pathophysiological mechanism of striatal damage in this diso

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Experimental evidence that ornithine and homocitrulline disrupt energy metabolism in brain of young rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that 3-hydroxy-3-methylglutaric acid promotes lipid and protein oxidative damage and reduces the nonenzymatic antioxidant defenses in rat cerebral cortex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein serine/threonine phosphatase 1 and 2A associate with and dephosphorylate neurofilaments.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential investigation of the capacity of succinate oxidation in human skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute intrastriatal administration of quinolinic acid provokes hyperphosphorylation of cytoskeletal intermediate filament proteins in astrocytes and neurons of rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitogen-activated protein kinases (Erk1,2) phosphorylate Lys-Ser-Pro (KSP) repeats in neurofilament proteins NF-H and NF-M.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diphenyl ditelluride induces hypophosphorylation of intermediate filaments through modulation of DARPP-32-dependent pathways in cerebral cortex of young rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The activation of aconitase by ferrous ions and reducing agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurofilament protein synthesis and phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dephosphorylation of neurofilament proteins enhances their susceptibility to degradation by calpain

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular phosphorylation of neurofilament heavy-chain by cyclin-dependent kinase-5 masks the epitope for monoclonal antibody N52.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cdk5 and MAPK are associated with complexes of cytoskeletal proteins in rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro phosphorylation of cytoskeletal proteins from cerebral cortex of rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo phosphorylation of distinct domains of the 70-kilodalton neurofilament subunit involves different protein kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-ketoisocaproic acid increases phosphorylation of intermediate filament proteins from rat cerebral cortex by mechanisms involving Ca2+ and cAMP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of neurofilament heavy chain side-arms by stress activated protein kinase-1b/Jun N-terminal kinase-3

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homocysteine induces cytoskeletal remodeling and production of reactive oxygen species in cultured cortical astrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disrupted cytoskeletal homeostasis, astrogliosis and apoptotic cell death in the cerebellum of preweaning rats injected with diphenyl ditelluride

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynorphin up-regulation in the dentate granule cell mossy fiber pathway following chronic inhibition of GluN2B-containing NMDAR is associated with increased CREB (Ser 133) phosphorylation, but is independent of BDNF/TrkB signaling pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Congenital hypothyroidism alters the oxidative status, enzyme activities and morphological parameters in the hippocampus of developing rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical and molecular investigations in respiratory chain deficiencies

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of the Ser-Thr phosphatases PP1 and PP2A by naturally occurring toxins

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3-Hydroxy-3-methylglutaryl-coenzyme a lyase deficiency: a review

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GFAP in health and disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Patient with Defect in Leucine Metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of energy metabolism in cerebral cortex of young rats by the medium-chain fatty acids accumulating in MCAD deficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of phosphorylation on the structural dynamics and function of types III and IV intermediate filaments

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Striatum is more vulnerable to oxidative damage induced by the metabolites accumulating in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency as compared to liver.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurochemical evidence that 3-methylglutaric acid inhibits synaptic Na+,K+-ATPase activity probably through oxidative damage in brain cortex of young rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of Krebs cycle enzymes by hydrogen peroxide: A key role of [alpha]-ketoglutarate dehydrogenase in limiting NADH production under oxidative stress.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo treatment with diphenyl ditelluride induces neurodegeneration in striatum of young rats: implications of MAPK and Akt pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MRI and MRS in HMG-CoA lyase deficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-based design of a highly selective catalytic site-directed inhibitor of Ser/Thr protein phosphatase 2B (calcineurin).

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial permeability transition and oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Corticospinal tract involvement in a patient with 3-HMG coenzyme A lyase deficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that intracellular Ca2+ mediates the effect of alpha-ketoisocaproic acid on the phosphorylating system of cytoskeletal proteins from cerebral cortex of immature rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of phosphorylation of the neurofilament L protein on filamentous structures

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide negatively regulates c-Jun N-terminal kinase/stress-activated protein kinase by means of S-nitrosylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NMDA receptor GluN2B (GluR epsilon 2/NR2B) subunit is crucial for channel function, postsynaptic macromolecular organization, and actin cytoskeleton at hippocampal CA3 synapses

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3-Hydroxy-3-methylglutaryl-coenzyme A lyase deficiency: review of 18 reported patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MR imaging and proton spectroscopy in 3-hydroxy-3-methylglutaryl coenzyme A lyase deficiency.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein measurement with the Folin phenol reagent

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies of catecholamine shock. I. Disseminated intravascular coagulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebral ischemia and reperfusion: prevention of brain mitochondrial injury by lidoflazine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signaling mechanisms downstream of quinolinic acid targeting the cytoskeleton of rat striatal neurons and astrocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular genetics of HMG-CoA lyase deficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3-Hydroxy-3-methylglutaryl-coenzyme A lyase deficiency: initial presentation in a young adult

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homocysteine induces hypophosphorylation of intermediate filaments and reorganization of actin cytoskeleton in C6 glioma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain alpha-ketoglutarate dehydrogenase complex: kinetic properties, regional distribution, and effects of inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro phosphorylation of cytoskeletal proteins in the rat cerebral cortex is decreased by propionic acid.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ethylmalonic encephalopathy: clinical and biochemical observations

1 reference

https://pubmed.ncbi.nlm.nih.gov/26174040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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