(Q86243687)

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Contribution of enhanced engagement of antigen presentation machinery to the clinical immunogenicity of a human interleukin (IL)-21 receptor-blocking therapeutic antibody

scientific article published on 05 November 2015

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24 February 2020

Contribution of enhanced engagement of antigen presentation machinery to the clinical immunogenicity of a human interleukin (IL)-21 receptor-blocking therapeutic antibody (English)

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Europe PubMed Central

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24 February 2020

author name string

L Xue

1

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24 February 2020

T Hickling

2

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24 February 2020

R Song

3

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24 February 2020

J Nowak

4

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24 February 2020

B Rup

5

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24 February 2020

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5 November 2015

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24 February 2020

Clinical and Experimental Immunology

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24 February 2020

183

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24 February 2020

1

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24 February 2020

102-113

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Europe PubMed Central

PubMed publication ID

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24 February 2020

T follicular helper cells mediate expansion of regulatory B cells via IL-21 in Lupus-prone MRL/lpr mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-IL21 receptor monoclonal antibody (ATR-107): Safety, pharmacokinetics, and pharmacodynamic evaluation in healthy volunteers: a phase I, first-in-human study

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The immunogenicity of humanized and fully human antibodies: residual immunogenicity resides in the CDR regions

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of MHC class II binding affinity using SMM-align, a novel stabilization matrix alignment method

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dendritic-cell immunotherapy: from ex vivo loading to in vivo targeting

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

B-cell memory and primary immune deficiencies: interleukin-21 related defects

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cytokine profile expressed by human dendritic cells is dependent on cell subtype and mode of activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-21 receptor is critical for the development of memory B cell responses.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The nature of activatory and tolerogenic dendritic cell-derived signal II.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro potency, pharmacokinetic profiles, and pharmacological activity of optimized anti-IL-21R antibodies in a mouse model of lupus

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endosomal sorting of MHC class II determines antigen presentation by dendritic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanisms of T cell co-stimulation and co-inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokine and chemokine expression profiles of maturing dendritic cells using multiprotein platform arrays

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Manipulation of dendritic cells as an approach to improved outcomes in transplantation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dendritic cells and cytokines in human inflammatory and autoimmune diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of well-conserved HIV-1 ligands using a matrix-based algorithm, EpiMatrix.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Several common HLA-DR types share largely overlapping peptide binding repertoires

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Considerations for optimization and validation of an in vitro PBMC derived T cell assay for immunogenicity prediction of biotherapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Automated generation and evaluation of specific MHC binding predictive tools: ARB matrix applications.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-21 enhances phagocytosis in mononuclear phagocyte cells: identification of spleen tyrosine kinase as a novel molecular target of IL-21.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dendritic cells: emerging pharmacological targets of immunosuppressive drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical validation of the "in silico" prediction of immunogenicity of a human recombinant therapeutic protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation of tissue-specific and promiscuous HLA ligand databases using DNA microarrays and virtual HLA class II matrices

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased production of pro-inflammatory cytokines and enhanced T cell responses after activation of human dendritic cells with IL-1 and CD40 ligand

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ins and outs of MHC class II-mediated antigen processing and presentation

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 21: a cytokine/cytokine receptor system that has come of age

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessing agonistic potential of a candidate therapeutic anti-IL21R antibody

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aggregation of human recombinant monoclonal antibodies influences the capacity of dendritic cells to stimulate adaptive T-cell responses in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Controlling immune responses by targeting antigens to dendritic cell subsets and B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-21 inhibits dendritic cell activation and maturation

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The known unknowns of antigen processing and presentation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dendritic cells in vivo: a key target for a new vaccine science

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-21: a double-edged sword with therapeutic potential

1 reference

https://pubmed.ncbi.nlm.nih.gov/26400440

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/CEI.12711

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26400440%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26400440%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

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