(Q38365560)

30 June 2019

review article

1 reference

title

The ins and outs of MHC class II-mediated antigen processing and presentation (English)

1 reference

30 June 2019

author name string

Paul A Roche

series ordinal

1

1 reference

30 June 2019

Kazuyuki Furuta

series ordinal

2

1 reference

30 June 2019

publication date

27 February 2015

1 reference

30 June 2019

Nature Reviews Immunology

published in

1 reference

30 June 2019

volume

15

1 reference

30 June 2019

page(s)

203-216

1 reference

30 June 2019

issue

4

1 reference

30 June 2019

https://scigraph.springernature.com/pub.10.1038/nri3818

exact match

0 references

cites work

Immunobiology of dendritic cells

1 reference

Early events in B cell activation

21 January 2018

1 reference

Cell biology of antigen processing in vitro and in vivo

21 January 2018

1 reference

Pathways of antigen processing

21 January 2018

1 reference

Mass spectrometry analysis and quantitation of peptides presented on the MHC II molecules of mouse spleen dendritic cells

21 January 2018

1 reference

Invariant chain structure and MHC class II function

21 January 2018

1 reference

AP2 clathrin adaptor complex, but not AP1, controls the access of the major histocompatibility complex (MHC) class II to endosomes.

21 January 2018

1 reference

Involvement of clathrin and AP-2 in the trafficking of MHC class II molecules to antigen-processing compartments

21 January 2018

1 reference

Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization

21 January 2018

1 reference

Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding

21 January 2018

1 reference

Achieving stability through editing and chaperoning: regulation of MHC class II peptide binding and expression

21 January 2018

1 reference

Right place, right time, right peptide: DO keeps DM focused

21 January 2018

1 reference

Macropinocytosis: an endocytic pathway for internalising large gulps

21 January 2018

1 reference

Virus entry by macropinocytosis

21 January 2018

1 reference

The lymph as a pool of self-antigens

21 January 2018

1 reference

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products

21 January 2018

1 reference

Enhanced Dendritic Cell Antigen Capture via Toll-Like Receptor-Induced Actin Remodeling

21 January 2018

1 reference

Developmental control of endocytosis in dendritic cells by Cdc42.

21 January 2018

1 reference

Phagocytosis of antigens by Langerhans cells in vitro

21 January 2018

1 reference

Mature dendritic cells use endocytic receptors to capture and present antigens

21 January 2018

1 reference

Dendritic cell preactivation impairs MHC class II presentation of vaccines and endogenous viral antigens

21 January 2018

1 reference

Dendritic cells continue to capture and present antigens after maturation in vivo

21 January 2018

1 reference

Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors

21 January 2018

1 reference

Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex

21 January 2018

1 reference

Antibody modulation of antigen presentation: positive and negative effects on presentation of the tetanus toxin antigen via the murine B cell isoform of FcgammaRII.

21 January 2018

1 reference

In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination

21 January 2018

1 reference

Robust T-cell stimulation by Epstein-Barr virus-transformed B cells after antigen targeting to DEC-205.

21 January 2018

1 reference

Phagocytosis: elegant complexity

21 January 2018

1 reference

Membrane transfer from tumor cells overcomes deficient phagocytic ability of plasmacytoid dendritic cells for the acquisition and presentation of tumor antigens

21 January 2018

1 reference

The induction of tolerance by dendritic cells that have captured apoptotic cells

21 January 2018

1 reference

Differential role of actin, clathrin, and dynamin in Fc gamma receptor-mediated endocytosis and phagocytosis

21 January 2018

1 reference

ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells

21 January 2018

1 reference

Phagosomes are competent organelles for antigen cross-presentation

21 January 2018

1 reference

Cross-presentation by dendritic cells

21 January 2018

1 reference

Regulation of phagosome maturation by signals from toll-like receptors.

21 January 2018

1 reference

Adaptor protein-3 in dendritic cells facilitates phagosomal toll-like receptor signaling and antigen presentation to CD4(+) T cells

21 January 2018

1 reference

Autonomous phagosomal degradation and antigen presentation in dendritic cells

21 January 2018

1 reference

TLR-dependent phagosome tubulation in dendritic cells promotes phagosome cross-talk to optimize MHC-II antigen presentation

21 January 2018

1 reference

Exploring the MHC-peptide matrix of central tolerance in the human thymus.

21 January 2018

1 reference

LAMP-2-deficient human B cells exhibit altered MHC class II presentation of exogenous antigens

21 January 2018

1 reference

Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes

21 January 2018

1 reference

Endogenous MHC class II processing of a viral nuclear antigen after autophagy.

21 January 2018

1 reference

Autophagy in antigen-presenting cells results in presentation of citrullinated peptides to CD4 T cells

21 January 2018

1 reference

Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis

21 January 2018

1 reference

Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance

21 January 2018

1 reference

Macroautophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central tolerance

21 January 2018

1 reference

In vivo requirement for Atg5 in antigen presentation by dendritic cells

21 January 2018

1 reference

Asparagine endopeptidase can initiate the removal of the MHC class II invariant chain chaperone.

21 January 2018

1 reference

Cathepsin S required for normal MHC class II peptide loading and germinal center development

21 January 2018

1 reference

Activation of lysosomal function during dendritic cell maturation

21 January 2018

1 reference

The formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli

21 January 2018

1 reference

Destructive processing by asparagine endopeptidase limits presentation of a dominant T cell epitope in MBP.

21 January 2018

1 reference

Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate

21 January 2018

1 reference

The small GTPase Rac2 controls phagosomal alkalinization and antigen crosspresentation selectively in CD8(+) dendritic cells

21 January 2018

1 reference

Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing.

21 January 2018

1 reference

Regulation of MHC class II gene expression by the class II transactivator

21 January 2018

1 reference

Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA.

21 January 2018

1 reference

Dendritic cells constitutively present self antigens in their immature state in vivo and regulate antigen presentation by controlling the rates of MHC class II synthesis and endocytosis.

21 January 2018

1 reference

Differential MHC class II synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cells

21 January 2018

1 reference

MHC class II expression is differentially regulated in plasmacytoid and conventional dendritic cells.

21 January 2018

1 reference

Antigen-presentation properties of plasmacytoid dendritic cells

21 January 2018

1 reference

Control of MHC class II antigen presentation in dendritic cells: a balance between creative and destructive forces.

21 January 2018

1 reference

Class II MHC molecules are present in macrophage lysosomes and phagolysosomes that function in the phagocytic processing of Listeria monocytogenes for presentation to T cells

21 January 2018

1 reference

Developmental regulation of MHC class II transport in mouse dendritic cells.

21 January 2018

1 reference

Endosomally stored MHC class II does not contribute to antigen presentation by dendritic cells at inflammatory conditions.

21 January 2018

1 reference

Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells

21 January 2018

1 reference

Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cells

21 January 2018

1 reference

T-cell engagement of dendritic cells rapidly rearranges MHC class II transport.

21 January 2018

1 reference

Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane.

21 January 2018

1 reference

Dynamics of major histocompatibility complex class II compartments during B cell receptor-mediated cell activation

21 January 2018

1 reference

The actin-based motor protein myosin II regulates MHC class II trafficking and BCR-driven antigen presentation.

21 January 2018

1 reference

Syk-dependent actin dynamics regulate endocytic trafficking and processing of antigens internalized through the B-cell receptor

21 January 2018

1 reference

Pathogenic CD4⁺ T cells recognizing an unstable peptide of insulin are directly recruited into islets bypassing local lymph nodes.

21 January 2018

1 reference

Polarized secretion of lysosomes at the B cell synapse couples antigen extraction to processing and presentation.

21 January 2018

1 reference

MHC class II molecules on the move for successful antigen presentation

21 January 2018

1 reference

TRIF-GEFH1-RhoB pathway is involved in MHCII expression on dendritic cells that is critical for CD4 T-cell activation

21 January 2018

1 reference

A Genome-wide multidimensional RNAi screen reveals pathways controlling MHC class II antigen presentation

21 January 2018

1 reference

Indirect activation of naïve CD4+ T cells by dendritic cell-derived exosomes

21 January 2018

1 reference

ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming

21 January 2018

1 reference

T cell-induced secretion of MHC class II-peptide complexes on B cell exosomes

21 January 2018

1 reference

MHC II in dendritic cells is targeted to lysosomes or T cell-induced exosomes via distinct multivesicular body pathways.

21 January 2018

1 reference

Follicular dendritic cells carry MHC class II-expressing microvesicles at their surface

21 January 2018

1 reference

Dendritic cell-derived exosomes for cancer immunotherapy: what's next?

21 January 2018

1 reference

Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes

21 January 2018

1 reference

Tumour-derived exosomes as antigen delivery carriers in dendritic cell-based immunotherapy for malignant mesothelioma

21 January 2018

1 reference

Tetraspan microdomains distinct from lipid rafts enrich select peptide-MHC class II complexes

21 January 2018

1 reference

Concentration of MHC class II molecules in lipid rafts facilitates antigen presentation

21 January 2018

1 reference

Location of major histocompatibility complex class II molecules in rafts on dendritic cells enhances the efficiency of T-cell activation and proliferation

21 January 2018

1 reference

Major histocompatibility complex (MHC) class II-peptide complexes arrive at the plasma membrane in cholesterol-rich microclusters

21 January 2018

1 reference

MHC class II molecules traffic into lipid rafts during intracellular transport

21 January 2018

1 reference

Association of major histocompatibility complex II with cholesterol- and sphingolipid-rich membranes precedes peptide loading

21 January 2018

1 reference

Association of MHC class II-peptide complexes with plasma membrane lipid microdomains

21 January 2018

1 reference

Endocytosis and the recycling of plasma membrane

21 January 2018

1 reference

Epitope-specific enhancement of antigen presentation by invariant chain

21 January 2018

1 reference

A cytosolic pathway for MHC class II-restricted antigen processing that is proteasome and TAP dependent

21 January 2018

1 reference

Inhibition of MHC class II expression and immune responses by c-MIR

21 January 2018

1 reference

Dendritic cells regulate exposure of MHC class II at their plasma membrane by oligoubiquitination

21 January 2018

1 reference

Novel regulation of MHC class II function in B cells

21 January 2018

1 reference

MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation

21 January 2018

1 reference

Ubiquitination regulates MHC class II-peptide complex retention and degradation in dendritic cells

21 January 2018

1 reference

Sorting of MHC class II molecules into exosomes through a ubiquitin-independent pathway.

21 January 2018

1 reference

Encounter with antigen-specific primed CD4 T cells promotes MHC class II degradation in dendritic cells

21 January 2018

1 reference

Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins

21 January 2018

1 reference

MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells

21 January 2018

1 reference

Ubiquitination of CD86 is a key mechanism in regulating antigen presentation by dendritic cells

21 January 2018

1 reference

Ubiquitin-mediated regulation of CD86 protein expression by the ubiquitin ligase membrane-associated RING-CH-1 (MARCH1).

21 January 2018

1 reference

Interleukin-10-induced MARCH1 mediates intracellular sequestration of MHC class II in monocytes

21 January 2018

1 reference

Interleukin-10 down-regulates MHC class II alphabeta peptide complexes at the plasma membrane of monocytes by affecting arrival and recycling.

21 January 2018

1 reference

Dendritic cell activation prevents MHC class II ubiquitination and promotes MHC class II survival regardless of the activation stimulus

21 January 2018

1 reference

Discrete domains of MARCH1 mediate its localization, functional interactions, and posttranscriptional control of expression

21 January 2018

1 reference

Internalizing MHC class II-peptide complexes are ubiquitinated in early endosomes and targeted for lysosomal degradation

21 January 2018

1 reference

CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-driven MARCH1-mediated ubiquitination and degradation.

21 January 2018

1 reference

Identification of a novel motif that affects the conformation and activity of the MARCH1 E3 ubiquitin ligase

21 January 2018

1 reference

MHC class II distribution in dendritic cells and B cells is determined by ubiquitin chain length

21 January 2018

1 reference

Ubiquitin and membrane protein turnover: from cradle to grave

21 January 2018

1 reference

Viral subversion of the immune system

21 January 2018

1 reference

Salmonella regulates polyubiquitination and surface expression of MHC class II antigens

21 January 2018

1 reference

Francisella tularensis induces ubiquitin-dependent major histocompatibility complex class II degradation in activated macrophages

21 January 2018

1 reference

Francisella tularensis elicits IL-10 via a PGE₂-inducible factor, to drive macrophage MARCH1 expression and class II down-regulation

21 January 2018

1 reference

A coat protein on phagosomes involved in the intracellular survival of mycobacteria

21 January 2018

1 reference

Processing of Mycobacterium tuberculosis antigen 85B involves intraphagosomal formation of peptide-major histocompatibility complex II complexes and is inhibited by live bacilli that decrease phagosome maturation

21 January 2018

1 reference

Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages

21 January 2018

1 reference

Viral modulation of antigen presentation: manipulation of cellular targets in the ER and beyond

21 January 2018

1 reference

Inhibition of HLA-DR assembly, transport, and loading by human cytomegalovirus glycoprotein US3: a novel mechanism for evading major histocompatibility complex class II antigen presentation

21 January 2018

1 reference

Human cytomegalovirus protein pp65 mediates accumulation of HLA-DR in lysosomes and destruction of the HLA-DR alpha-chain.

21 January 2018

1 reference

The herpes simplex virus-1 encoded glycoprotein B diverts HLA-DR into the exosome pathway

21 January 2018

1 reference

Human immunodeficiency virus type 1 nef expression prevents AP-2-mediated internalization of the major histocompatibility complex class II-associated invariant chain.

21 January 2018

1 reference

Human immunodeficiency virus-1 Nef expression induces intracellular accumulation of multivesicular bodies and major histocompatibility complex class II complexes: potential role of phosphatidylinositol 3-kinase

21 January 2018

1 reference

Epstein-Barr virus evades CD4+ T cell responses in lytic cycle through BZLF1-mediated downregulation of CD74 and the cooperation of vBcl-2.

21 January 2018

1 reference

Epstein-Barr virus gp42 is posttranslationally modified to produce soluble gp42 that mediates HLA class II immune evasion.

21 January 2018

1 reference

Capture of cell-derived microvesicles (exosomes and apoptotic bodies) by human plasmacytoid dendritic cells

21 January 2018

1 reference

Toll-dependent selection of microbial antigens for presentation by dendritic cells

21 January 2018

1 reference

Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes

21 January 2018

1 reference

Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination

21 January 2018

1 reference

Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple compartments

21 January 2018

1 reference

CIIV, MIIC and other compartments for MHC class II loading

31 March 2020

1 reference

TLR signalling and phagosome maturation: an alternative viewpoint

31 March 2020

1 reference

Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice

31 March 2020

1 reference

Inflammatory stimuli recruit cathepsin activity to late endosomal compartments in human dendritic cells

31 March 2020

1 reference

Transport of peptide-MHC class II complexes in developing dendritic cells

31 March 2020

1 reference

Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells

31 March 2020

1 reference

Human resident langerhans cells display a lysosomal compartment enriched in MHC class II

31 March 2020

1 reference

The pathway of antigen uptake and processing dictates MHC class II-mediated B cell survival and activation

31 March 2020

1 reference

SWAP-70 regulates RhoA/RhoB-dependent MHCII surface localization in dendritic cells

31 March 2020

1 reference

MHC class II association with lipid rafts on the antigen presenting cell surface

31 March 2020

1 reference

Autoregulation of MARCH1 expression by dimerization and autoubiquitination

31 March 2020

1 reference

CD83 localization in a recycling compartment of immature human monocyte-derived dendritic cells

31 March 2020

1 reference

Cytomegalovirus US2 destroys two components of the MHC class II pathway, preventing recognition by CD4+ T cells

31 March 2020

2 references

31 March 2020

12 December 2020

Cutting edge: signals from the B lymphocyte antigen receptor regulate MHC class II containing late endosomes.

1 reference

12 December 2020

Autophagy and adaptive immunity

1 reference

12 December 2020

Two processing pathways for the MHC class II-restricted presentation of exogenous influenza virus antigen

1 reference

12 December 2020

Early endosomes and a late endocytic compartment generate different peptide-class II MHC complexes via distinct processing mechanisms.

1 reference

12 December 2020

MHC class II compartments and the kinetics of antigen presentation in activated mouse spleen dendritic cells

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRI3818

1 reference

30 June 2019

Dimensions Publication ID

0 references

1 reference

30 June 2019

PubMed ID

25720354

1 reference

30 June 2019