(Q86393023)

English

A novel double-tracer technique to characterize absorption, distribution, metabolism and excretion (ADME) of [14C]tofogliflozin after oral administration and concomitant intravenous microdose administration of [13C]tofogliflozin in humans

scientific article published on 01 June 2013

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23494983%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

A novel double-tracer technique to characterize absorption, distribution, metabolism and excretion (ADME) of [14C]tofogliflozin after oral administration and concomitant intravenous microdose administration of [13C]tofogliflozin in humans (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23494983%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

author name string

Dietmar Schwab

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23494983%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

Agnes Portron

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23494983%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

Zoe Backholer

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23494983%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

Berthold Lausecker

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23494983%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

Kosuke Kawashima

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23494983%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

publication date

1 June 2013

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23494983%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

Clinical Pharmacokinetics

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23494983%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

52

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23494983%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23494983%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

463-473

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23494983%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

https://scigraph.springernature.com/pub.10.1007/s40262-013-0051-z

0 references

Novel strategies for microdose studies using non-radiolabeled compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/23494983

12 December 2020

based on heuristic

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Inhibition of renal glucose reabsorption: a novel strategy for achieving glucose control in type 2 diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/23494983

12 December 2020

based on heuristic

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A formula to estimate the approximate surface area if height and weight be known. 1916.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23494983

12 December 2020

based on heuristic

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The utility of microdosing over the past 5 years

1 reference

https://pubmed.ncbi.nlm.nih.gov/23494983

12 December 2020

based on heuristic

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Use of microdosing to predict pharmacokinetics at the therapeutic dose: experience with 5 drugs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23494983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calculation and mitigation of isotopic interferences in liquid chromatography-mass spectrometry/mass spectrometry assays and its application in supporting microdose absolute bioavailability studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/23494983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SGLT2 inhibition--a novel strategy for diabetes treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/23494983

12 December 2020

based on heuristic

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Assessing kidney function--measured and estimated glomerular filtration rate

1 reference

https://pubmed.ncbi.nlm.nih.gov/23494983

12 December 2020

based on heuristic

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Unexplored pharmacokinetic opportunities with microdosing in oncology

1 reference

https://pubmed.ncbi.nlm.nih.gov/23494983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose transport by human renal Na+/D-glucose cotransporters SGLT1 and SGLT2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23494983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microdose study of 14C-acetaminophen with accelerator mass spectrometry to examine pharmacokinetics of parent drug and metabolites in healthy subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/23494983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modeling and predicting drug pharmacokinetics in patients with renal impairment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23494983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel and selective sodium-glucose cotransporter-2 inhibitor, tofogliflozin, improves glycaemic control and lowers body weight in patients with type 2 diabetes mellitus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23494983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of the impact of renal impairment on systemic exposure of new molecular entities: evaluation of recent new drug applications

1 reference

https://pubmed.ncbi.nlm.nih.gov/23494983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of fexofenadine: evaluation of a microdose and assessment of absolute oral bioavailability

1 reference

https://pubmed.ncbi.nlm.nih.gov/23494983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Concurrent intravenous administration of a labeled tracer to determine the oral bioavailability of a drug exhibiting Michaelis-Menten metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/23494983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The application of accelerator mass spectrometry to absolute bioavailability studies in humans: simultaneous administration of an intravenous microdose of 14C-nelfinavir mesylate solution and oral nelfinavir to healthy volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/23494983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microdosing assessment to evaluate pharmacokinetics and drug metabolism in rats using liquid chromatography-tandem mass spectrometry.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23494983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effective use of microdosing and Positron Emission Tomography (PET) studies on new drug discovery and development.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23494983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tofogliflozin, a potent and highly specific sodium/glucose cotransporter 2 inhibitor, improves glycemic control in diabetic rats and mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23494983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

What is the objective of the mass balance study? A retrospective analysis of data in animal and human excretion studies employing radiolabeled drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/23494983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Renal sodium-glucose transport: role in diabetes mellitus and potential clinical implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/23494983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The use of isotopes in the determination of absolute bioavailability of drugs in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/23494983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human radiolabeled mass balance studies: objectives, utilities and limitations

1 reference

https://pubmed.ncbi.nlm.nih.gov/23494983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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