(Q86567018)

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Valproic acid-induced hepatotoxicity in Alpers syndrome is associated with mitochondrial permeability transition pore opening-dependent apoptotic sensitivity in an induced pluripotent stem cell model

scientific article published on 10 March 2015

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28 February 2020

Valproic acid-induced hepatotoxicity in Alpers syndrome is associated with mitochondrial permeability transition pore opening-dependent apoptotic sensitivity in an induced pluripotent stem cell model (English)

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28 February 2020

apoptotic process

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28 February 2020

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Duanqing Pei

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28 February 2020

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Shengbiao Li

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28 February 2020

Jingyi Guo

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28 February 2020

Zhongfu Ying

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28 February 2020

Shen Chen

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28 February 2020

Liang Yang

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28 February 2020

Keshi Chen

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28 February 2020

Dajiang Qin

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28 February 2020

Xingguo Liu

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28 February 2020

publication date

10 March 2015

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28 February 2020

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28 February 2020

61

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28 February 2020

5

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28 February 2020

1730-1739

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28 February 2020

Mitochondrial hepatopathies: advances in genetics, therapeutic approaches, and outcomes

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

based on heuristic

inferred from DOI database lookup

Mitochondrial hepatopathies: advances in genetics and pathogenesis

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

based on heuristic

inferred from DOI database lookup

Mitochondrial DNA replication and disease: insights from DNA polymerase γ mutations

1 reference

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7 January 2021

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Alpers syndrome with mutations in POLG: clinical and investigative features.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular diagnosis of Alpers syndrome.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

based on heuristic

inferred from DOI database lookup

Morphological correlates of mitochondrial dysfunction in children

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Features of cell death in brain and liver, the target tissues of progressive neuronal degeneration of childhood with liver disease (Alpers-Huttenlocher disease).

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

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Progressive cerebral poliodystrophy--Alpers' disease. Disorganized giant neuronal mitochondria on electron microscopy

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

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Molecular and biochemical characterisation of a novel mutation in POLG associated with Alpers syndrome

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

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inferred from DOI database lookup

Adverse drug reactions induced by valproic acid

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

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Valproate-induced liver failure in one of two siblings with Alpers disease

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

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POLG DNA testing as an emerging standard of care before instituting valproic acid therapy for pediatric seizure disorders

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

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155th ENMC workshop: polymerase gamma and disorders of mitochondrial DNA synthesis, 21-23 September 2007, Naarden, The Netherlands

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

based on heuristic

inferred from DOI database lookup

Polymerase γ gene POLG determines the risk of sodium valproate-induced liver toxicity

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

based on heuristic

inferred from DOI database lookup

Mitochondrial toxicity of antiepileptic drugs and their tolerability in mitochondrial disorders.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

based on heuristic

inferred from DOI database lookup

Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

based on heuristic

inferred from DOI database lookup

Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

based on heuristic

inferred from DOI database lookup

Premature ageing in mice expressing defective mitochondrial DNA polymerase

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

based on heuristic

inferred from DOI database lookup

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

based on heuristic

inferred from DOI database lookup

Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

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Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

based on heuristic

inferred from DOI database lookup

JD induced pluripotent stem cell-derived hepatocytes faithfully recapitulate the pathophysiology of familial hypercholesterolemia

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

based on heuristic

inferred from DOI database lookup

Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

based on heuristic

inferred from DOI database lookup

POLG exon 22 skipping induced by different mechanisms in two unrelated cases of Alpers syndrome

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

based on heuristic

inferred from DOI database lookup

Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

based on heuristic

inferred from DOI database lookup

OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

based on heuristic

inferred from DOI database lookup

Alpers syndrome: an unusual etiology of failure to thrive

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

based on heuristic

inferred from DOI database lookup

Mitochondria-ros crosstalk in the control of cell death and aging

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

based on heuristic

inferred from DOI database lookup

Superoxide flashes in single mitochondria

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

based on heuristic

inferred from DOI database lookup

Superoxide flashes: early mitochondrial signals for oxidative stress-induced apoptosis

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

based on heuristic

inferred from DOI database lookup

Dimers of mitochondrial ATP synthase form the permeability transition pore

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

based on heuristic

inferred from DOI database lookup

Valproate (VPA) metabolites in various clinical conditions of probable VPA-associated hepatotoxicity.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of L-carnitine treatment for valproate-induced hepatotoxicity

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

based on heuristic

inferred from DOI database lookup

Severe hepatotoxicity during valproate therapy: an update and report of eight new fatalities.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

based on heuristic

inferred from DOI database lookup

A case of valproate-associated hepatotoxicity treated with L-carnitine

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of L-carnitine treatment for valproate-induced hepatotoxicity

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

based on heuristic

inferred from DOI database lookup

Carnitine in the treatment of valproic acid-induced toxicity

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

based on heuristic

inferred from DOI database lookup

Valproic acid I: time course of lipid peroxidation biomarkers, liver toxicity, and valproic acid metabolite levels in rats

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

based on heuristic

inferred from DOI database lookup

N-acetylcysteine prevents the geldanamycin cytotoxicity by forming geldanamycin-N-acetylcysteine adduct

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibiting mitochondrial permeability transition pore opening at reperfusion protects against ischaemia-reperfusion injury

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

based on heuristic

inferred from DOI database lookup

Tissue protection mediated by mitochondrial K+ channels.

1 reference

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7 January 2021

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inferred from DOI database lookup

New aspects for the treatment of cardiac diseases based on the diversity of functional controls on cardiac muscles: mitochondrial ion channels and cardioprotection

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Nicorandil prevents oxidative stress-induced apoptosis in neurons by activating mitochondrial ATP-sensitive potassium channels

1 reference

https://api.crossref.org/works/10.1002%2FHEP.27712

7 January 2021

based on heuristic

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Cardiac mitochondrial preconditioning by Big Ca2+-sensitive K+ channel opening requires superoxide radical generation

1 reference

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7 January 2021

based on heuristic

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Identifiers

10.1002/HEP.27712

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25605636%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

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28 February 2020

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