(Q87418047)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23045279%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

title

β-Catenin signaling dosage dictates tissue-specific tumor predisposition in Apc-driven cancer (English)

1 reference

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10 March 2020

2

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10 March 2020

author name string

E R M Bakker

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23045279%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

P F Franken

3

1 reference

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10 March 2020

W Helvensteijn

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23045279%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

C H M van Deurzen

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23045279%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

W van Veelen

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23045279%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

E J Kuipers

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23045279%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

R Smits

8

1 reference

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10 March 2020

publication date

8 October 2012

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10 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23045279%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

volume

32

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23045279%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

issue

38

1 reference

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10 March 2020

page(s)

4579-4585

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Wnt signalling in stem cells and cancer

10 March 2020

cites work

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.449

The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.449

The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.449

Refining the relation between 'first hits' and 'second hits' at the APC locus: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.449

Somatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.449

A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.449

Colorectal cancers show distinct mutation spectra in members of the canonical WNT signaling pathway according to their anatomical location and type of genetic instability

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.449

Key signaling nodes in mammary gland development and cancer: β-catenin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.449

Apc1638N: a mouse model for familial adenomatous polyposis-associated desmoid tumors and cutaneous cysts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.449

A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.449

Mutations in the APC tumour suppressor gene cause chromosomal instability

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.449

Cytoskeleton out of the cupboard: colon cancer and cytoskeletal changes induced by loss of APC.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.449

A two-step model for colon adenoma initiation and progression caused by APC loss

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.449

APC mutations in colorectal tumours from FAP patients are selected for CtBP-mediated oligomerization of truncated APC.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.449

The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.449

A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.449

beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.449

Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.449

APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.449

Loss of Apc and the entire chromosome 18 but absence of mutations at the Ras and Tp53 genes in intestinal tumors from Apc1638N, a mouse model for Apc-driven carcinogenesis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.449

Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.449

Oncogenic KRAS is not necessary for Wnt signalling activation in APC-associated FAP adenomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.449

Nuclear beta-catenin expression and Wnt signalling: in defence of the dogma.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.449

A Robertsonian translocation suppresses a somatic recombination pathway to loss of heterozygosity.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.449

Distinct thresholds govern Myc's biological output in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.449

Myc heterozygosity attenuates the phenotypes of APC deficiency in the small intestine.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.449

Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.449

Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.449

The C-terminus of Apc does not influence intestinal adenoma development or progression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.449

β-catenin tyrosine 654 phosphorylation increases Wnt signalling and intestinal tumorigenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.449

31 March 2020

Identifiers

DOI

10.1038/ONC.2012.449

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23045279%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

1 reference