(Q87460136)

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Trigonelline and diosgenin attenuate ER stress, oxidative stress-mediated damage in pancreas and enhance adipose tissue PPARγ activity in type 2 diabetic rats

scientific article published on 29 July 2014

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Europe PubMed Central

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10 March 2020

Trigonelline and diosgenin attenuate ER stress, oxidative stress-mediated damage in pancreas and enhance adipose tissue PPARγ activity in type 2 diabetic rats (English)

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Europe PubMed Central

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10 March 2020

Sadras Sudha Rani

6

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10 March 2020

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M Tharaheswari

1

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10 March 2020

N Jayachandra Reddy

2

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10 March 2020

R Kumar

3

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10 March 2020

K C Varshney

4

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10 March 2020

M Kannan

5

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10 March 2020

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29 July 2014

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10 March 2020

Molecular and Cellular Biochemistry

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10 March 2020

396

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10 March 2020

1-2

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10 March 2020

161-174

1 reference

Europe PubMed Central

PubMed publication ID

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10 March 2020

Peroxisome proliferator-activated receptors: nuclear control of metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessing the predictive accuracy of QUICKI as a surrogate index for insulin sensitivity using a calibration model

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of endoplasmic reticulum stress in insulin resistance and diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adipokines: the missing link between insulin resistance and obesity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetaminophen induces ER dependent signaling in mouse liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role for endoplasmic reticulum stress in diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selenium: Biochemical Role as a Component of Glutathione Peroxidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of prolyl hydroxylase domain protein (PHD) during rosiglitazone-induced adipocyte differentiation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thiazolidinediones

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leptin Levels in Type 2 Diabetes: Associations with Measures of Insulin Resistance and Insulin Secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoplasmic reticulum stress and the inflammatory basis of metabolic disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum leptin, adiponectin and tumor necrosis factor-α in hyperlipidemic rats with/without concomitant diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumour necrosis factor alpha: a key regulator of adipose tissue mass

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoglycemic effects of steroidal sapogenins isolated from Jamaican bitter yam, Dioscorea polygonoides

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cross-talk between two apoptotic pathways activated by endoplasmic reticulum stress: differential contribution of caspase-12 and AIF.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improved Treatment of Ligands and Coupling Effects in Empirical Calculation and Rationalization of pKa Values.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coupling endoplasmic reticulum stress to the cell death program

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integration of metabolism and inflammation by lipid-activated nuclear receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Actions of PPARgamma agonism on adipose tissue remodeling, insulin sensitivity, and lipemia in absence of glucocorticoids.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antioxidant status of streptozotocin diabetic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPARgamma-mediated insulin sensitization: the importance of fat versus muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An easy colorimetric micromethod for routine determination of free fatty acids in plasma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-diabetic effect of trigonelline and nicotinic acid, on KK-A(y) mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha)

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms linking obesity to insulin resistance and type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoplasmic reticulum stress, pancreatic β-cell degeneration, and diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Experimental diabetes treated with trigonelline: effect on β cell and pancreatic oxidative parameters

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Repeatability characteristics of simple indices of insulin resistance: implications for research applications

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) and its coactivators steroid receptor coactivator-1 and PPAR-binding protein PBP in the brown fat, urinary bladder, colon, and breast of the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Obesity and diabetes in the developing world--a growing challenge

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of obesity-associated insulin resistance: many choices on the menu

1 reference

https://pubmed.ncbi.nlm.nih.gov/25070833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11010-014-2152-X

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25070833%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25070833%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

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