(Q87870332)

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Topical rather than intradermal application of the TLR7 ligand imiquimod leads to human dermal dendritic cell maturation and CD8+ T-cell cross-priming

scientific article published on 24 June 2014

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scholarly article

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18 March 2020

Topical rather than intradermal application of the TLR7 ligand imiquimod leads to human dermal dendritic cell maturation and CD8+ T-cell cross-priming (English)

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18 March 2020

dermal dendritic cell

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author name string

Cynthia M Fehres

1

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18 March 2020

Sven C M Bruijns

2

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18 March 2020

Astrid J van Beelen

3

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18 March 2020

Hakan Kalay

4

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18 March 2020

Martino Ambrosini

5

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18 March 2020

Wendy W J Unger

7

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18 March 2020

Yvette van Kooyk

9

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18 March 2020

publication date

24 June 2014

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18 March 2020

European Journal of Immunology

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18 March 2020

44

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18 March 2020

8

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18 March 2020

2415-2424

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18 March 2020

The use of TLR7 and TLR8 ligands for the enhancement of cancer immunotherapy

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Adjuvants for human vaccines

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Use of defined TLR ligands as adjuvants within human vaccines.

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Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

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Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

1 reference

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Oligodeoxynucleotides differentially modulate activation of TLR7 and TLR8 by imidazoquinolines

1 reference

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7 January 2021

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Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets

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Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides

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7 January 2021

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TLR7 triggering with polyuridylic acid promotes cross-presentation in CD8α+ conventional dendritic cells by enhancing antigen preservation and MHC class I antigen permanence on the dendritic cell surface

1 reference

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7 January 2021

based on heuristic

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Triggering TLR7 in mice induces immune activation and lymphoid system disruption, resembling HIV-mediated pathology.

1 reference

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7 January 2021

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Treatment of stage IA cutaneous T-Cell lymphoma with topical application of the immune response modifier imiquimod

1 reference

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7 January 2021

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Topical imiquimod has therapeutic and immunomodulatory effects against intracranial tumors

1 reference

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7 January 2021

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Professional antigen-presenting cells of the skin

1 reference

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7 January 2021

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Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells

1 reference

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7 January 2021

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Understanding human myeloid dendritic cell subsets for the rational design of novel vaccines

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7 January 2021

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Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse CD103+ nonlymphoid dendritic cells

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344094

7 January 2021

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Characterization of resident and migratory dendritic cells in human lymph nodes

1 reference

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7 January 2021

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IL-10 conditioning of human skin affects the distribution of migratory dendritic cell subsets and functional T cell differentiation.

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7 January 2021

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The differential production of cytokines by human Langerhans cells and dermal CD14(+) DCs controls CTL priming

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7 January 2021

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IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses

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7 January 2021

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Inducing antitumor T cell immunity: comparative functional analysis of interstitial versus Langerhans dendritic cells in a human cell line model.

1 reference

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7 January 2021

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CD14+ antigen-presenting cells in human dermis are less mature than their CD1a+ counterparts

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344094

7 January 2021

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Loss of TLR2, TLR4, and TLR5 on Langerhans cells abolishes bacterial recognition

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344094

7 January 2021

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Intradermal delivery of TLR agonists in a human explant skin model: preferential activation of migratory dendritic cells by polyribosinic-polyribocytidylic acid and peptidoglycans.

1 reference

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7 January 2021

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A postmigrational switch among skin-derived dendritic cells to a macrophage-like phenotype is predetermined by the intracutaneous cytokine balance.

1 reference

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7 January 2021

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Immunization of malignant melanoma patients with full-length NY-ESO-1 protein using TLR7 agonist imiquimod as vaccine adjuvant

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IL-17 and IL-22 enhance skin inflammation by stimulating the secretion of IL-1β by keratinocytes via the ROS-NLRP3-caspase-1 pathway

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Characteristics and regulation of the expression on interleukin 1 receptors by murine Langerhans cells and keratinocytes

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The ophthalmic side-effects of imiquimod therapy in the management of periocular skin lesions

1 reference

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7 January 2021

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Imiquimod 5% cream use in dermatology, side effects and recent patents

1 reference

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7 January 2021

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Imiquimod 5% cream monotherapy for cutaneous squamous cell carcinoma in situ (Bowen's disease): A randomized, double-blind, placebo-controlled trial

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Aldara activates TLR7-independent immune defence

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CD27 is required for generation and long-term maintenance of T cell immunity

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A subset of dendritic cells induces CD4+ T cells to produce IFN-gamma by an IL-12-independent but CD70-dependent mechanism in vivo.

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Molecular mechanism and function of CD40/CD40L engagement in the immune system.

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Prolonged maturation and enhanced transduction of dendritic cells migrated from human skin explants after in situ delivery of CD40-targeted adenoviral vectors

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Differential regulation of C-type lectin expression on tolerogenic dendritic cell subsets.

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Identifiers

10.1002/EJI.201344094

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24825342%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24825342%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

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