(Q87870332)

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Topical rather than intradermal application of the TLR7 ligand imiquimod leads to human dermal dendritic cell maturation and CD8+ T-cell cross-priming

scientific article published on 24 June 2014

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18 March 2020

Topical rather than intradermal application of the TLR7 ligand imiquimod leads to human dermal dendritic cell maturation and CD8+ T-cell cross-priming (English)

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18 March 2020

dermal dendritic cell

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author name string

Cynthia M Fehres

1

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18 March 2020

Sven C M Bruijns

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18 March 2020

Astrid J van Beelen

3

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18 March 2020

Hakan Kalay

4

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18 March 2020

Martino Ambrosini

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18 March 2020

Wendy W J Unger

7

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18 March 2020

Yvette van Kooyk

9

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18 March 2020

publication date

24 June 2014

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18 March 2020

European Journal of Immunology

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18 March 2020

44

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18 March 2020

8

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18 March 2020

2415-2424

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18 March 2020

The use of TLR7 and TLR8 ligands for the enhancement of cancer immunotherapy

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Oligodeoxynucleotides differentially modulate activation of TLR7 and TLR8 by imidazoquinolines

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Triggering TLR7 in mice induces immune activation and lymphoid system disruption, resembling HIV-mediated pathology.

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Treatment of stage IA cutaneous T-Cell lymphoma with topical application of the immune response modifier imiquimod

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Topical imiquimod has therapeutic and immunomodulatory effects against intracranial tumors

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Professional antigen-presenting cells of the skin

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Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells

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Understanding human myeloid dendritic cell subsets for the rational design of novel vaccines

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Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse CD103+ nonlymphoid dendritic cells

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IL-10 conditioning of human skin affects the distribution of migratory dendritic cell subsets and functional T cell differentiation.

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The differential production of cytokines by human Langerhans cells and dermal CD14(+) DCs controls CTL priming

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IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses

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Inducing antitumor T cell immunity: comparative functional analysis of interstitial versus Langerhans dendritic cells in a human cell line model.

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7 January 2021

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CD14+ antigen-presenting cells in human dermis are less mature than their CD1a+ counterparts

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7 January 2021

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Loss of TLR2, TLR4, and TLR5 on Langerhans cells abolishes bacterial recognition

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Intradermal delivery of TLR agonists in a human explant skin model: preferential activation of migratory dendritic cells by polyribosinic-polyribocytidylic acid and peptidoglycans.

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A postmigrational switch among skin-derived dendritic cells to a macrophage-like phenotype is predetermined by the intracutaneous cytokine balance.

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Immunization of malignant melanoma patients with full-length NY-ESO-1 protein using TLR7 agonist imiquimod as vaccine adjuvant

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IL-17 and IL-22 enhance skin inflammation by stimulating the secretion of IL-1β by keratinocytes via the ROS-NLRP3-caspase-1 pathway

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The ophthalmic side-effects of imiquimod therapy in the management of periocular skin lesions

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CD27 is required for generation and long-term maintenance of T cell immunity

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Identifiers

10.1002/EJI.201344094

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24825342%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24825342%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

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