(Q88588446)

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25 March 2020

title

Tau reduction in the presence of amyloid-β prevents tau pathology and neuronal death in vivo (English)

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25 March 2020

4

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25 March 2020

15

Matthew P Frosch

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25 March 2020

17

Bradley T Hyman

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25 March 2020

author name string

Sarah L DeVos

1

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25 March 2020

Bianca T Corjuc

2

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25 March 2020

Caitlin Commins

3

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25 March 2020

Riley N Bannon

5

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25 March 2020

Diana Corjuc

6

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25 March 2020

Benjamin D Moore

7

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25 March 2020

Rachel E Bennett

8

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25 March 2020

Mehdi Jorfi

9

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25 March 2020

Jose A Gonzales

10

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25 March 2020

Patrick M Dooley

11

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25 March 2020

Allyson D Roe

12

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25 March 2020

Rose Pitstick

13

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25 March 2020

Daniel Irimia

14

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25 March 2020

George A Carlson

16

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25 March 2020

publication date

1 July 2018

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25 March 2020

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25 March 2020

volume

141

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25 March 2020

issue

7

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25 March 2020

page(s)

2194-2212

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describes a project that uses

25 March 2020

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6022692/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer's disease

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

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Alzheimer's disease: cell-specific pathology isolates the hippocampal formation

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Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205.

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12 December 2020

Molecular basis of phenotypic variability in sporadic Creutzfeldt-Jakob disease

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12 December 2020

Control of memory formation through regulated expression of a CaMKII transgene

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12 December 2020

Full-length amyloid-beta (1-42(43)) and amino-terminally modified and truncated amyloid-beta 42(43) deposit in diffuse plaques.

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12 December 2020

Bilateral injections of amyloid-beta 25-35 into the amygdala of young Fischer rats: behavioral, neurochemical, and time dependent histopathological effects

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12 December 2020

Tangles and plaques in nondemented aging and "preclinical" Alzheimer's disease.

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12 December 2020

Comparative biochemistry of tau in progressive supranuclear palsy, corticobasal degeneration, FTDP-17 and Pick's disease

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12 December 2020

Co-expression of multiple transgenes in mouse CNS: a comparison of strategies.

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12 December 2020

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

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12 December 2020

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

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12 December 2020

Biochemical characterization of the core structure of alpha-synuclein filaments

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12 December 2020

Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer's disease.

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12 December 2020

Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase

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12 December 2020

Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain

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12 December 2020

Associations of cortical astrogliosis with cognitive performance and dementia status

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12 December 2020

Tau suppression in a neurodegenerative mouse model improves memory function

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12 December 2020

Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice.

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12 December 2020

Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy

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12 December 2020

Evidence for synaptic stripping by cortical microglia.

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12 December 2020

Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

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12 December 2020

Quantification of the rat spinal microglial response to peripheral nerve injury as revealed by immunohistochemical image analysis and flow cytometry

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12 December 2020

Insights into prion strains and neurotoxicity

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12 December 2020

Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice

1 reference

12 December 2020

Screening for amyloid aggregation by Semi-Denaturing Detergent-Agarose Gel Electrophoresis

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12 December 2020

Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models

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12 December 2020

A{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model

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12 December 2020

Tau reduction prevents Abeta-induced defects in axonal transport.

1 reference

12 December 2020

Amyloid β accelerates phosphorylation of tau and neurofibrillary tangle formation in an amyloid precursor protein and tau double-transgenic mouse model

1 reference

12 December 2020

Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease.

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12 December 2020

Tau transgenic mice as models for cerebrospinal fluid tau biomarkers.

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12 December 2020

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export.

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12 December 2020

Frontotemporal dementia: implications for understanding Alzheimer disease

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12 December 2020

Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature

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12 December 2020

Sensitive quantitative assays for tau and phospho-tau in transgenic mouse models

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12 December 2020

Lipopolysaccharide-induced microglial activation and neuroprotection against experimental brain injury is independent of hematogenous TLR4

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12 December 2020

Lack of tau proteins rescues neuronal cell death and decreases amyloidogenic processing of APP in APP/PS1 mice.

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12 December 2020

Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease.

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12 December 2020

Age-appropriate cognition and subtle dopamine-independent motor deficits in aged tau knockout mice

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12 December 2020

Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β

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12 December 2020

The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through Tau phosphorylation

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12 December 2020

A phenotypic change but not proliferation underlies glial responses in Alzheimer disease

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12 December 2020

Distinct α-synuclein strains differentially promote tau inclusions in neurons

1 reference

12 December 2020

Antisense reduction of tau in adult mice protects against seizures

1 reference

12 December 2020

Reversal of neurofibrillary tangles and tau-associated phenotype in the rTgTauEC model of early Alzheimer's disease

1 reference

12 December 2020

Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo.

1 reference

12 December 2020

Increased misfolding and truncation of tau in APP/PS1/tau transgenic mice compared to mutant tau mice

1 reference

12 December 2020

Distinct tau prion strains propagate in cells and mice and define different tauopathies

1 reference

12 December 2020

Seizure resistance without parkinsonism in aged mice after tau reduction

1 reference

12 December 2020

Proteopathic tau seeding predicts tauopathy in vivo.

1 reference

12 December 2020

Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates.

1 reference

12 December 2020

Conformation determines the seeding potencies of native and recombinant Tau aggregates

1 reference

12 December 2020

Tau silencing by siRNA in the P301S mouse model of tauopathy

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12 December 2020

Immune attack: the role of inflammation in Alzheimer disease.

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12 December 2020

Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain

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12 December 2020

Tau Protein Quantification in Human Cerebrospinal Fluid by Targeted Mass Spectrometry at High Sequence Coverage Provides Insights into Its Primary Structure Heterogeneity.

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12 December 2020

α-Synuclein and huntingtin exon 1 amyloid fibrils bind laterally to the cellular membrane

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12 December 2020

Imaging the accumulation and suppression of tau pathology using multiparametric MRI.

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12 December 2020

Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients

1 reference

12 December 2020

Beta-amyloid 1-42 monomers, but not oligomers, produce PHF-like conformation of Tau protein

1 reference

12 December 2020

No Overt Deficits in Aged Tau-Deficient C57Bl/6.Mapttm1(EGFP)Kit GFP Knockin Mice

1 reference

12 December 2020

Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy.

1 reference

12 December 2020

Amplification of distinct α-synuclein fibril conformers through protein misfolding cyclic amplification.

1 reference

12 December 2020

Comparison of In Vivo and Ex Vivo MRI for the Detection of Structural Abnormalities in a Mouse Model of Tauopathy

1 reference

12 December 2020

Enhanced Tau Aggregation in the Presence of Amyloid β.

1 reference

12 December 2020

Tracking progressive pathological and functional decline in the rTg4510 mouse model of tauopathy.

1 reference

12 December 2020

Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain

1 reference

12 December 2020

Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation

1 reference

12 December 2020

Identifiers

DOI

10.1093/BRAIN/AWY117

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29733334%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

1 reference

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25 March 2020

PubMed publication ID

29733334

1 reference