(Q88683268)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29764852%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

title

Combined HDAC and Bromodomain Protein Inhibition Reprograms Tumor Cell Metabolism and Elicits Synthetic Lethality in Glioblastoma (English)

1 reference

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26 March 2020

1 reference

3

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26 March 2020

Giulio Kleiner

8

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26 March 2020

Maria J Sanchez-Quintero

9

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26 March 2020

Mike-Andrew Westhoff

11

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26 March 2020

author name string

Yiru Zhang

1

1 reference

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26 March 2020

Chiaki Tsuge Ishida

2

1 reference

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26 March 2020

Sheng-Fu L Lo

4

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26 March 2020

Junfei Zhao

5

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26 March 2020

Chang Shu

6

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26 March 2020

Elena Bianchetti

7

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26 March 2020

Catarina M Quinzii

10

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26 March 2020

Georg Karpel-Massler

12

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26 March 2020

Peter Canoll

13

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26 March 2020

Markus D Siegelin

14

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26 March 2020

publication date

15 May 2018

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26 March 2020

published in

Clinical Cancer Research

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26 March 2020

volume

24

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26 March 2020

issue

16

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26 March 2020

page(s)

3941-3954

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Use of an orthotopic xenograft model for assessing the effect of epidermal growth factor receptor amplification on glioblastoma radiation response.

26 March 2020

cites work

1 reference

12 December 2020

The PERK/eIF2alpha/ATF4 module of the UPR in hypoxia resistance and tumor growth

1 reference

12 December 2020

An integrated genomic analysis of human glioblastoma multiforme

1 reference

12 December 2020

Analysis of the IDH1 codon 132 mutation in brain tumors

1 reference

12 December 2020

c-Myc is required for maintenance of glioma cancer stem cells

1 reference

12 December 2020

IDH1 and IDH2 mutations in gliomas

1 reference

12 December 2020

Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

1 reference

12 December 2020

A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications

1 reference

12 December 2020

An ERK-dependent pathway to Noxa expression regulates apoptosis by platinum-based chemotherapeutic drugs.

1 reference

12 December 2020

Phosphorylation regulates c-Myc's oncogenic activity in the mammary gland.

1 reference

12 December 2020

Targeting MYC dependence in cancer by inhibiting BET bromodomains

1 reference

12 December 2020

Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death

1 reference

12 December 2020

Regulation of c-Myc Protein Abundance by a Protein Phosphatase 2A-Glycogen Synthase Kinase 3β-Negative Feedback Pathway

1 reference

12 December 2020

Oncolytic measles virus strains have significant antitumor activity against glioma stem cells

1 reference

12 December 2020

D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function

1 reference

12 December 2020

PI3K and Bcl-2 inhibition primes glioblastoma cells to apoptosis through downregulation of Mcl-1 and Phospho-BAD.

1 reference

12 December 2020

Inhibition of protein phosphatase 2A (PP2A) prevents Mcl-1 protein dephosphorylation at the Thr-163/Ser-159 phosphodegron, dramatically reducing expression in Mcl-1-amplified lymphoma cells

1 reference

12 December 2020

A Bim-targeting strategy overcomes adaptive bortezomib resistance in myeloma through a novel link between autophagy and apoptosis

1 reference

12 December 2020

Genetic and Pharmacological Screens Converge in Identifying FLIP, BCL2, and IAP Proteins as Key Regulators of Sensitivity to the TRAIL-Inducing Anticancer Agent ONC201/TIC10.

1 reference

12 December 2020

Toward precision medicine in glioblastoma: the promise and the challenges

1 reference

12 December 2020

ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis.

1 reference

12 December 2020

2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling

1 reference

12 December 2020

Sorafenib Sensitizes Glioma Cells to the BH3 Mimetic ABT-737 by Targeting MCL1 in a STAT3-Dependent Manner

1 reference

12 December 2020

Efficacy of PARP Inhibitor Rucaparib in Orthotopic Glioblastoma Xenografts Is Limited by Ineffective Drug Penetration into the Central Nervous System.

1 reference

12 December 2020

Sorafenib Inhibition of Mcl-1 Accelerates ATRA-Induced Apoptosis in Differentiation-Responsive AML Cells

1 reference

12 December 2020

TIC10/ONC201 synergizes with Bcl-2/Bcl-xL inhibition in glioblastoma by suppression of Mcl-1 and its binding partners in vitro and in vivo

1 reference

12 December 2020

Delineation of MGMT Hypermethylation as a Biomarker for Veliparib-Mediated Temozolomide-Sensitizing Therapy of Glioblastoma

1 reference

12 December 2020

Single-Cell Phosphoproteomics Resolves Adaptive Signaling Dynamics and Informs Targeted Combination Therapy in Glioblastoma

1 reference

12 December 2020

A Synthetic Cell-Penetrating Dominant-Negative ATF5 Peptide Exerts Anticancer Activity against a Broad Spectrum of Treatment-Resistant Cancers

1 reference

12 December 2020

Metabolic reprogramming of glioblastoma cells by L-asparaginase sensitizes for apoptosis in vitro and in vivo

1 reference

12 December 2020

FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation.

1 reference

12 December 2020

Dual modulation of MCL-1 and mTOR determines the response to sunitinib

1 reference

12 December 2020

Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizing FBXL14-mediated Myc ubiquitination

1 reference

12 December 2020

Advances in epigenetic glioblastoma therapy

1 reference

12 December 2020

Mitochondrial matrix chaperone and c-myc inhibition causes enhanced lethality in glioblastoma.

1 reference

12 December 2020

BH3-mimetics and BET-inhibitors elicit enhanced lethality in malignant glioma.

1 reference

12 December 2020

Transcriptional Dependencies in Diffuse Intrinsic Pontine Glioma

1 reference

12 December 2020

Inhibition of Mitochondrial Matrix Chaperones and Antiapoptotic Bcl-2 Family Proteins Empower Antitumor Therapeutic Responses

1 reference

12 December 2020

Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC.

1 reference

12 December 2020

Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development

1 reference

12 December 2020

Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL.

1 reference

12 December 2020

Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy

1 reference

12 December 2020

10.1158/1078-0432.CCR-18-0260

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29764852%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

1 reference

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26 March 2020

PubMed publication ID

29764852

1 reference