(Q90400018)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31572196%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

review article

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title

Rescue of Noradrenergic System as a Novel Pharmacological Strategy in the Treatment of Chronic Pain: Focus on Microglia Activation (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31572196%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

1 reference

1 reference

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31572196%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

Giuseppe Caruso

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31572196%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

3

Filippo Drago

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31572196%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

6

Maria Angela Sortino

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31572196%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

author name string

Sara Merlo

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31572196%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

Carmela Parenti

series ordinal

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31572196%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

publication date

12 September 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31572196%20AND%20SRC:MED&resulttype=core&format=json

Frontiers in Pharmacology

13 April 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31572196%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

volume

10

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31572196%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

page(s)

1024

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31572196%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

13 April 2020

copyright license

start time

12 September 2019

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Release of neurotransmitters in the locus coeruleus.

1 reference

12 December 2020

Norepinephrine facilitates inhibitory transmission in substantia gelatinosa of adult rat spinal cord (part 1): effects on axon terminals of GABAergic and glycinergic neurons

1 reference

12 December 2020

Descending control of pain

1 reference

12 December 2020

Effects of norepinephrine on rat cultured microglial cells that express alpha1, alpha2, beta1 and beta2 adrenergic receptors

1 reference

12 December 2020

MAPK activation in nociceptive neurons and pain hypersensitivity

1 reference

12 December 2020

Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats

1 reference

12 December 2020

Immunocytochemical localization of beta2-adrenergic receptors in the rat spinal cord and their spatial relationships to tyrosine hydroxylase-immunoreactive terminals

1 reference

12 December 2020

Noradrenergic receptor mRNA expression in adult rat superficial dorsal horn and dorsal root ganglion neurons

1 reference

12 December 2020

BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain

1 reference

12 December 2020

Venlafaxine exhibits an anti-inflammatory effect in an inflammatory co-culture model

1 reference

12 December 2020

Mice lacking central serotonergic neurons show enhanced inflammatory pain and an impaired analgesic response to antidepressant drugs

1 reference

12 December 2020

Brain derived nerve growth factor induces spinal noradrenergic fiber sprouting and enhances clonidine analgesia following nerve injury in rats

1 reference

12 December 2020

Intrathecal polymer-based interleukin-10 gene delivery for neuropathic pain

1 reference

12 December 2020

Activation of dorsal horn microglia contributes to diabetes-induced tactile allodynia via extracellular signal-regulated protein kinase signaling

1 reference

12 December 2020

Spinal glial activation contributes to pathological pain states

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12 December 2020

Intrathecal administration of clonidine attenuates spinal neuroimmune activation in a rat model of neuropathic pain with existing hyperalgesia.

1 reference

12 December 2020

Neuropathic pain: a maladaptive response of the nervous system to damage

1 reference

12 December 2020

Involvement of the Nociceptin/Orphanin FQ-NOP receptor system in the ventrolateral periaqueductal gray following mechanical allodynia in chronic pain.

1 reference

12 December 2020

Noradrenaline reduces the ATP-stimulated phosphorylation of p38 MAP kinase via beta-adrenergic receptors-cAMP-protein kinase A-dependent mechanism in cultured rat spinal microglia.

1 reference

12 December 2020

Noradrenaline induces IL-1ra and IL-1 type II receptor expression in primary glial cells and protects against IL-1beta-induced neurotoxicity

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12 December 2020

Beta2-adrenoceptor agonists alleviate neuropathic allodynia in mice after chronic treatment

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12 December 2020

Spinal alpha 2-adrenoceptor-mediated analgesia in neuropathic pain reflects brain-derived nerve growth factor and changes in spinal cholinergic neuronal function

1 reference

12 December 2020

Evidence for suppression of spinal glial activation by dexmedetomidine in a rat model of monoarthritis

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12 December 2020

Spinal astrocytic activation contributes to mechanical allodynia in a mouse model of type 2 diabetes

1 reference

12 December 2020

Increased presynaptic and postsynaptic α2-adrenoceptor activity in the spinal dorsal horn in painful diabetic neuropathy

1 reference

12 December 2020

The complex role of serotonin and 5-HT receptors in chronic pain

1 reference

12 December 2020

Spatial and temporal activation of spinal glial cells: role of gliopathy in central neuropathic pain following spinal cord injury in rats

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12 December 2020

Transforming growth factor-β in normal nociceptive processing and pathological pain models

1 reference

12 December 2020

Differential adaptive changes on serotonin and noradrenaline transporters in a rat model of peripheral neuropathic pain.

1 reference

12 December 2020

Conditioned pain modulation predicts duloxetine efficacy in painful diabetic neuropathy.

1 reference

12 December 2020

Conditioned pain modulation in populations with chronic pain: a systematic review and meta-analysis

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12 December 2020

The noradrenergic pain regulation system: a potential target for pain therapy

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12 December 2020

Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury

1 reference

12 December 2020

Glia and pain: is chronic pain a gliopathy?

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12 December 2020

Persistent mechanical allodynia positively correlates with an increase in activated microglia and increased P-p38 mitogen-activated protein kinase activation in streptozotocin-induced diabetic rats.

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12 December 2020

Antidepressants suppress neuropathic pain by a peripheral β2-adrenoceptor mediated anti-TNFα mechanism

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12 December 2020

A β1/2 adrenergic receptor-sensitive intracellular signaling pathway modulates CCL2 production in cultured spinal astrocytes.

1 reference

12 December 2020

Impaired noradrenaline homeostasis in rats with painful diabetic neuropathy as a target of duloxetine analgesia

1 reference

12 December 2020

Preventive and alleviative effect of tramadol on neuropathic pain in rats: roles of α₂-adrenoceptors and spinal astrocytes

1 reference

12 December 2020

Activated microglia in the spinal cord underlies diabetic neuropathic pain

1 reference

12 December 2020

Pathological pain and the neuroimmune interface

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12 December 2020

Face-to-face comparison of the predictive validity of two models of neuropathic pain in the rat: analgesic activity of pregabalin, tramadol and duloxetine

1 reference

12 December 2020

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed.

1 reference

12 December 2020

Emerging targets in neuroinflammation-driven chronic pain

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12 December 2020

Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis

1 reference

12 December 2020

A key role for TGF-β1 in hippocampal synaptic plasticity and memory.

1 reference

12 December 2020

Antihyperalgesic effect of duloxetine and amitriptyline in rats after peripheral nerve injury: Influence of descending noradrenergic plasticity.

1 reference

12 December 2020

Impaired Pain-evoked Analgesia after Nerve Injury in Rats Reflects Altered Glutamate Regulation in the Locus Coeruleus

1 reference

12 December 2020

The effect of serotonin-noradrenaline reuptake inhibitor duloxetine on the intervertebral disk-related radiculopathy in rats.

1 reference

12 December 2020

Cytokines in Neuropathic Pain and Associated Depression

1 reference

12 December 2020

Disruption of Spinal Noradrenergic Activation Delays Recovery of Acute Incision-Induced Hypersensitivity and Increases Spinal Glial Activation in the Rat.

1 reference

12 December 2020

Changing paradigm to target microglia in neurodegenerative diseases: from anti-inflammatory strategy to active immunomodulation.

1 reference

12 December 2020

Disease-Induced Neuroinflammation and Depression

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12 December 2020

Noradrenergic Locus Coeruleus pathways in pain modulation.

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12 December 2020

Evaluation of the analgesic effects of ammoxetine, a novel potent serotonin and norepinephrine reuptake inhibitor

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12 December 2020

A polarizing question: do M1 and M2 microglia exist?

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12 December 2020

Repeated activation of delta opiod receptors counteracts nerve injury-induced TNF-α up-regulation in the sciatic nerve of rats with neuropathic pain: A possible correlation with delta opiod receptors-mediated antiallodinic effect

1 reference

12 December 2020

Duloxetine Inhibits Microglial P2X4 Receptor Function and Alleviates Neuropathic Pain after Peripheral Nerve Injury

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12 December 2020

Role of Microglia in Neurological Disorders and Their Potentials as a Therapeutic Target

1 reference

12 December 2020

Stimulation of spinal dorsal horn β2-adrenergic receptor ameliorates neuropathic mechanical hypersensitivity through a reduction of phosphorylation of microglial p38 MAP kinase and astrocytic c-jun N-terminal kinase.

1 reference

12 December 2020

Is tapentadol different from classical opioids? A review of the evidence

1 reference

12 December 2020

Microglia in Physiology and Disease.

1 reference

12 December 2020

From acute to chronic pain: tapentadol in the progressive stages of this disease entity

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12 December 2020

Microglia: Housekeeper of the Central Nervous System.

1 reference

12 December 2020

Chronic Treatment with Fluoxetine Induces Sex-Dependent Analgesic Effects and Modulates HDAC2 and mGlu2 Expression in Female Mice.

1 reference

12 December 2020

Neurobiological links between depression and AD: The role of TGF-β1 signaling as a new pharmacological target.

1 reference

12 December 2020

Neuroprotective effect of duloxetine in a mouse model of diabetic neuropathy: Role of glia suppressing mechanisms

1 reference

12 December 2020

Selective deficiencies in descending inhibitory modulation in neuropathic rats: implications for enhancing noradrenergic tone

1 reference

12 December 2020

Ammoxetine attenuates diabetic neuropathic pain through inhibiting microglial activation and neuroinflammation in the spinal cord.

1 reference

12 December 2020

Perspectives in Pain Research 2014: Neuroinflammation and glial cell activation: The cause of transition from acute to chronic pain?

1 reference

12 December 2020

Does 'Strong Analgesic' Equal 'Strong Opioid'? Tapentadol and the Concept of 'µ-Load'

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12 December 2020

A Dual Noradrenergic Mechanism for the Relief of Neuropathic Allodynia by the Antidepressant Drugs Duloxetine and Amitriptyline.

1 reference

12 December 2020

Tapentadol: an analgesic that differs from classic opioids due to its noradrenergic mechanism of action

1 reference

12 December 2020

Strategies to Treat Chronic Pain and Strengthen Impaired Descending Noradrenergic Inhibitory System

1 reference

12 December 2020

Microglial Modulation as a Target for Chronic Pain: From the Bench to the Bedside and Back

1 reference

12 December 2020

Brain Microglial Activation in Chronic Pain-Associated Affective Disorder

1 reference

12 December 2020

Duloxetine, a Balanced Serotonin-Norepinephrine Reuptake Inhibitor, Improves Painful Chemotherapy-Induced Peripheral Neuropathy by Inhibiting Activation of p38 MAPK and NF-κB

1 reference

12 December 2020

Simultaneous Activation of Mu and Delta Opioid Receptors Reduces Allodynia and Astrocytic Connexin 43 in an Animal Model of Neuropathic Pain

1 reference

12 December 2020

Sphingosine-1-phosphate receptor 1 activation in astrocytes contributes to neuropathic pain

1 reference

12 December 2020

Identifiers

DOI

10.3389/FPHAR.2019.01024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31572196%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31572196%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

1 reference