(Q106518963)

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RAC1 binds effectors at the plasma membrane

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-9013145)

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8 July 2022

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8 July 2022

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8 July 2022

https://identifiers.org/reactome:R-HSA-9013145

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8 July 2022

RAC1 effectors [cytosol]

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8 July 2022

RAC1:GTP [plasma membrane]

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8 July 2022

RAC1:GTP:RAC1 effectors [plasma membrane]

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8 July 2022

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

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8 July 2022

Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family

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8 July 2022

Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1

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8 July 2022

Nox1-dependent reactive oxygen generation is regulated by Rac1

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8 July 2022

Identification of a conserved Rac-binding site on NADPH oxidases supports a direct GTPase regulatory mechanism

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8 July 2022

Direct involvement of the small GTPase Rac in activation of the superoxide-producing NADPH oxidase Nox1.

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8 July 2022

Novel role of gp91(phox)-containing NAD(P)H oxidase in vascular endothelial growth factor-induced signaling and angiogenesis

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8 July 2022

Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidases

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8 July 2022

Role of the small GTPase Rac in p22phox-dependent NADPH oxidases

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8 July 2022

Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1

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8 July 2022

IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth

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8 July 2022

The IQGAP1 protein is a calmodulin-regulated barbed end capper of actin filaments: possible implications in its function in cell migration

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8 July 2022

The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases

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8 July 2022

Unraveling the molecular mechanism of interactions of the Rho GTPases Cdc42 and Rac1 with the scaffolding protein IQGAP2.

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8 July 2022

Rac GTPase interacts specifically with phosphatidylinositol 3-kinase

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8 July 2022

Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-kappaB

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8 July 2022

FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages

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8 July 2022

A novel partner for the GTP-bound forms of rho and rac

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8 July 2022

Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron

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8 July 2022

Molecular dissection of the interaction between the small G proteins Rac1 and RhoA and protein kinase C-related kinase 1 (PRK1)

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8 July 2022

The Rac1 polybasic region is required for interaction with its effector PRK1

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8 July 2022

Loop 6 of RhoA confers specificity for effector binding, stress fiber formation, and cellular transformation

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8 July 2022

Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms

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8 July 2022

PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia

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8 July 2022

ARF1 controls Rac1 signaling to regulate migration of MDA-MB-231 invasive breast cancer cells

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8 July 2022

Focal-adhesion targeting links caveolin-1 to a Rac1-degradation pathway

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8 July 2022

The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins

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8 July 2022

Serine-71 phosphorylation of Rac1 modulates downstream signaling

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8 July 2022

Regulation of p21-activated kinase-independent Rac1 signal transduction by nischarin

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8 July 2022

WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac

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8 July 2022

Optimization of WAVE2 complex-induced actin polymerization by membrane-bound IRSp53, PIP(3), and Rac.

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8 July 2022

Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain

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8 July 2022

The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton

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8 July 2022

Biochemical characterization of the Rho GTPase-regulated actin assembly by diaphanous-related formins, mDia1 and Daam1, in platelets

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8 July 2022

FMNL2 drives actin-based protrusion and migration downstream of Cdc42.

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8 July 2022

PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells

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8 July 2022

Molecular cloning and characterization of a novel human STE20-like kinase, hSLK.

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8 July 2022

A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformation

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8 July 2022

AR and ER interaction with a p21-activated kinase (PAK6)

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8 July 2022

Characterization of two alternately spliced forms of phospholipase D1. Activation of the purified enzymes by phosphatidylinositol 4,5-bisphosphate, ADP-ribosylation factor, and Rho family monomeric GTP-binding proteins and protein kinase C-alpha

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8 July 2022

Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome

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8 July 2022

Sema3A-induced growth-cone collapse is mediated by Rac1 amino acids 17-32.

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8 July 2022

Identifiers

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8 July 2022

(Q106518963)

RAC1 binds effectors at the plasma membrane

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