(Q1225690)

http://www.ebi.ac.uk/interpro/protein/P14735

Peptidase M16, N-terminal domain, protein family

1 reference

Peptidase M16, middle/third domain, protein family

1 reference

Peptidase M16, C-terminal domain, protein family

1 reference

Peptidase M16, zinc-binding site, protein family

1 reference

image of molecular model or crystal lattice model

Protein IDE PDB 2g47.png
966 × 535; 578 KB

0 references

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

virus receptor activity

1 reference

9 May 2019

1 reference

9 May 2019

In vitro degradation of insulin-like peptide 3 by insulin-degrading enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Molecular Basis of Catalytic Chamber-assisted Unfolding and Cleavage of Human Insulin by Human Insulin-degrading Enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

3 references

9 May 2019

In vitro degradation of insulin-like peptide 3 by insulin-degrading enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

4 references

14 February 2017

Insulin degrading enzyme is a cellular receptor mediating varicella-zoster virus infection and cell-to-cell spread

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P14735

9 May 2019

Insulin degrading enzyme is a cellular receptor mediating varicella-zoster virus infection and cell-to-cell spread

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

IPI

peptide hormone binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

beta-endorphin binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

1 reference

14 February 2017

Ubiquitin is a novel substrate for human insulin-degrading enzyme

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P14735

metalloendopeptidase activity

IPI

4 references

14 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P14735

14 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P14735

14 February 2017

Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P14735

14 February 2017

Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P14735

signaling receptor binding

1 reference

9 May 2019

A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

metallopeptidase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

metalloendopeptidase activity

5 references

9 May 2019

Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

ubiquitin-dependent protein binding

1 reference

9 May 2019

Ubiquitin is a novel substrate for human insulin-degrading enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

protein homodimerization activity

IPI

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Molecular Basis of Catalytic Chamber-assisted Unfolding and Cleavage of Human Insulin by Human Insulin-degrading Enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

Production of an antigenic peptide by insulin-degrading enzyme

endopeptidase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Insulin-degrading enzyme does not require peroxisomal localization for insulin degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Regional and cellular distribution patterns of insulin-degrading enzyme in the adult human brain and pituitary

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Transcriptional regulation of insulin-degrading enzyme modulates mitochondrial amyloid β (Aβ) peptide catabolism and functionality.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

3 references

14 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P14735

14 February 2017

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P14735

14 February 2017

Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P14735

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

1 reference

14 February 2017

Insulin-degrading enzyme does not require peroxisomal localization for insulin degradation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P14735

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

cytosolic proteasome complex

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

1 reference

14 February 2017

Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P14735

3 references

9 May 2019

Insulin-degrading enzyme does not require peroxisomal localization for insulin degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Regional and cellular distribution patterns of insulin-degrading enzyme in the adult human brain and pituitary

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

1 reference

14 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P14735

4 references

9 May 2019

Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

3 references

9 May 2019

Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Transcriptional regulation of insulin-degrading enzyme modulates mitochondrial amyloid β (Aβ) peptide catabolism and functionality.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

7 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Production of an antigenic peptide by insulin-degrading enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

external side of plasma membrane

1 reference

9 May 2019

Insulin degrading enzyme is localized predominantly at the cell surface of polarized and unpolarized human cerebrovascular endothelial cell cultures

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Insulin degrading enzyme is a cellular receptor mediating varicella-zoster virus infection and cell-to-cell spread

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Insulin degrading enzyme is localized predominantly at the cell surface of polarized and unpolarized human cerebrovascular endothelial cell cultures

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

basolateral plasma membrane

1 reference

9 May 2019

Insulin degrading enzyme is localized predominantly at the cell surface of polarized and unpolarized human cerebrovascular endothelial cell cultures

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

IMP

extracellular exosome

1 reference

9 May 2019

negative regulation of proteolysis

ISS

biological process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

insulin receptor signaling pathway

1 reference

9 May 2019

Human insulin-degrading enzyme shares structural and functional homologies with E. coli protease III

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

insulin metabolic process

NAS

1 reference

9 May 2019

Evidence that the gene encoding insulin degrading enzyme influences human lifespan

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

determination of adult lifespan

1 reference

9 May 2019

Evidence that the gene encoding insulin degrading enzyme influences human lifespan

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

protein heterooligomerization

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

hormone catabolic process

1 reference

14 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P14735

amyloid-beta metabolic process

3 references

14 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P14735

14 February 2017

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P14735

14 February 2017

Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P14735

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

In vitro degradation of insulin-like peptide 3 by insulin-degrading enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Ubiquitin is a novel substrate for human insulin-degrading enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

positive regulation of protein oligomerization

1 reference

9 May 2019

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

viral entry into host cell

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

1 reference

9 May 2019

Ubiquitin is a novel substrate for human insulin-degrading enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

protein homooligomerization

1 reference

9 May 2019

Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

protein homotetramerization

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

insulin catabolic process

3 references

9 May 2019

Insulin-degrading enzyme does not require peroxisomal localization for insulin degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Molecular Basis of Catalytic Chamber-assisted Unfolding and Cleavage of Human Insulin by Human Insulin-degrading Enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

protein targeting to peroxisome

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

protein catabolic process

TAS

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

positive regulation of protein catabolic process

ISS

1 reference

9 May 2019

Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

amyloid-beta metabolic process

TAS

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Characterization of insulin-degrading enzyme-mediated cleavage of Aβ in distinct aggregation states

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

proteolysis involved in cellular protein catabolic process

IBA

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

IBA

amyloid-beta clearance

4 references

9 May 2019

9 May 2019

Insulin degrading enzyme is localized predominantly at the cell surface of polarized and unpolarized human cerebrovascular endothelial cell cultures

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

amyloid-beta clearance by cellular catabolic process

3 references

regulation of aerobic respiration

1 reference

9 May 2019

Transcriptional regulation of insulin-degrading enzyme modulates mitochondrial amyloid β (Aβ) peptide catabolism and functionality.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

hormone catabolic process

IGI

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Molecular Basis of Catalytic Chamber-assisted Unfolding and Cleavage of Human Insulin by Human Insulin-degrading Enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

antigen processing and presentation of endogenous peptide antigen via MHC class I

IBA

1 reference

9 May 2019

Production of an antigenic peptide by insulin-degrading enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

peptide catabolic process

IMP

1 reference

9 May 2019

Production of an antigenic peptide by insulin-degrading enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14735

physically interacts with

1 reference

https://thebiogrid.org/news/227

retrieved

19 April 2020

stated in

BioGRID

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

Gene Atlas image

PBB GE IDE 203327 at fs.png
732 × 530; 11 KB

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Identifiers

1 reference

30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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13 November 2019

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28 October 2013

Microsoft Academic ID

0 references

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1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

4 August 2016

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4 August 2016

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