(Q30274560)

11 August 2017

Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes (English)

1 reference

11 August 2017

0 references

1 reference

LDL receptor related protein 1

1 reference

1 reference

Insulin degrading enzyme

1 reference

positive regulation of amyloid-beta clearance

1 reference

Low density lipoprotein receptor

1 reference

5

David M Holtzman

1 reference

11 August 2017

Jacob M Basak

1

1 reference

11 August 2017

Philip B Verghese

series ordinal

2

1 reference

11 August 2017

Hyejin Yoon

series ordinal

3

1 reference

11 August 2017

Jungsu Kim

series ordinal

4

1 reference

11 August 2017

language of work or name

English

0 references

publication date

1 March 2012

1 reference

Journal of Biological Chemistry

11 August 2017

13

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

11 August 2017

287

1 reference

11 August 2017

17

1 reference

11 August 2017

13959-13971

1 reference

describes a project that uses

11 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3340151/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Lack of LDL receptor enhances amyloid deposition and decreases glial response in an Alzheimer's disease mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

Human apoE isoforms differentially regulate brain amyloid-β peptide clearance

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

Alzheimer's disease: the challenge of the second century

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

Apolipoprotein E in Alzheimer's disease and other neurological disorders

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-beta uptake

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

Decreased clearance of CNS beta-amyloid in Alzheimer's disease

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

The role of microglia in amyloid clearance from the AD brain

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

Optimal promoter usage for lentiviral vector-mediated transduction of cultured central nervous system cells.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

Receptor-associated protein interacts with amyloid-beta peptide and promotes its cellular uptake

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

The role of apolipoprotein E in Alzheimer's disease

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

Binding and uptake of A beta1-42 by primary human astrocytes in vitro

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

ApoE promotes the proteolytic degradation of Abeta

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

The blood-brain barrier in health and chronic neurodegenerative disorders

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

A hundred years of Alzheimer's disease research

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

Clearance of Alzheimer's Abeta peptide: the many roads to perdition.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

Lipoprotein receptors in the nervous system

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

Clearing the brain's amyloid cobwebs

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

Amyloid beta-protein (Abeta)-containing astrocytes are located preferentially near N-terminal-truncated Abeta deposits in the human entorhinal cortex.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

Diffuse plaques in the molecular layer show intracellular A beta(8-17)-immunoreactive deposits in subpial astrocytes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

Astrocytes containing amyloid beta-protein (Abeta)-positive granules are associated with Abeta40-positive diffuse plaques in the aged human brain

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

Amyloid beta protein (A beta) removal by neuroglial cells in culture

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

Isoform-specific binding of apolipoprotein E to beta-amyloid

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

Early association of reactive astrocytes with senile plaques in Alzheimer's disease

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

A receptor-mediated pathway for cholesterol homeostasis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

Apolipoprotein E: cholesterol transport protein with expanding role in cell biology

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

Receptor-mediated endocytosis: concepts emerging from the LDL receptor system

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

Astrocytes and the plaques of Alzheimer's disease

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

Delivery of ligands from sorting endosomes to late endosomes occurs by maturation of sorting endosomes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340151

Astrocytes accumulate Aβ42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains

3 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.288746

Adult mouse astrocytes degrade amyloid-beta in vitro and in situ

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.288746

Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.288746

Unique lipoproteins secreted by primary astrocytes from wild type, apoE (-/-), and human apoE transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.288746

Matrix metalloproteinases expressed by astrocytes mediate extracellular amyloid-beta peptide catabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.288746

The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.288746

Lack of LDL receptor aggravates learning deficits and amyloid deposits in Alzheimer transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.288746

Internalization of beta-amyloid peptide by primary neurons in the absence of apolipoprotein E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.288746

apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.288746

ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.288746

Elevated plasma cholesterol does not affect brain Abeta in mice lacking the low-density lipoprotein receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.288746

21 January 2018

Identifiers

DOI

10.1074/JBC.M111.288746

1 reference

11 August 2017

1 reference

11 August 2017

PubMed publication ID

22383525

1 reference