(Q24317274)

amyloid-beta metabolic process

GOA release 2020-03-11

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GOA release 2020-03-11

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11

Wei-Jen Tang

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author name string

Hookang Im

1

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Marika Manolopoulou

2

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Enrico Malito

3

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Yuequan Shen

4

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Ji Zhao

5

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Marie Neant-Fery

6

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Ching-Yu Sun

7

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Stephen C Meredith

8

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Sangram S Sisodia

9

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Malcolm A Leissring

Journal of Biological Chemistry

10

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language of work or name

English

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publication date

31 August 2007

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published in

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volume

282

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issue

35

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page(s)

25453-63

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cites work

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Insulin-degrading enzyme: embarking on amyloid destruction.

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Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

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The insulysin (insulin degrading enzyme) enigma

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Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme

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Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

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Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein

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Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo

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Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death.

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Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

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Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis.

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Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families

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Quantitative trait loci near the insulin-degrading enzyme (IDE) gene contribute to variation in plasma insulin levels

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Polymorphisms in the insulin-degrading enzyme gene are associated with type 2 diabetes in men from the NHLBI Framingham Heart Study

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Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility

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Insulin degrading enzyme is localized predominantly at the cell surface of polarized and unpolarized human cerebrovascular endothelial cell cultures

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Cellular distribution of insulin-degrading enzyme gene expression. Comparison with insulin and insulin-like growth factor receptors

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Substrate activation of insulin-degrading enzyme (insulysin). A potential target for drug development.

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ATP effects on insulin-degrading enzyme are mediated primarily through its triphosphate moiety

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An insulin-degrading enzyme inhibitor decreases amylin degradation, increases amylin-induced cytotoxicity, and increases amyloid formation in insulinoma cell cultures

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Susceptibility of amyloid beta peptide degrading enzymes to oxidative damage: a potential Alzheimer's disease spiral

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In VitroInhibition of Insulin-Degrading Enzyme by Long-Chain Fatty Acids and Their Coenzyme A Thioesters

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The C-terminal domain of human insulin degrading enzyme is required for dimerization and substrate recognition.

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The closed structure of presequence protease PreP forms a unique 10,000 Angstroms3 chamber for proteolysis

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Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein

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Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

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The CCP4 suite: programs for protein crystallography

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Likelihood-enhanced fast translation functions

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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Refinement of macromolecular structures by the maximum-likelihood method

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Coot: model-building tools for molecular graphics

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Kinetics of amyloid beta-protein degradation determined by novel fluorescence- and fluorescence polarization-based assays

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Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates

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Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway

21 January 2018

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Crystal structures of mitochondrial processing peptidase reveal the mode for specific cleavage of import signal sequences

21 January 2018

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Degradation of the amyloid beta-protein by the novel mitochondrial peptidasome, PreP

21 January 2018

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Shape complementarity at protein/protein interfaces

21 January 2018

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Electrostatics of nanosystems: application to microtubules and the ribosome

21 January 2018

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ConSurf 2005: the projection of evolutionary conservation scores of residues on protein structures

21 January 2018

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Beta-amyloid precursor protein cleavage by a membrane-bound protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701590200

Mutation of active site residues of insulin-degrading enzyme alters allosteric interactions

21 January 2018

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MEROPS: the peptidase database.

21 January 2018

1 reference

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Characterization of the binding of the fluorescent ATP analog TNP-ATP to insulysin

21 January 2018

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The CCP4 molecular-graphics project

21 January 2018

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Abeta40-Lactam(D23/K28) models a conformation highly favorable for nucleation of amyloid

21 January 2018

1 reference

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Enzyme target to latch on to

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701590200

Non-covalent interaction of ubiquitin with insulin-degrading enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701590200

inferred from DOI database lookup

7 January 2021

based on heuristic

Evidence for genetic linkage of Alzheimer's disease to chromosome 10q

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701590200