(Q14862284)

http://www.ebi.ac.uk/interpro/protein/O55042

membrane proteins

1 reference

based on heuristic

inferred from GOA cell component → membrane

1 reference

25 May 2022

1 reference

25 May 2022

arachidonic acid binding

1 reference

9 May 2019

Acyl-CoA synthetase activity links wild-type but not mutant alpha-synuclein to brain arachidonate metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

9 May 2019

Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

identical protein binding

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

9 May 2019

Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O55042&geneProductId=UniProtKB:O55042

1 reference

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=O55042&geneProductId=UniProtKB:O55042

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

9 May 2019

Expression of alpha-synuclein, a presynaptic protein implicated in Parkinson's disease, in erythropoietic lineage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

9 May 2019

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

9 May 2019

Alpha-synuclein and polyunsaturated fatty acids promote clathrin-mediated endocytosis and synaptic vesicle recycling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

1 reference

9 May 2019

Alpha-synuclein induces hyperphosphorylation of Tau in the MPTP model of parkinsonism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

9 May 2019

Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

9 May 2019

α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

9 May 2019

Expression of alpha-synuclein, a presynaptic protein implicated in Parkinson's disease, in erythropoietic lineage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

9 May 2019

Relationships between the sequence of alpha-synuclein and its membrane affinity, fibrillization propensity, and yeast toxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

9 May 2019

Ankyrin repeat and BTB/POZ domain containing protein-2 inhibits the aggregation of alpha-synuclein: implications for Parkinson's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

9 May 2019

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

synaptic vesicle membrane

1 reference

9 May 2019

Synucleins Have Multiple Effects on Presynaptic Architecture

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

regulation of glutamate secretion

biological process

1 reference

9 May 2019

Role of alpha-synuclein in synaptic glutamate release

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

positive regulation of synaptic transmission

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

regulation of dopamine secretion

3 references

9 May 2019

Synaptic vesicle trafficking and Parkinson's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

9 May 2019

Increased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synuclein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

regulation of long-term neuronal synaptic plasticity

1 reference

9 May 2019

alpha-Synuclein produces a long-lasting increase in neurotransmitter release

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

regulation of locomotion

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

adult locomotory behavior

1 reference

9 May 2019

Increased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synuclein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

positive regulation of neurotransmitter secretion

1 reference

9 May 2019

alpha-Synuclein produces a long-lasting increase in neurotransmitter release

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

cellular response to fibroblast growth factor stimulus

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

positive regulation of peptidyl-serine phosphorylation

1 reference

9 May 2019

Parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and alpha-synuclein mutations promote Tau protein phosphorylation at Ser262 and destabilize microtubule cytoskeleton in vitro

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

regulation of acyl-CoA biosynthetic process

synaptic vesicle endocytosis

1 reference

21 June 2018

Alpha-synuclein and polyunsaturated fatty acids promote clathrin-mediated endocytosis and synaptic vesicle recycling

http://www.ebi.ac.uk/QuickGO/annotations?protein=O55042&geneProductId=UniProtKB:O55042

excitatory postsynaptic potential

1 reference

9 May 2019

Alpha-synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMKII

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

regulation of neuronal synaptic plasticity

1 reference

9 May 2019

Alpha-synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMKII

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

mitochondrial membrane organization

1 reference

9 May 2019

Mitochondrial lipid abnormality and electron transport chain impairment in mice lacking alpha-synuclein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

chemical synaptic transmission

1 reference

9 May 2019

αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

mitochondrial ATP synthesis coupled electron transport

1 reference

9 May 2019

Mitochondrial lipid abnormality and electron transport chain impairment in mice lacking alpha-synuclein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

dopamine biosynthetic process

1 reference

9 May 2019

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

1 reference

9 May 2019

αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

regulation of reactive oxygen species metabolic process

1 reference

9 May 2019

Genetic deletion of the GATA1-regulated protein α-synuclein reduces oxidative stress and nitric oxide synthase levels in mature erythrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

regulation of neurotransmitter secretion

4 references

9 May 2019

Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

9 May 2019

alpha-Synuclein produces a long-lasting increase in neurotransmitter release

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

9 May 2019

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

9 May 2019

Increased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synuclein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

microglial cell activation

1 reference

9 May 2019

Alpha-synuclein expression modulates microglial activation phenotype

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

neutral lipid metabolic process

1 reference

9 May 2019

Brain neutral lipids mass is increased in alpha-synuclein gene-ablated mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

Altered Fatty Acid Composition of Dopaminergic Neurons Expressing α-Synuclein and Human Brains with α-Synucleinopathies

membrane organization

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

dopamine metabolic process

1 reference

9 May 2019

Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

synaptic vesicle transport

1 reference

9 May 2019

Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

cellular response to oxidative stress

1 reference

9 May 2019

Mice lacking alpha-synuclein are resistant to mitochondrial toxins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

phospholipid metabolic process

3 references

9 May 2019

Mitochondrial lipid abnormality and electron transport chain impairment in mice lacking alpha-synuclein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

9 May 2019

Alpha-synuclein gene deletion decreases brain palmitate uptake and alters the palmitate metabolism in the absence of alpha-synuclein palmitate binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

9 May 2019

Acyl-CoA synthetase activity links wild-type but not mutant alpha-synuclein to brain arachidonate metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

regulation of macrophage activation

1 reference

9 May 2019

Alpha-synuclein expression modulates microglial activation phenotype

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

Role of alpha-synuclein in synaptic glutamate release

long-term potentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

response to desipramine

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

negative regulation of neuron apoptotic process

regulation of transmembrane transporter activity

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O55042&geneProductId=UniProtKB:O55042

regulation of norepinephrine uptake

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O55042&geneProductId=UniProtKB:O55042

synaptic vesicle endocytosis

4 references

9 May 2019

Alpha-synuclein and polyunsaturated fatty acids promote clathrin-mediated endocytosis and synaptic vesicle recycling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

9 May 2019

Synucleins regulate the kinetics of synaptic vesicle endocytosis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

9 May 2019

Synucleins regulate the kinetics of synaptic vesicle endocytosis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

9 May 2019

Synucleins regulate the kinetics of synaptic vesicle endocytosis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

synaptic vesicle exocytosis

EXP

1 reference

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=O55042&geneProductId=UniProtKB:O55042

positive regulation of exocytosis

1 reference

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=O55042&geneProductId=UniProtKB:O55042

protein complex oligomerization

1 reference

9 May 2019

α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

protein tetramerization

1 reference

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=O55042&geneProductId=UniProtKB:O55042

SNARE complex assembly

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

9 May 2019

α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042

synaptic vesicle priming

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042