(Q24311461)

English

Parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and alpha-synuclein mutations promote Tau protein phosphorylation at Ser262 and destabilize microtubule cytoskeleton in vitro

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scholarly article

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Parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and alpha-synuclein mutations promote Tau protein phosphorylation at Ser262 and destabilize microtubule cytoskeleton in vitro (English)

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Synuclein alpha

1 reference

GOA release 2020-03-11

positive regulation of protein serine/threonine kinase activity

1 reference

GOA release 2020-03-11

Synuclein, alpha

1 reference

GOA release 2020-03-11

phosphorylation

1 reference

based on heuristic

inferred from title

Parkinson's disease

2 references

based on heuristic

inferred from title

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Hamid Y Qureshi

1

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Hemant K Paudel

2

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language of work or name

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publication date

18 February 2011

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Journal of Biological Chemistry

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286

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7

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5055-68

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Genome-wide association study reveals genetic risk underlying Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

19 March 2017

Tubulin seeds alpha-synuclein fibril formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

19 March 2017

The regulatory Ser262 of microtubule-associated protein tau is phosphorylated by phosphorylase kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

19 March 2017

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

19 March 2017

Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

19 March 2017

alpha-Synuclein shares physical and functional homology with 14-3-3 proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

19 March 2017

Phosphorylation of tau at Ser214 mediates its interaction with 14-3-3 protein: implications for the mechanism of tau aggregation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

19 March 2017

Alpha-synuclein induces hyperphosphorylation of Tau in the MPTP model of parkinsonism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

19 March 2017

Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

19 March 2017

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

7 April 2017

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

7 April 2017

Neurodegenerative tauopathies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

7 April 2017

A Drosophila model of Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

7 April 2017

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

7 April 2017

Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

27 September 2017

Molecular interaction of α-synuclein with tubulin influences on the polymerization of microtubule in vitro and structure of microtubule in cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

27 September 2017

Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

27 September 2017

Alpha-Synuclein contributes to GSK-3beta-catalyzed Tau phosphorylation in Parkinson's disease models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

27 September 2017

Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

27 September 2017

Molecular mechanisms of alpha-synuclein neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

27 September 2017

Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

27 September 2017

Controlling the mass action of alpha-synuclein in Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

27 September 2017

Untangling the tau gene association with neurodegenerative disorders.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

27 September 2017

Expanding insights of mitochondrial dysfunction in Parkinson's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

27 September 2017

The MPTP model of Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

27 September 2017

alpha-Synuclein: a potent inducer of tau pathology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

27 September 2017

Colocalization of Tau and Alpha-Synuclein Epitopes in Lewy Bodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

27 September 2017

Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

27 September 2017

Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

27 September 2017

Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

27 September 2017

Cellular co-localization of phosphorylated tau- and NACP/alpha-synuclein-epitopes in lewy bodies in sporadic Parkinson's disease and in dementia with Lewy bodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

27 September 2017

alpha-synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

27 September 2017

Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

27 September 2017

Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

27 September 2017

Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

30 May 2018

Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

30 May 2018

alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

30 May 2018

Proline-directed and non-proline-directed phosphorylation of PHF-tau.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

30 May 2018

Parkinson disease, dementia, and Alzheimer disease: clinicopathological correlations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

30 May 2018

Phosphorylation of recombinant tau by cAMP-dependent protein kinase. Identification of phosphorylation sites and effect on microtubule assembly.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037617

30 May 2018

More than just two peas in a pod: common amyloidogenic properties of tau and alpha-synuclein in neurodegenerative diseases

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https://api.crossref.org/works/10.1074%2FJBC.M110.178905

21 January 2018

Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.178905

21 January 2018

Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.178905

21 January 2018

The parkinsonism producing neurotoxin MPP+ affects microtubule dynamics by acting as a destabilising factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.178905

21 January 2018

Mice lacking alpha-synuclein have an attenuated loss of striatal dopamine following prolonged chronic MPTP administration

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.178905

21 January 2018

Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.178905

21 January 2018

PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.178905

21 January 2018

Association of an extended haplotype in the tau gene with progressive supranuclear palsy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.178905

21 January 2018

Genetic evidence for the involvement of tau in progressive supranuclear palsy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.178905

21 January 2018

The H1c haplotype at the MAPT locus is associated with Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.178905

21 January 2018

Fibrillization of alpha-synuclein and tau in familial Parkinson's disease caused by the A53T alpha-synuclein mutation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.178905

21 January 2018

Tau and 14-3-3 in glial cytoplasmic inclusions of multiple system atrophy

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https://api.crossref.org/works/10.1074%2FJBC.M110.178905

21 January 2018

Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein

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https://api.crossref.org/works/10.1074%2FJBC.M110.178905

21 January 2018

Tau phosphorylation increases in symptomatic mice overexpressing A30P alpha-synuclein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.178905

21 January 2018

The Parkinson disease-associated A30P mutation stabilizes alpha-synuclein against proteasomal degradation triggered by heme oxygenase-1 over-expression in human neuroblastoma cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.178905

21 January 2018

Familial FTDP-17 missense mutations inhibit microtubule assembly-promoting activity of tau by increasing phosphorylation at Ser202 in vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.178905

21 January 2018

Role of alpha-synuclein carboxy-terminus on fibril formation in vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.178905

21 January 2018

Glycogen synthase kinase-3beta is complexed with tau protein in brain microtubules

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.178905

21 January 2018

Detection of phosphorylated Ser262 in fetal tau, adult tau, and paired helical filament tau.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.178905

21 January 2018

The mouse MPTP model: gene expression changes in dopaminergic neurons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.178905

21 January 2018

Selective vulnerability of dopaminergic neurons to microtubule depolymerization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.178905

21 January 2018

Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.178905

21 January 2018

Phosphorylation Sites on Tau Identified by Nanoelectrospray Mass Spectrometry

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.178905

21 January 2018

Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.178905

21 January 2018

Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/21127069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cAMP analog antagonists of cAMP action

1 reference

https://pubmed.ncbi.nlm.nih.gov/21127069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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