(Q47987669)

7 February 2018

title

PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila (English)

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7 February 2018

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Isao Nishimura

1

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7 February 2018

Yufeng Yang

series ordinal

2

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7 February 2018

Bingwei Lu

series ordinal

3

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7 February 2018

language of work or name

English

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publication date

1 March 2004

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7 February 2018

published in

Cell

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7 February 2018

volume

116

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7 February 2018

issue

5

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7 February 2018

page(s)

671-682

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7 February 2018

Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease.

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https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity

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https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Mammalian homologues of C. elegans PAR-1 are asymmetrically localized in epithelial cells and may influence their polarity

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https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Neuropathological stageing of Alzheimer-related changes

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7 January 2021

The cyclin-dependent kinase Cdk5 controls multiple aspects of axon patterning in vivo

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https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Drosophila par-1 is required for oocyte differentiation and microtubule organization.

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https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

A very incomplete comprehensive theory of Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption

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https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Neurodegenerative disorders with extensive tau pathology: a comparative study and review

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https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Frontotemporal dementia and parkinsonism linked to chromosome 17: a consensus conference. Conference Participants

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7 January 2021

Neurofibrillary pathology of Alzheimer's disease and other tauopathies.

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https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Molecular dissection of the paired helical filament

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Identification and characterization of the Drosophila tau homolog.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Microtubule/MAP-affinity regulating kinase (MARK) is activated by phenylarsine oxide in situ and phosphorylates tau within its microtubule-binding domain

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis

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7 January 2021

Neurodegenerative tauopathies

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https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Tau protein is phosphorylated by cyclic AMP-dependent protein kinase and calcium/calmodulin-dependent protein kinase II within its microtubule-binding domains at Ser-262 and Ser-356.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Alzheimer's disease. The tangled tale of tau.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Tau in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Characterization of tau phosphorylation in glycogen synthase kinase-3beta and cyclin dependent kinase-5 activator (p23) transfected cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Glycogen synthase kinase 3 phosphorylates recombinant human tau protein at serine-262 in the presence of heparin (or tubulin)

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Cdk5 is a key factor in tau aggregation and tangle formation in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Anterior-posterior polarity in C. elegans and Drosophila--PARallels and differences

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Tau is a candidate gene for chromosome 17 frontotemporal dementia

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Par-1 regulates stability of the posterior determinant Oskar by phosphorylation.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Alzheimer's disease is a synaptic failure

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Detection of phosphorylated Ser262 in fetal tau, adult tau, and paired helical filament tau.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

The Drosophila homolog of C. elegans PAR-1 organizes the oocyte cytoskeleton and directs oskar mRNA localization to the posterior pole

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

A Drosophila melanogaster homologue of Caenorhabditis elegans par-1 acts at an early step in embryonic-axis formation.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900170-9

7 January 2021

10.1016/S0092-8674(04)00170-9

Identifiers

DOI

1 reference

7 February 2018

1 reference

7 February 2018