(Q44662134)

5 December 2017

Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila (English)

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5 December 2017

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7

Daniel H Geschwind

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5 December 2017

George R Jackson

1

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5 December 2017

Martina Wiedau-Pazos

2

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5 December 2017

Tzu-Kang Sang

3

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5 December 2017

Naveed Wagle

4

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5 December 2017

Carlos A Brown

5

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5 December 2017

Sasan Massachi

6

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5 December 2017

language of work or name

English

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publication date

1 May 2002

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5 December 2017

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5 December 2017

34

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5 December 2017

509-519

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5 December 2017

4

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Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development.

5 December 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Does dysregulation of the Notch and wingless/Wnt pathways underlie the pathogenesis of Alzheimer's disease?

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Morphological criteria for the recognition of Alzheimer's disease and the distribution pattern of cortical changes related to this disorder.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Neurofibrillary tangles and tau phosphorylation.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Wnt signaling: a common theme in animal development

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Straight and paired helical filaments in Alzheimer disease have a common structural unit

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

The microtubule binding repeats of tau protein assemble into filaments like those found in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Signal transduction by the Wnt family of ligands

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

In vivo activation and nuclear translocation of phosphorylated glycogen synthase kinase-3beta in neuronal apoptosis: links to tau phosphorylation.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

A Drosophila model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Modeling human neurodegenerative diseases in Drosophila: on a wing and a prayer.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

EGF receptor/Rolled MAP kinase signalling protects cells against activated Armadillo in the Drosophila eye.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Pro-apoptotic effects of tau mutations in chromosome 17 frontotemporal dementia and parkinsonism

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Dementia and neurodevelopmental predisposition: cognitive dysfunction in presymptomatic subjects precedes dementia by decades in frontotemporal dementia

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Phosphorylation of tau protein by recombinant GSK-3beta: pronounced phosphorylation at select Ser/Thr-Pro motifs but no phosphorylation at Ser262 in the repeat domain

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Tau mutations cause frontotemporal dementias.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Tau gene mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). Their relevance for understanding the neurogenerative process

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Apoptosis in neural crest cells by functional loss of APC tumor suppressor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Identification and characterization of the Drosophila tau homolog.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Unique Alzheimer's disease paired helical filament specific epitopes involve double phosphorylation at specific sites.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Frequency oftau mutations in three series of non-Alzheimer's degenerative dementia

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Glycogen synthase kinase 3β is identical to tau protein kinase I generating several epitopes of paired helical filaments

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Presenilin 1 independently regulates beta-catenin stability and transcriptional activity

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Glycogen synthase kinase-3beta regulates presenilin 1 C-terminal fragment levels.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Epitopes that span the tau molecule are shared with paired helical filaments.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Neurodegenerative tauopathies

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Ectopic and increased expression of Fasciclin II alters motoneuron growth cone guidance

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Requirement for DCP-1 caspase during Drosophila oogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

The genetic and pathological classification of familial frontotemporal dementia.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

PHF-tau from Alzheimer's brain comprises four species on SDS-PAGE which can be mimicked by in vitro phosphorylation of human brain tau by glycogen synthase kinase-3 beta.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Modelling neurodegenerative diseases in Drosophila: a fruitful approach?

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Chromatin condensation during apoptosis is accompanied by degradation of lamin A+B, without enhanced activation of cdc2 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Drosophila p53 is a structural and functional homolog of the tumor suppressor p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Presenilin 1 regulates beta-catenin-mediated transcription in a glycogen synthase kinase-3-independent fashion

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Multiple functions of segment polarity genes in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Molecular analysis of the armadillo locus: uniformly distributed transcripts and a protein with novel internal repeats are associated with a Drosophila segment polarity gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

The locus elav of Drosophila melanogaster is expressed in neurons at all developmental stages.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Genetic Transformation of Drosophila with Transposable Element Vectors

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Uncoupling cadherin-based adhesion from wingless signalling in Drosophila.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Interconversion of Drosophila nuclear lamin isoforms during oogenesis, early embryogenesis, and upon entry of cultured cells into mitosis

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Biosynthesis and interconversion of Drosophila nuclear lamin isoforms during normal growth and in response to heat shock

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Glycogen synthase kinase-3 beta phosphorylates tau protein at multiple sites in intact cells

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Transposition of cloned P elements into Drosophila germ line chromosomes.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Overexpression of zeste white 3 blocks wingless signaling in the Drosophila embryonic midgut.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

DNA damage and activated caspase-3 expression in neurons and astrocytes: evidence for apoptosis in frontotemporal dementia

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Glycogen synthase kinase-3beta is complexed with tau protein in brain microtubules

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Functional analysis of CNK in RAS signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Autonomous requirements for the segment polarity gene armadillo during Drosophila embryogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Beta-catenin: a key mediator of Wnt signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Tau and tau reporters disrupt central projections of sensory neurons in Drosophila.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900706-7

7 January 2021

10.1016/S0896-6273(02)00706-7

Identifiers

DOI

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5 December 2017

1 reference