(Q40773897)

23 September 2017

Presenilin 1 independently regulates beta-catenin stability and transcriptional activity (English)

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23 September 2017

Killick R

1

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23 September 2017

Pollard CC

2

1 reference

23 September 2017

Asuni AA

3

1 reference

23 September 2017

Mudher AK

4

1 reference

23 September 2017

Richardson JC

5

1 reference

23 September 2017

Rupniak HT

6

1 reference

23 September 2017

Sheppard PW

7

1 reference

23 September 2017

Varndell IM

8

1 reference

23 September 2017

Brion JP

9

1 reference

23 September 2017

Levey AI

10

1 reference

23 September 2017

Levy OA

11

1 reference

23 September 2017

Vestling M

12

1 reference

23 September 2017

Cowburn R

13

1 reference

23 September 2017

Lovestone S

14

1 reference

23 September 2017

Anderton BH

15

1 reference

23 September 2017

language of work or name

English

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publication date

17 October 2001

1 reference

Journal of Biological Chemistry

23 September 2017

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23 September 2017

276

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23 September 2017

48554-48561

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23 September 2017

51

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The biological and pathological function of presenilin proteins--simple cell systems and a worm in Alzheimer's disease research

23 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

Presenilin is required for activity and nuclear access of Notch in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

Presenilin 1 interaction in the brain with a novel member of the Armadillo family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

Direct association of presenilin-1 with beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

Presenilin affects arm/beta-catenin localization and function in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

Inhibitory effect of a presenilin 1 mutation on the Wnt signalling pathway by enhancement of beta-catenin phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

Bridging of beta-catenin and glycogen synthase kinase-3beta by axin and inhibition of beta-catenin-mediated transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

Dishevelled-1 regulates microtubule stability: a new function mediated by glycogen synthase kinase-3beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

Interaction of axin and Dvl-2 proteins regulates Dvl-2-stimulated TCF-dependent transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

E-Cadherin Suppresses Cellular Transformation by Inhibiting β-Catenin Signaling in an Adhesion-Independent Manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

Regulation of E-cadherin/Catenin association by tyrosine phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

Regulation of beta-catenin structure and activity by tyrosine phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

Regulation of N-cadherin-mediated adhesion by the p35-Cdk5 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

p35/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin/presenilin-1 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108332200

21 January 2018

Identifiers

DOI

10.1074/JBC.M108332200

0 references

1 reference