(Q14864755)

English

LPL

protein-coding gene in the species Homo sapiens

HDLCQ11
LIPD
lipoprotein lipase

In more languages

Statements

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000175445

protein-coding gene

1 reference

Ensembl Release 87

Ensembl gene ID

ENSG00000175445

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000175445

lipoprotein lipase

1 reference

6 July 2017

UniProt protein ID

Lipoprotein lipase

1 reference

UniProt protein ID

20 March 2016

language of work or name

genetic association

metabolic disease

determination method

genome-wide association study

1 reference

https://gemma.msl.ubc.ca/phenotypes.html?phenotypeUrlId=DOID_0014667&ncbiId=4023

http://www.genome.gov/gwastudies/index.cfm?gene=LPL

Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits

25 May 2020

lipid metabolism disorder

determination method

genome-wide association study

1 reference

https://gemma.msl.ubc.ca/phenotypes.html?phenotypeUrlId=DOID_3146&ncbiId=4023

http://www.genome.gov/gwastudies/index.cfm?gene=LPL

Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis

25 May 2020

familial lipoprotein lipase deficiency

2 references

UniProt protein ID

13 August 2019

Open Targets Platform

24 August 2023

https://platform.opentargets.org/evidence/ENSG00000175445/MONDO_0009387

based on heuristic

inferred from an Open Targets association score over 0.7

hyperlipoproteinemia, type 1D

1 reference

Open Targets Platform

24 August 2023

https://platform.opentargets.org/evidence/ENSG00000175445/Orphanet_411

based on heuristic

inferred from an Open Targets association score over 0.7

mixed hyperlipidemia

1 reference

Open Targets Platform

24 August 2023

https://platform.opentargets.org/evidence/ENSG00000175445/Orphanet_79211

based on heuristic

inferred from an Open Targets association score over 0.7

human chromosome 8

genomic assembly

genome assembly GRCh38

Genome assembly GRCh37

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000175445

strand orientation

genomic assembly

genome assembly GRCh38

Genome assembly GRCh37

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000175445

19901717

human chromosome 8

genomic assembly

genome assembly GRCh38

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000175445

19759228

human chromosome 8

genomic assembly

Genome assembly GRCh37

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000175445

19824769

human chromosome 8

genomic assembly

Genome assembly GRCh37

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000175445

19967259

human chromosome 8

genomic assembly

genome assembly GRCh38

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000175445

cytogenetic location

8p21.3

1 reference

15 May 2022

molecular function

lipoprotein lipase activity

determination method

8 references

9 May 2017

Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

9 May 2017

MicroRNA-590 attenuates lipid accumulation and pro-inflammatory cytokine secretion by targeting lipoprotein lipase gene in human THP-1 macrophages

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

9 May 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

9 May 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

9 May 2017

Lipoprotein lipaseBethesda: a single amino acid substitution (Ala-176----Thr) leads to abnormal heparin binding and loss of enzymic activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

9 May 2017

Rapid and simple isolation procedure for lipoprotein lipase from human milk

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

9 May 2017

Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

phospholipase activity

determination method

1 reference

9 May 2017

Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

triglyceride lipase activity

determination method

4 references

9 May 2017

Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

9 May 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

9 May 2017

VLDL-induced triglyceride accumulation in human macrophages is mediated by modulation of LPL lipolytic activity in the absence of change in LPL mass

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

9 May 2017

Effect of serum and C-apoproteins from very low density lipoproteins on human postheparin plasma hepatic lipase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

signaling receptor binding

determination method

1 reference

9 May 2017

Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

protein binding

determination method

1 reference

9 May 2017

Chylomicronemia with low postheparin lipoprotein lipase levels in the setting of GPIHBP1 defects

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

heparin binding

determination method

4 references

9 May 2017

Missense mutation (Gly----Glu188) of human lipoprotein lipase imparting functional deficiency

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

9 May 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

9 May 2017

Lipoprotein lipaseBethesda: a single amino acid substitution (Ala-176----Thr) leads to abnormal heparin binding and loss of enzymic activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

9 May 2017

VLDL-induced triglyceride accumulation in human macrophages is mediated by modulation of LPL lipolytic activity in the absence of change in LPL mass

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

hydrolase activity

determination method

1 reference

9 May 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

triglyceride binding

determination method

1 reference

9 May 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

apolipoprotein binding

determination method

1 reference

9 May 2017

Mechanism of triglyceride lowering in mice expressing human apolipoprotein A5

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

carboxylic ester hydrolase activity

determination method

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

extracellular region

determination method

extracellular space

determination method

5 references

9 May 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

9 May 2017

Human colostrum: identification of minor proteins in the aqueous phase by proteomics

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

9 May 2017

Identification and characterization of two novel mutations in the LPL gene causing type I hyperlipoproteinemia

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

9 May 2017

Rapid and simple isolation procedure for lipoprotein lipase from human milk

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

9 May 2017

VLDL-induced triglyceride accumulation in human macrophages is mediated by modulation of LPL lipolytic activity in the absence of change in LPL mass

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

plasma membrane

determination method

1 reference

9 May 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

determination method

1 reference

9 May 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

determination method

1 reference

9 May 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

extracellular matrix

determination method

1 reference

9 May 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

anchored component of membrane

determination method

1 reference

9 May 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

very-low-density lipoprotein particle

determination method

1 reference

9 May 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

determination method

1 reference

9 May 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

extracellular exosome

determination method

1 reference

9 May 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

biological process

retinoid metabolic process

determination method

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

lipid metabolism

determination method

2 references

fatty acid biosynthetic process

determination method

3 references

9 May 2017

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

9 May 2017

Effect of serum and C-apoproteins from very low density lipoproteins on human postheparin plasma hepatic lipase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

9 May 2017

Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

triglyceride metabolic process

determination method

1 reference

9 May 2017

Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

phospholipid metabolic process

determination method

1 reference

9 May 2017

Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

response to cold

determination method

1 reference

9 May 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

response to glucose

determination method

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

positive regulation of cholesterol storage

determination method

1 reference

9 May 2017

VLDL-induced triglyceride accumulation in human macrophages is mediated by modulation of LPL lipolytic activity in the absence of change in LPL mass

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

positive regulation of sequestering of triglyceride

determination method

1 reference

9 May 2017

VLDL-induced triglyceride accumulation in human macrophages is mediated by modulation of LPL lipolytic activity in the absence of change in LPL mass

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

triglyceride catabolic process

determination method

6 references

9 May 2017

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

9 May 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

9 May 2017

Lipoprotein lipaseBethesda: a single amino acid substitution (Ala-176----Thr) leads to abnormal heparin binding and loss of enzymic activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

9 May 2017

Rapid and simple isolation procedure for lipoprotein lipase from human milk

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

9 May 2017

Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

9 May 2017

Effect of serum and C-apoproteins from very low density lipoproteins on human postheparin plasma hepatic lipase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

cholesterol homeostasis

determination method

1 reference

9 May 2017

MicroRNA-590 attenuates lipid accumulation and pro-inflammatory cytokine secretion by targeting lipoprotein lipase gene in human THP-1 macrophages

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

positive regulation of inflammatory response

determination method

1 reference

9 May 2017

MicroRNA-590 attenuates lipid accumulation and pro-inflammatory cytokine secretion by targeting lipoprotein lipase gene in human THP-1 macrophages

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

regulation of lipoprotein lipase activity

determination method

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

low-density lipoprotein particle mediated signaling

determination method

1 reference

9 May 2017

MicroRNA-590 attenuates lipid accumulation and pro-inflammatory cytokine secretion by targeting lipoprotein lipase gene in human THP-1 macrophages

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

triglyceride homeostasis

determination method

1 reference

9 May 2017

Reduction of plasma triglycerides in apolipoprotein C-II transgenic mice overexpressing lipoprotein lipase in muscle

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

determination method

200

1 reference

15 May 2022

Gene Atlas image

PBB GE LPL 203549 s at fs.png
732 × 530; 10 KB

0 references

PBB GE LPL 203548 s at fs.png
732 × 530; 10 KB

0 references

1 reference

HomoloGene build68

200

1 reference

HomoloGene build68

200

1 reference

HomoloGene build68

200

1 reference

HomoloGene build68

200

1

1 reference

28 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000175445

trigeminal ganglion

2

1 reference

28 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000175445

right ventricle

3

1 reference

28 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000175445

4

1 reference

28 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000175445

5

1 reference

28 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000175445

6

1 reference

28 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000175445

subcutaneous adipose tissue

7

1 reference

28 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000175445

8

1 reference

28 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000175445

thoracic diaphragm

9

1 reference

28 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000175445

10

1 reference

28 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000175445

http://identifiers.org/ncbigene/4023

1 reference

Identifiers.org

http://www.ebi.ac.uk/miriam/main/collections/MIR:00000069

Identifiers

1 reference

15 May 2022

1 reference

15 May 2022

Encyclopædia Britannica Online ID

topic/lipoprotein-lipase

subject named as

lipoprotein lipase

0 references

Ensembl gene ID

ENSG00000175445

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000175445

Ensembl transcript ID

ENST00000524029

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000175445

ENST00000519773

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000175445

ENST00000520959

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000175445

ENST00000521994

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000175445

ENST00000522701

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000175445

ENST00000523696

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000175445

ENST00000650478

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000175445

ENST00000650287

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000175445

HGNC gene symbol

1 reference

15 May 2022

1 reference

15 May 2022

1 reference

Online Mendelian Inheritance in Man

19 August 2019

1 reference

based on heuristic

inferred by common HGNC mappings on source and on Wikidata

15 June 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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