(Q14883757)

Winged helix DNA-binding domain superfamily

1 reference

Ribonuclease H superfamily

1 reference

Ribonuclease H-like superfamily

1 reference

P-loop containing nucleoside triphosphate hydrolase

1 reference

Winged helix-like DNA-binding domain superfamily

1 reference

HRDC-like superfamily

1 reference

Helicase superfamily 1/2, ATP-binding domain, protein family

1 reference

ATP-dependent DNA helicase RecQ, zinc-binding domain, protein family

1 reference

Helicase Helix-turn-helix domain, protein family

1 reference

Helicase, C-terminal domain, protein family

1 reference

DEAD/DEAH box helicase

1 reference

3'-5' exonuclease domain, protein family

1 reference

HRDC domain, protein family

1 reference

RQC domain, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

1 reference

25 May 2022

1 reference

25 May 2022

manganese ion binding

1 reference

9 May 2019

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

1 reference

9 May 2019

A novel protein interacts with the Werner's syndrome gene product physically and functionally

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

3'-5' exonuclease activity

IPI

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

9 May 2019

Characterization of the human and mouse WRN 3'-->5' exonuclease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

magnesium ion binding

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

four-way junction helicase activity

magnesium ion binding

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

four-way junction DNA binding

3 references

3 references

3 references

3 references

3'-5' exonuclease activity

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

14 February 2019

Characterization of the human and mouse WRN 3'-->5' exonuclease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

manganese ion binding

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

MutLalpha complex binding

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09053&geneProductId=UniProtKB:O09053

protein homodimerization activity

3 references

protein-containing complex binding

3 references

forked DNA-dependent helicase activity

3 references

telomeric D-loop binding

3 references

3'-flap-structured DNA binding

3 references

8-hydroxy-2'-deoxyguanosine DNA binding

3 references

intracellular anatomical structure

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09053&geneProductId=UniProtKB:O09053

4 references

24 April 2018

Diverged nuclear localization of Werner helicase in human and mouse cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09053&geneProductId=UniProtKB:O09053

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09053&geneProductId=UniProtKB:O09053

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09053&geneProductId=UniProtKB:O09053

24 April 2018

Diverged nuclear localization of Werner helicase in human and mouse cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09053&geneProductId=UniProtKB:O09053

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

1 reference

9 May 2019

BLM helicase facilitates telomere replication during leading strand synthesis of telomeres

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

9 May 2019

Diverged nuclear localization of Werner helicase in human and mouse cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

9 May 2019

Diverged nuclear localization of Werner helicase in human and mouse cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

14 February 2019

BLM helicase facilitates telomere replication during leading strand synthesis of telomeres

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

9 May 2019

A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

5 references

9 May 2019

Diverged nuclear localization of Werner helicase in human and mouse cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

9 May 2019

Diverged nuclear localization of Werner helicase in human and mouse cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

DNA replication factor A complex

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

3 references

site of double-strand break

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09053&geneProductId=UniProtKB:O09053

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09053&geneProductId=UniProtKB:O09053

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

DNA metabolic process

5 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

9 May 2019

Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

9 May 2019

Increased frequency of DNA deletions in pink-eyed unstable mice carrying a mutation in the Werner syndrome gene homologue

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

cellular response to DNA damage stimulus

regulation of growth rate

ISO

1 reference

9 May 2019

Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

multicellular organism aging

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09053&geneProductId=UniProtKB:O09053

24 April 2018

Essential role of limiting telomeres in the pathogenesis of Werner syndrome

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09053&geneProductId=UniProtKB:O09053

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09053&geneProductId=UniProtKB:O09053

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

14 February 2019

Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

14 February 2019

Essential role of limiting telomeres in the pathogenesis of Werner syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

14 February 2019

Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

nucleobase-containing compound metabolic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

nucleic acid phosphodiester bond hydrolysis

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

3 references

double-strand break repair via homologous recombination

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

double-strand break repair

cellular response to gamma radiation

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

9 May 2019

A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

9 May 2019

BLM helicase facilitates telomere replication during leading strand synthesis of telomeres

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

9 May 2019

BLM helicase facilitates telomere replication during leading strand synthesis of telomeres

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

G-quadruplex DNA unwinding

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09053&geneProductId=UniProtKB:O09053

24 April 2018

BLM helicase facilitates telomere replication during leading strand synthesis of telomeres

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09053&geneProductId=UniProtKB:O09053

24 April 2018

BLM helicase facilitates telomere replication during leading strand synthesis of telomeres

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09053&geneProductId=UniProtKB:O09053

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09053&geneProductId=UniProtKB:O09053

DNA synthesis involved in DNA repair

3 references

response to oxidative stress

3 references

determination of adult lifespan

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

cellular response to starvation

3 references

14 February 2019

Diverged nuclear localization of Werner helicase in human and mouse cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

3 references

multicellular organism aging

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

9 May 2019

Essential role of limiting telomeres in the pathogenesis of Werner syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

replication fork processing

3 references

regulation of apoptotic process

3 references

G-quadruplex DNA unwinding

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

9 May 2019

BLM helicase facilitates telomere replication during leading strand synthesis of telomeres

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

9 May 2019

BLM helicase facilitates telomere replication during leading strand synthesis of telomeres

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

positive regulation of hydrolase activity

3 references

telomeric D-loop disassembly

3 references

cellular response to gamma radiation

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

positive regulation of strand invasion

3 references

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

9 May 2019

Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

9 May 2019

Essential role of limiting telomeres in the pathogenesis of Werner syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

9 May 2019

Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

DNA unwinding involved in DNA replication

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09053

1 reference

Helicase superfamily 1/2, ATP-binding domain

1 reference

DEAD/DEAH box helicase domain

1 reference

Helicase Helix-turn-helix domain

1 reference

ATP-dependent DNA helicase RecQ, zinc-binding domain

1 reference

3'-5' exonuclease domain

1 reference

HRDC domain

1 reference

Helicase, C-terminal

1 reference